Results 271 to 280 of about 227,189 (359)

Anti‐inflammatory effects of physical stimuli: The central role of networks in shaping the future of pharmacological research

British Journal of Pharmacology, EarlyView.
Addressing complexity in the study of life sciences through Systems Biology and Systems Medicine has been transformative, making Systems Pharmacology the next logical step. In this review, we focus on physical stimuli, whose potential in pharmacology has been neglected, despite demonstrated therapeutic properties.
Veronica Paparozzi, Reyhaneh Hooshmandabbasi, Alessandro Ravoni, Ying Ma, Luigi Manni, Timothy J. Koh, Caroline Maake, Tiziana Guarnieri, Darong Lai, Vitalii Zablotskii, Christine Nardini   +10 more
wiley   +1 more source

The activation of adenosine monophosphate-activated protein kinase inhibits the migration of tongue squamous cell carcinoma cells by targeting Claudin-1 via epithelial-mesenchymal transition. [PDF]

Animal Model Exp Med
Zhou XY, Liu QM, Li Z, Liu XY, Zhao QW, Wang Y, Wu FH, Zhao G, Sun R, Guo XH.   +9 more
europepmc   +1 more source

Effects of adenosine 3':5'-monophosphate and related agents on ribonucleic acid synthesis and morphological differentiation in mouse neuroblastoma cells in culture.

, 1975
RI Glazer, FH Schneider
openalex   +1 more source

Compartmentalisation in cAMP signalling: A phase separation perspective

British Journal of Pharmacology, EarlyView.
Cells rely on precise spatiotemporal control of signalling pathways to ensure functional specificity. The compartmentalisation of cyclic AMP (cAMP) and protein kinase A (PKA) signalling enables distinct cellular responses within a crowded cytoplasmic space.
Milda Folkmanaite, Manuela Zaccolo
wiley   +1 more source

Non‐canonical PKG1 regulation in cardiovascular health and disease

British Journal of Pharmacology, EarlyView.
It is well established that the cyclic GMP‐dependent protein kinase I (PKG1) is canonically activated by cyclic guanosine monophosphate (cGMP), enabling its regulation of vascular tone, cardiac function and smooth muscle homeostasis. However, diverse non‐canonical stimuli of PKG1 have also been identified.
Jie Su, Joseph Robert Burgoyne
wiley   +1 more source

Hypothermia increases adenosine monophosphate and xanthosine monophosphate levels in the mouse hippocampus, preventing their reduction by global cerebral ischemia. [PDF]

Sci Rep
Doshi M, Natori Y, Ishii A, Saigusa D, Watanabe S, Hosoyamada M, Hirashima-Akae Y.   +6 more
europepmc   +1 more source

Adenosine 3‘ :5‘ -monophosphate-dependnet phosphorylations of renal subcellular fractions. Differences between cortical and medullary membrane preparations.

, 1978
Francis C. Szoka, Murray J. Ettinger
openalex   +1 more source

Exploiting PP2A dependent and independent effects of forskolin for therapeutic targeting of KMT2A (MLL)‐rearranged acute leukaemia

British Journal of Pharmacology, EarlyView.
Background and Purpose Activation of Protein Phosphatase 2A (PP2A), via genetic and pharmacologic modulation of SET, has recently being identified as a promising strategy to therapeutically target acute myeloid leukaemia (AML) carrying KMT2A (MLL) chromosomal translocations (KMT2A‐r AML).
Yoana Arroyo‐Berdugo, Antonella Di Mambro, Volker Behrends, Michelle A. Sahai, Luca Cozzuto, Immacolata Zollo, Julia Ponomarenko, Owen Williams, John Gribben, Yolanda Calle, Bela Patel, Maria Teresa Esposito   +11 more
wiley   +1 more source

Two missense STK11 gene variations impaired LKB1/adenosine monophosphate-activated protein kinase signaling in Peutz-Jeghers syndrome. [PDF]

World J Gastrointest Oncol
Liu J, Zeng SC, Wang A, Cheng HY, Zhang QJ, Lu GX.   +5 more
europepmc   +1 more source

Studies with the Cyclic Adenosine Monophosphate Receptor and Stimulation of in Vitro Transcription of the Gal Operon

, 1974
Wayne B. Anderson, Max E. Gottesman, Ira Pastan   +2 more
openalex   +1 more source