Results 31 to 40 of about 89,334 (262)
Microfluidic whole blood testing of platelet response to pharmacological agents
Platelets, 2017 Platelets present a number of intracellular and transmembrane targets subject to pharmacological modulation, either for cardiovascular disease reduction or as an unintended drug response.
Ruizhi Li +2 more
doaj +1 more source
Nucleotide-, chemotactic peptide- and phorbol ester-induced exocytosis in HL-60 leukemic cells [PDF]
, 1990 Undifferentiated and differentiated HL-60 leukemic cells possess nucleotide receptors which functionally couple to phospholipase C via pertussis toxin-sensitive guanine nucleotide-binding proteins (G-proteins).
Seifert, Roland +1 more
core +1 more source
Anti-platelet therapy: ADP receptor antagonists. [PDF]
, 2011 The P2Y(12) receptor on platelets with which ADP interacts has an important role in promoting platelet function and thereby platelet involvement in both haemostasis and thrombosis.
Heptinstall, S, Wijeyeratne, YD
core +2 more sources
Molecules, 2014 Nonsteroidal anti-inflammatory drugs (NSAIDs) 1–5 containing an N-acyl hydrazone subunit were prepared and their antiplatelet and antithrombotic activities assessed in vitro and in vivo.
Rafael Consolin Chelucci +6 more
doaj +1 more source
Assessment of the functional activity of platelets in chronic kidney disease stage 5D
Alʹmanah Kliničeskoj Mediciny, 2018 Rationale: Thromboembolic complications in patients on hemodialysis have a significant impact on the duration and quality of life. Aim: To study the functional status of platelets in chronic kidney disease stage 5D (CKD-5D).
K. N. Zelenin +2 more
doaj +1 more source
Східноукраїнський медичний журнал, 2021 The analysis of platelet aggregation in pregnant women with thrombophilia and burdened obstetric history was performed. It has been determined that the development of adverse effects of pregnancy is significantly influenced by conditions such as ...
Olha I. Zalyubovska +1 more
doaj +1 more source
The role of ectonucleotidases CD39 and CD73 and adenosine signalling in solid organ transplantation
Frontiers in Immunology, 2014 Extracellular adenosine is a potent immunomodulatory molecule that accumulates in states of inflammation. Nucleotides such as adenosine triphosphate (ATP) and adenosine diphosphate (ADP) are release from injured and necrotic cells and hydrolysed to ...
Veena eRoberts +2 more
doaj +1 more source
Adenosine diphosphate inhibits the serotonin transporter
Biochimica et Biophysica Acta (BBA) - Biomembranes, 1996 Adenosine 5'-diphosphate (ADP) caused rapid and significant reductions in the rates of [3H]serotonin uptake observed for human platelets, human platelet vesicles, and rat brain synaptic vesicles. Estimated Vmax values in platelets (N = 15). platelet vesicles (N = 3), and synaptic vesicles (N = 3) exposed to 100 microM ADP were 42.3 +/- 11.4%, 78.8 ...
William C. Horne +3 more
openaire +3 more sources
ADMINISTRATION OF FRUCTOSE 1,6-DIPHOSPHATE DURING EARLY REPERFUSION SIGNIFICANTLY IMPROVES RECOVERY OF CONTRACTILE FUNCTION IN THE POSTISCHEMIC HEART [PDF]
, 1998 Objectives: Fructose-1,6-diphosphate is a glycolytic intermediate that has been shown experimentally to cross the cell membrane and lead to increased glycolytic flux.
Cao-Danh, Hung +7 more
core +1 more source
Journal of Biological Chemistry, 1967 Abstract Pretreatment of adenosine diphosphate-G-actin solutions with apyrase results in a marked decrease in their rate of polymerization at 0° induced by KCl, creatine phosphate, and creatine kinase. In contrast, apyrase has no effect on the rate of polymerization of ATP-G-actin.
B. Nagy, J.J. West, John Gergely
openaire +3 more sources