Results 201 to 210 of about 296,423 (346)

Mitochondrial stress in advanced fibrosis and cirrhosis associated with chronic hepatitis B, chronic hepatitis C, or nonalcoholic steatohepatitis

Hepatology, EarlyView., 2022
Adaptive mitochondrial mechanisms allow mitochondrial resilience and prevent the worsening of fibrosis, while deregulation of these mechanisms promotes the progression from no/minimal‐mild (F0‐F2) fibrosis to advanced fibrosis and cirrhosis (F3‐F4). Abstract Background and Aims Hepatitis B virus (HBV) infection causes oxidative stress (OS) and alters ...
Dimitri Loureiro, Issam Tout, Stéphanie Narguet, Cheikh Mohamed Bed, Morgane Roinard, Ahmad Sleiman, Nathalie Boyer, Nathalie Pons‐Kerjean, Corinne Castelnau, Nathalie Giuly, Dorothy Tonui, Vassili Soumelis, Jamel El Benna, Patrick Soussan, Richard Moreau, Valérie Paradis, Abdellah Mansouri, Tarik Asselah   +17 more
wiley   +1 more source

A monomer-dimer switch modulates the activity of plant adenosine kinase. [PDF]

J Exp Bot
Kopečný DJ, Vigouroux A, Bělíček J, Kopečná M, Končitíková R, Friedecká J, Mik V, Supíková K, Humplík JF, Le Berre M, Plancqueel S, Strnad M, von Schwartzenberg K, Novák O, Moréra S, Kopečný D.   +15 more
europepmc   +1 more source

Adenosine kinase is critical for neointima formation after vascular injury by inducing aberrant DNA hypermethylation. [PDF]

Cardiovasc Res, 2021
Wang Y, Xu Y, Yan S, Cao K, Zeng X, Zhou Y, Liu Z, Yang Q, Pan Y, Wang X, Boison D, Su Y, Jiang X, Patel VS, Fulton D, Weintraub NL, Huo Y.   +16 more
europepmc   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Adenosine Kinase: An Epigenetic Modulator and Drug Target. [PDF]

J Inherit Metab Dis
Peter-Okaka U, Boison D.
europepmc   +1 more source

Protein kinase C inhibits cyclic adenosine monophosphate generation by histamine and truncated glucagon like peptide 1 in the human gastric cancer cell line HGT-1. [PDF]

, 1993
Paul McKenna, Julie M. Williams, Christian Gespach, Peter J. Hanson   +3 more
openalex   +1 more source

Remote Activation of Spinal TRPV1 by Magnetic Nanocubes Confers Cardioprotection Against Myocardial Ischemia‐Reperfusion Injury

Advanced Science, EarlyView.
Fe‐based magnetic nanocubes conjugated with TRPV1 antibodies (FeNCs‐TRPV1) are developed for the specific targeting of TRPV1 channels. Intraspinally injected FeNCs‐TRPV1 induces TRPV1 desensitization in rats exposed to repetitive and transient ACMF.
Xueying Cheng, Shuangyu Liu, Yu Zhang, Kang Peng, Muge Qile, Chao Wu, Mengyun Dou, Liu Liu, Na Yang, Rui Liu, Guiyang Zhang, Liangping Ni, Gaolin Liang, Fang Yang, Ye Zhang, Shufang He   +15 more
wiley   +1 more source

A novel molecular switch in plant growth: how adenosine kinase activity modulates plant development and growth pathways. [PDF]

J Exp Bot
Watson KM.
europepmc   +1 more source

A2B adenosine receptor-triggered intracellular calcium mobilization: Cell type-dependent involvement of Gi, Gq, Gs proteins and protein kinase C [PDF]

Zhan-Guo Gao, Ray R. Gao, Christina Meyer, Kenneth A. Jacobson   +3 more
openalex   +1 more source

Recent Developments in the Discovery of Novel Adenosine Kinase Inhibitors: Mechanism of Action and Therapeutic Potential [PDF]

, 2001
Steve McGaraughty, Marlon Cowart, Michael F. Jarvis   +2 more
openalex   +1 more source