Results 221 to 230 of about 165,863 (254)
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Regulation of adenosine kinase by adenosine analogs.
Molecular Pharmacology, 1988The regulation of adenosine phosphorylation by adenosine analogs was studied using highly purified human placental adenosine kinase [ATP: adenosine 5'-phosphotransferase (EC 2.7.1.20)]. Our observations lead us to classify the analogs into three groups as follows: type I, 5'-N-ethylcarboxamidoadenosine and 5'-methylthioadenosine; type II, N6 ...
B B, Lin, M C, Hurley, I H, Fox
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On the Modification of Adenosine Kinase by Thiols
Hoppe-Seyler´s Zeitschrift für physiologische Chemie, 1978The catalytic activity of adenosine kinase (EC 2.7.1.20) from yeast is very labile. Even incubation with thiols provokes a loss of two thirds of its enzymatic activity. Concomitantly, two SH-groups appear on the enzyme in addition to the single SH-group already present in the untreated enzyme, the latter being absolutely essential for activity ...
T J, Neudecker, G R, Hartmann
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Nonnucleoside Inhibitors of Adenosine Kinase
Current Pharmaceutical Design, 2004Adenosine (ADO) is an endogenous inhibitory neuromodulator that increases nociceptive thresholds in response to tissue trauma and inflammation. Adenosine kinase (AK) is a key intracellular enzyme regulating intra- and extracellular concentrations of ADO.
Arthur, Gomtsyan, Chih-Hung, Lee
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Adenosine Metabolism, Adenosine Kinase, and Evolution
2012The enzyme adenosine kinase (AdK, ADK, or AK) plays an important role in regulating the intracellular as well as extracellular concentrations of adenosine and hence its diverse physiological actions. In view of the enormous pharmacological potential of adenosine, there has been much interest in studying adenosine kinase over the past few decades.
Jaoek Park, Radhey S. Gupta
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Current Pharmaceutical Design, 1998
Abstract: Adenosine (ADO) is an endogenous modulator of intercellular signaling that provides homeostatic reductions in cell excitability during tissue stress and trauma. The inhibitory actions of ADO are mediated by interactions with specific cell-surface G protein coupled receptors regulating membrane cation flux, polarization, and the release of ...
Elizabeth A. Kowaluk +2 more
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Abstract: Adenosine (ADO) is an endogenous modulator of intercellular signaling that provides homeostatic reductions in cell excitability during tissue stress and trauma. The inhibitory actions of ADO are mediated by interactions with specific cell-surface G protein coupled receptors regulating membrane cation flux, polarization, and the release of ...
Elizabeth A. Kowaluk +2 more
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Erythrocyte adenosine kinase activity in gout
Clinica Chimica Acta, 1976Erythrocyte adenosine kinase (AK) (EC 2.7.1.20) and guanosine monophosphate (GMP) reductase (EC 1.6.6.8) were measured in healthy male controls and primary gout subjects. Adenosine kinase activity in 19 controls and 26 gouty subjects was 0.717 +/- 0.176 and 0.615 +/- 0.128 nmol/mg protein/h, respectively. The difference was statistically significant (p
T, Nishizawa, Y, Nishida, I, Akaoka
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Adenosine kinase from Cryptosporidium parvum
Molecular and Biochemical Parasitology, 2006Analysis of the Cryptosporidium parvum genome demonstrates that the parasite cannot synthesize purines de novo and reveals that the sole route for purine salvage by the parasite is via adenosine kinase (CpAK). In order to initiate a biochemical characterization of CpAK and ultimately validate this apparently essential enzyme as a therapeutic target ...
Jon, Galazka +2 more
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Adenosine kinase from Trypanosomacruzi
Biochemical and Biophysical Research Communications, 1982Abstract Adenosine kinase was demonstrated in the soluble fraction of Trypanosoma cruzi . Magnesium is required for activity. ATP and GTP are efficient phosphate donors while p - nitrophenylphosphate is without activity. The pH optimum is high (8.0), it is heat labile and is stabile to freezing (−20° or −80°). It is substrate inhibited,
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Isolation and Immunological Properties of Adenosine Kinase
Preparative Biochemistry, 1989Bovine liver adenosine kinase is a 43 kDa protein that catalyzes the transfer of phosphate from GTP or ATP to adenosine. Its immunological properties were compared to other GTP-binding proteins of approximately 40 kDa, in particular those involved in signal transduction, such as Gs and Gi, the stimulatory and inhibitory regulatory proteins of adenylyl ...
M, Noda +7 more
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Journal of Molecular and Cellular Cardiology, 1999
Adenosine levels present in the interstitial fluid and coronary effluent of the aged heart exceed those of the young adult heart. The present study investigated mechanisms in the Fischer 344 rat heart which may be responsible for the observed differences. (1) Total production of adenosine was determined in isolated perfused hearts by measuring coronary
Lorbar, Mojca +4 more
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Adenosine levels present in the interstitial fluid and coronary effluent of the aged heart exceed those of the young adult heart. The present study investigated mechanisms in the Fischer 344 rat heart which may be responsible for the observed differences. (1) Total production of adenosine was determined in isolated perfused hearts by measuring coronary
Lorbar, Mojca +4 more
openaire +3 more sources