Results 101 to 110 of about 95,796 (312)

ADCY5‐Mosaic Variants: A Diagnosis Not to Be Missed

open access: yesMovement Disorders Clinical Practice, EarlyView.
Abstract Background An increasing number of ADCY5‐mosaic patients, seemingly with a milder phenotype, are being identified. However, an in‐depth assessment of their clinical characteristics is lacking. Cases We collected and analyzed data from 12 consecutive ADCY5‐mosaic patients diagnosed at our center and 7 cases from the literature; 63% of the ...
Alice Innocenti   +20 more
wiley   +1 more source

Early‐Onset Movement Disorder Syndrome Caused by Biallelic Variants in PDE1B Encoding Phosphodiesterase 1B

open access: yesMovement Disorders, EarlyView.
Abstract Background Breakdown of cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP) in basal ganglia cells through hydrolysis of diesteric bonds, primarily by PDE10A and PDE1B, is essential for normal human movement. While biallelic loss‐of‐function variants in PDE10A are known to cause hyperkinetic movement disorders, the ...
Tomer Poleg   +21 more
wiley   +1 more source

Molecular Tools to Study and Control Dopaminergic Neurotransmission With Light

open access: yesMedicinal Research Reviews, EarlyView.
ABSTRACT Dopaminergic neurotransmission is involved in several important brain functions, such as motor control, learning, reward‐motivated behavior, and emotions. Dysfunctions of dopaminergic system may lead to the development of various neurological and psychiatric disorders, like Parkinson's disease, schizophrenia, depression, and addictions ...
Galyna Maleeva   +5 more
wiley   +1 more source

Natural Peptides Versus Semaglutide: A Safer Approach to Obesity Management

open access: yesMedicine Advances, EarlyView.
This paper highlights that while semaglutide is effective for weight loss, it is associated with significant side effects, high cost, and muscle loss. In contrast, natural peptides such as BRP, BPC‐157, and MOTS‐c demonstrate promising anti‐obesity effects with fewer adverse outcomes, improved safety profiles, and potential affordability making them ...
Muhammad Affan Abid   +2 more
wiley   +1 more source

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