Results 211 to 220 of about 95,796 (312)

Linear free energy relationship between reduction potential and photoreduction rate: studies on Drosophila cryptochrome

open access: yesThe FEBS Journal, EarlyView.
A series of modified FAD cofactors have been used to modulate the photochemistry of FAD‐containing cryptochrome. When 7‐halogenated FADs were used, a significantly faster signaling‐state formation was observed, due to the more positive reduction potentials and higher triplet yields compared to the natural FAD cofactors; thus, this study shows that the ...
Moustafa Okasha   +8 more
wiley   +1 more source

Lipid regulation of adenylyl cyclase Rv1625c from Mycobacterium tuberculosis by its membrane‐domain receptor

open access: yesThe FEBS Journal, EarlyView.
The adenylyl cyclase (AC) Rv1625c from M. tuberculosis is a monomeric progenitor of the nine pseudoheterodimeric mammalian AC isoforms. The hexahelical membrane anchor of Rv1625c serves as an inhibitory receptor for fatty acids, particularly oleic acid. One ligand binds into each monomer of the active Rv1625c dimer.
Anita Charlotte Friderun Schultz   +3 more
wiley   +1 more source

Protein kinase A: a quirky prototype

open access: yesThe FEBS Journal, EarlyView.
Protein kinase A (PKA) has served as a prototype for establishing kinase fundamentals, including sequence, structure and catalytic mechanism. However, PKA is quirky in some respects. Its regulatory elements are expressed separately, including type I (RI) regulatory subunits that contain unusual disulphide‐linked dimerization and docking domains ...
Matthew G. Gold
wiley   +1 more source

Ras pathways help buffer biological timekeeping against metabolic perturbations

open access: yesThe FEBS Journal, EarlyView.
Circadian clocks must be buffered (compensated) against conditions that could affect their rate (period). This figure shows rhythmic peaks of spore formation driven by the clock of the fungus Neurospora: The period is the same under different nutritional conditions in the wild‐type but not in a RasGEF mutant that disrupts an intracellular signaling ...
Patricia Lakin‐Thomas
wiley   +1 more source

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