Results 211 to 220 of about 347,631 (311)

The return of metabolism: biochemistry and physiology of glycolysis

Biological Reviews, EarlyView.
ABSTRACT Glycolysis is a fundamental metabolic pathway central to the bioenergetics and physiology of virtually all living organisms. In this comprehensive review, we explore the intricate biochemical principles and evolutionary origins of glycolytic pathways, from the classical Embden–Meyerhof–Parnas (EMP) pathway in humans to various prokaryotic and ...
Nana‐Maria Grüning, Federica Agostini, Camila Caldana, Johannes Hartl, Matthias Heinemann, Markus A. Keller, Jan Lukas Krüsemann, Costanza Lamperti, Carole L. Linster, Steffen N. Lindner, Julia Muenzner, Jens Nielsen, Zoran Nikoloski, Bettina Siebers, Jacky L. Snoep, Hezi Tenenboim, Bas Teusink, Spencer J. Williams, Mirjam M. C. Wamelink, Markus Ralser   +19 more
wiley   +1 more source

A Hypothesis That Glucagon-like Peptide-1 Receptor Agonists Exert Immediate and Multifaceted Effects by Activating Adenosine Monophosphate-Activate Protein Kinase (AMPK). [PDF]

Life (Basel)
Schooling CM, Yang G, Soliman GA, Leung GM.   +3 more
europepmc   +1 more source

Development of novel adenosine monophosphate-activated protein kinase activators.

Journal of Medicinal Chemistry, 2010
J. Guh, Wei-Ling Chang, Jian Yang, Su-Lin Lee, Shuo Wei, Dasheng Wang, S. Kulp, Ching S. Chen   +7 more
semanticscholar   +1 more source

Targeting Genome Maintenance Defects of Cancers Using Chain‐Terminating Nucleoside Analogs

Cancer Science, EarlyView.
Nucleoside analogs interfere with DNA replication either by their chain‐terminating properties or by serving as DNA damage on the template. The genome maintenance pathways required to maintain cellular tolerance to each nucleoside analog vary depending on the drug.
Ryotaro Kawasumi, Rubaiat E. Tabassum, Kouji Hirota   +2 more
wiley   +1 more source

Role of cyclic guanosine monophosphate-adenosine monophosphate synthase-stimulator of interferon genes pathway in diabetes and its complications. [PDF]

World J Diabetes
Fan MW, Tian JL, Chen T, Zhang C, Liu XR, Zhao ZJ, Zhang SH, Chen Y.   +7 more
europepmc   +1 more source

Evidence for an essential arginine recognition site on adenosine 3′:5′-cyclic monophosphate-dependent protein kinase of rabbit skeletal muscle

, 1978
Masafumi Matsuo, C.H. Huang, Laura C. Huang   +2 more
openalex   +2 more sources

OSA Initiates Histone Lactylation That Drives PDE4B/FUS/AGT Axis to Pulmonary Hypertension

Cell Proliferation, EarlyView.
This study illustrates how chronic intermittent hypoxia (CIH) in obstructive sleep apnea (OSA) leads to hypertension via increased oxidative stress and mitochondrial dysfunction in pulmonary artery smooth muscle cells (PASMCs), causing glycolytic dysregulation. Lactate accumulation enhances histone lactylation, upregulating phosphodiesterase 4B (PDE4B),
Li Yang, Qing Ni, Yan He, Shijie Liu, Lulu Gan, Anni Dai, Yang Hu, Qian Liu, Xueling Yang, Jiqian Li, Yi Tao, Yunyu Li, Mingyue Xu   +12 more
wiley   +1 more source

Dysregulated biosynthesis and hydrolysis of cyclic-di-adenosine monophosphate impedes sporulation and butanol and acetone production in <i>Clostridium beijerinckii</i> NCIMB 8052. [PDF]

Front Bioeng Biotechnol
Awaga-Cromwell MM, Kumar S, Truong HM, Agyeman-Duah E, Okonkwo CC, Ujor VC.   +5 more
europepmc   +1 more source

Cyclic Adenosine 3′:5′-Monophosphate and Cyclic Guanosine 3′:5′-Monophosphate Phosphodiesterase Activities Are under Separate Genetic Control

, 1974
Tom R. Russell, Ira Pastan
openalex   +1 more source

Lactate Accelerates Early Angiogenesis and Bone Regeneration Through Macrophage M1 Polarisation

Cell Proliferation, EarlyView.
During the early stage of bone defect healing, lactate accumulates and contributes to increasing NOD1 expression by stabilising HIF1α that in turn triggers a calcium influx, which ultimately polarises macrophages towards the M1 phenotype and accelerates vascularisation of endothelial cells.
Lulu Liu, Danning Ma, Jia Song, Boon Chin Heng, Ying Huang, Xuehui Zhang, Mingming Xu, Yan Wei, Tai Wei, Jinqi Wei, Xuliang Deng   +10 more
wiley   +1 more source