Results 151 to 160 of about 165,902 (383)
DNA sensor cGAS-mediated immune recognition
Protein & Cell, 2016 The host takes use of pattern recognition receptors (PRRs) to defend against pathogen invasion or cellular damage. Among microorganism-associated molecular patterns detected by host PRRs, nucleic acids derived from bacteria or viruses are tightly ...
Pengyan Xia +4 more
doaj +1 more source
Chemistry – A European Journal, EarlyView.We report a simple, efficient, and cost‐effective methodology for introducing amino‐modifiers into DNA and RNA using a commercially available solid support. By incorporating a base‐labile sulfonyl linker within the strand, we developed an amino‐containing tandem oligonucleotide synthesis (aTOS) methodology, which enables the introduction of multiple ...
Jagandeep S. Saraya +3 more
wiley +1 more source
Thoracic Cancer, Volume 13, Issue 23, Page 3322-3330, December 2022., 2022 Alterations in LKB1/AMPK and downstream pathway may modify the response of cancer cells to chemotherapy and clinical outcomes. This study showed that two genetic variants in LKB1/AMPK/mTOR pathway, the AKT1 rs2494750G〉C and TSC1 rs2809244C〉A, were associated with the clinical outcomes after paclitaxel‐cisplatin chemotherapy in patients with advanced ...
Sun Ha Choi +19 more
wiley +1 more source
Kinetic Analysis of Protein Assembly on the Basis of the Center Manifold around the Critical Point [PDF]
arXiv, 2015 Protein assembly plays an important role in the regulation of biological systems. The cytoskeleton assembly activity is provided by the binding cofactors GTP (guanidine triphosphate) or ATP(adenosine triphosphate) to monomeric protein, and is initiated by assembling the monomeric proteins.
arxiv
Clearing-factor lipase in adipose tissue. A possible role of adenosine 3′,5′-(cyclic)-monophosphate in the regulation of its activity [PDF]
, 1968 D. R. Wing, D. S. Robinson
openalex +1 more source
Clinical Pharmacology in Drug Development, EarlyView.Abstract This small phase 1C, open‐label, single ascending dose study evaluated the safety, tolerability, and pharmacokinetics (PKs) of DM199, a recombinant form of human tissue kallikrein‐1 (KLK1). A small sample size of both healthy subjects and hypertensive adults recently taking angiotensin‐converting enzyme inhibitors was studied. KLK1 has a known
Michael Giuffre +3 more
wiley +1 more source
Kinetic Analysis of the Antidiuretic Action of Vasopressin and Adenosine-3′,5′-Monophosphate * [PDF]
, 1964 Isidore S. Edelman +2 more
openalex +1 more source
Clinical Pharmacology in Drug Development, EarlyView.Abstract A combination of nucleotide hepatitis C virus (HCV) nonstructural protein (NS) 5B and 5A inhibitors is a preferred standard of care for treating chronic HCV. Bemnifosbuvir is a novel oral guanosine nucleotide prodrug with potent pan‐genotypic inhibitory activity against HCV NS5B.
Xiao‐Jian Zhou +7 more
wiley +1 more source
arXiv, 2017 Expressing the energy content of food as the heat energy released by its combustion is potentially misleading. Food is used to produce adenosine triphosphate (ATP). The free energy of conversion of ATP into adenosine diphosphate is used directly for processes such as muscular contraction, without the need for intermediate heat production. The number of
arxiv
Advances in Isotope Labeling for Solution Nucleic Acid Nuclear Magnetic Resonance Spectroscopy
ChemPlusChem, EarlyView.Recent advances in the field of nucleic acid nuclear magnetic resonance (NMR) are presented. Stable isotope labeling protocols and new approaches to segmentally label nucleic acid with NMR‐active residues are summarized. The novel methods will have a strong impact on the future of nucleic acid NMR and the characterization of structure and dynamics of ...
Stefan Hilber +3 more
wiley +1 more source