Results 121 to 130 of about 145,554 (263)

Structural Heterogeneity of Proteoform-Ligand Complexes in Adenosine Monophosphate-Activated Protein Kinase Uncovered by Integrated Top-Down Mass Spectrometry. [PDF]

J Am Chem Soc
Chan HJ, Krichel B, Bandura LJ, Chapman EA, Rogers HT, Fischer MS, Roberts DS, Gao Z, Wang MD, Wu J, Uetrecht C, Jin S, Ge Y.   +12 more
europepmc   +1 more source

Cyclic adenosine monophosphate-elevating agents inhibit amyloid-beta internalization and neurotoxicity: their action in Alzheimer's disease prevention. [PDF]

Neural Regen Res, 2023
Gopalakrishna R, Oh A, Bhat NR, Mack WJ.
europepmc   +1 more source

Impact of Metformin and Diabetes on Tumor Response to Total Neoadjuvant Therapy in Advanced Rectal Cancer: A Multicenter Retrospective Cohort Study

Asia-Pacific Journal of Clinical Oncology, EarlyView.
In advanced rectal cancer patients receiving total neoadjuvant therapy (TNT), overall tumor response did not differ by diabetes status or metformin use. However, among diabetic patients, metformin use was associated with higher overall complete response rates. These findings suggest a potential benefit of metformin in enhancing TNT response in diabetic
Sergei Bedrikovetski, Mahima Raju, Tracy Fitzsimmons, Ishraq Murshed, Timothy J. Price, Michael Penniment, Sudarsha Selva‐Nayagam, Tarik Sammour   +7 more
wiley   +1 more source

TrkA of <i>Streptococcus mitis</i> CCUG31611 binds cyclic di-adenosine monophosphate and is required for growth in low potassium conditions. [PDF]

Microbiology (Reading)
Vevik K, Sribasgaran B, Cai K, Naemi AO, Pedersen Kaspersen H, Uhlig S, Økstad OA, Simm R.   +7 more
europepmc   +1 more source

Update on Non‐Biological and RNA‐Based Therapeutics in Chronic Inflammatory Diseases: Precision Medicine Through Small Molecules: An EAACI Position Paper

Allergy, EarlyView.
ABSTRACT In the last decades, critical advancements in research technology and knowledge on disease mechanisms steered therapeutic approaches for chronic inflammatory diseases towards unprecedented target specificity. For allergic and chronic lung diseases, biologic drugs pioneered this goal, acquiring on the way—through the clinical use of monoclonal ...
F. Roth‐Walter, I. M. Adcock, C. Benito‐Villalvilla, R. Bianchini, L. Bjermer, G. Caramori, L. Cari, K. F. Chung, Z. Diamant, I. Eguiluz‐Gracia, E. F. Knol, M. Jesenak, F. Levi‐Schaffer, G. Nocentini, L. O'Mahony, O. Palomares, F. Redegeld, M. Sokolowska, B. Van Esch, M. Zurlo, C. Stellato   +20 more
wiley   +1 more source

Adenosine Monophosphate-Activated Protein Kinase Activation and Mammalian Target of Rapamycin Complex 1 Inhibition: A Mechanistic Rationale for Anti-Aging Therapy in Type 2 Diabetes. [PDF]

J Clin Med Res
Yanai H, Adachi H, Hakoshima M, Katsuyama H.   +3 more
europepmc   +1 more source

Downregulation of cyclic adenosine monophosphate levels in leukocytes of hibernating captive black bears is similar to reported cyclic adenosine monophosphate findings in major depressive disorder. [PDF]

Front Psychiatry, 2023
Tsiouris JA, Flory M.
europepmc   +1 more source

Luteinizing hormone receptor knockout mouse: What has it taught us?

Andrology, EarlyView.
Abstract Luteinizing hormone (LH), along with its agonist choriongonadotropin (hCG) in humans, is the key hormone responsible for the tropic regulation of the gonadal function. LH and hCG act through their cognate receptor, the luteinizing hormone/choriongonadotropin receptor (LHCGR; more appropriately LHR in rodents lacking CG), located in the testis ...
Ilpo T. Huhtaniemi
wiley   +1 more source

Bacterial membrane vesicles of <i>Pseudomonas aeruginosa</i> activate adenosine monophosphate-activated protein kinase signaling through inhibition of mitochondrial complex III. [PDF]

PNAS Nexus
Müller J, Kretschmer M, Opitsch E, Holland S, Borrero-de Acuña JM, Jahn D, Neumann-Schaal M, Wegner A.   +7 more
europepmc   +1 more source

Dopamine and cyclic adenosine monophosphate-regulated phosphoprotein with an apparent Mr of 32000 promotes colorectal cancer growth. [PDF]

World J Gastrointest Oncol, 2023
He K, Xie CZ, Li Y, Chen ZZ, Xu SH, Huang SQ, Yang JG, Wei ZQ, Peng XD.   +8 more
europepmc   +1 more source