Results 101 to 110 of about 227,189 (359)

Sonoepigenetic Modification Mechanoprimes Early Osteogenic Commitment in Mesenchymal Stem Cells

Advanced Science, EarlyView.
Brief 10 min bursts of high frequency (10 MHz) vibrational mechanostimulation to stem cells are shown to activate their epigenetic machinery to condition their differentiation down an osteogenic lineage within just 3 days, which is much earlier than that with other forms of mechanostimuli, and without requiring any biochemical additives. Abstract Cells
Lizebona A. Ambattu, Blanca del Rosal, Carmelo Ferrai, Leslie Y. Yeo   +3 more
wiley   +1 more source

Dynamical strategies for obstacle avoidance during Dictyostelium discoideum aggregation: a Multi-agent system model [PDF]

, 2019
Chemotaxis, the movement of an organism in response to chemical stimuli, is a typical feature of many microbiological systems. In particular, the social amoeba \textit{Disctyostelium discoideum} is widely used as a model organism, but it is not still ...
Maggiora, Marco, Proverbio, Daniele
core   +1 more source

Tensin links energy metabolism to extracellular matrix assembly. [PDF]

, 2017
The regulation of integrin function is key to fundamental cellular processes, including cell migration and extracellular matrix (ECM) assembly. In this issue, Georgiadou et al. (2017. J. Cell Biol.
Calderwood, Emmanuel Dornier, Hardie, Hardie, Horton, Jim C. Norman, McCleverty, Muranen, Pankov, Rainero, Rantala, Rowe, Schiller, Singh, Van Obberghen-Schilling, Yamada   +15 more
core   +3 more sources

Inhaling Eugenol Inhibits NAFLD by Activating the Hepatic Ectopic Olfactory Receptor Olfr544 and Modulating the Gut Microbiota

Advanced Science, EarlyView.
Inhalable eugenol (EUG) from clove oil attenuates NAFLD by activating hepatic olfactory receptor Olfr544, triggering cAMP/PKA/CREB signaling to enhance lipolysis/oxidation. EUG concurrently restores gut microbiota, enriching probiotics (L. reuteri XR23/L. johnsonii XR25) and metabolites (IPA/5‐HIAA) that suppress lipogenesis.
Xiao‐Ran Wang, Zhan‐Zhan Li, Shu‐Ding Sun, Ya‐Gang Song, Jin‐Xin Miao, Xiang‐Xiang Wu, Yong‐Li Han, Xiao‐Lei Zhang, Wen‐Jing Chen, Qing‐Hua Wang, Yu Zhang, Yiping Fu, Yu‐ting Liu, Lin‐yan Lang, Wen‐Xia Zhao, Ming‐San Miao   +15 more
wiley   +1 more source

Virulence‐Selective Trap–Capture–Kill Antibacterial Nanostructures With Immune–Metabolic Regulation for Treating Implant‐Associated Infections

Advanced Science, EarlyView.
A virulence‐selective antibacterial system based on fascaplysin derivative 14‐modified TiO2 nanostructure (F‐14‐TNA) is developed for treating implant‐associated infections. F‐14‐TNA selectively traps hyperpathogenic bacteria via chemotaxis, captures them electrostatically, and kills them via reactive oxygen species‐mediated pathways.
Xiaodong Hu, Jiaqi Zhong, Yujiong Chen, Botao Liu, Tianyu Du, Weilai Zhu, Minzhe Zheng, Hongze Liang, Jiahua Ni, Zhaoxiang Peng   +9 more
wiley   +1 more source

AMPc: una molécula clave en los eventos de regulación inmune y en el control de la replicación del VIH cAMP: A keymolecule in events of immune regulation and in the control of HIV replication

Infectio, 2012
El monofosfato de adenosina cíclico (AMPc) induce la activación de la proteína cinasa A, la cual regula negativamente la activación, la proliferación celular y la producción de IL-2, en células T.
César Mauricio Rueda, Paula Andrea Velilla, Mauricio Rojas, María Teresa Rugeles   +3 more
doaj  

The effects of portacaval shunt upon hepatic cholesterol synthesis and cyclic AMP in dogs and baboons [PDF]

, 1980
Hepatic cholesterol synthesis, hepatic cyclic AMP, and portal and peripheral insulin and glucagon levels were investigated in nine dogs and three baboons after complete portacaval shunt.
Benichou, J, Francavilla, A, Jones, AF, Starzl, TE   +3 more
core  

CBS domains form energy-sensing modules whose binding of adenosine ligands is disrupted by disease mutations [PDF]

, 2004
CBS domains are defined as sequence motifs that occur in several different proteins in all kingdoms of life. Although thought to be regulatory, their exact functions have been unknown.
Anis, Miliea, Green, Kevin A., Hardie, D. Grahame, Hawley, Simon A., Norman, David G., Scott, John W., Scullion, Gillian A., Stewart, Greg   +7 more
core   +6 more sources

Transcriptomics Guided Engineering of Exosome‐Encapsulated Bifunctional Nanosheets Targeting the Immune‐PI3K/Akt Axis for Osteoporosis Therapy

Advanced Science, EarlyView.
A multifunctional nanosheet–exosome hybrid system incorporating f‐CA(OH) nanosheets enriched with abundant surface vacancies are developed. These nanosheets fuse with natural exosomes, endowing them with nanozyme‐like catalytic capabilities while retaining their inherent biological functions.
Rongze Tang, Guanhong Liu, Congcong Wang, Minghao Chao, Guangyu Ma, Pengjin Wei, Siling Du, Junjie Li, Yufan Liu, Chaonan Jing, Guoquan Wu, Ming Guan, Hongliang Chen, Fenglei Gao   +13 more
wiley   +1 more source

The role of cyclic nucleotide on fetal and neonantal erythropoiesis [PDF]

, 1974
For the purpose to reveal the changes in stimulatory effect of dibutyryl-cyclic- AMP on erythropoiesis during ontogenetic development, the author studied syntheses of DNA, RNA and protein of erythroid cells in fetal liver, neonatal and adult bone marrows
Tada, Hiroshi
core   +1 more source