Results 61 to 70 of about 293,395 (315)

CAQ Corner: Basic concepts of transplant immunology

, 2022
Liver Transplantation, EarlyView.
Amanda Cheung, Josh Levitsky
wiley   +1 more source

The inhibition of skeletal-muscle fructose 1,6-diphosphatase by adenosine monophosphate [PDF]

, 1967
LH Opie, E. A. Newsholme
openalex   +1 more source

Deciphering the skeletal interoceptive circuitry to control bone homeostasis

BMEMat, EarlyView.
This review introduces the skeletal interoceptive circuitry, covering the ascending signals from bone tissues to the brain (sensors), the central neural circuits that integrate this information and dispatch commands (CPU), and the descending pathways that regulate bone homeostasis (effectors).
Yefeng Wu, Jiusi Guo, Zhen Chen, Fengwei Zhang, Billy Kwok Chong Chow, Zhuofan Chen, Kelvin Wai‐Kwok Yeung, Wei Qiao   +7 more
wiley   +1 more source

Ubiquitination in cancer: mechanisms and therapeutic opportunities

Cancer Communications, EarlyView.
Abstract Ubiquitination, a key post‐translational modification, plays an essential role in tumor biology by regulating fundamental cellular processes, such as metabolism and cell death. Additionally, it interacts with other post‐translational modifications, which are closely linked to tumorigenesis, tumor progression, the tumor microenvironment, and ...
Susi Zhu, Xu Zhang, Waner Liu, Zhe Zhou, Siyu Xiong, Jie Li, Xiang Chen, Cong Peng   +7 more
wiley   +1 more source

Quantification of Small Molecule Partitioning in a Biomolecular Condensate with 2D Nuclear Magnetic Resonance Spectroscopy

ChemBioChem, EarlyView.
Several intrinsically disordered proteins have been shown to undergo phase separation and it is highly relevant to know how small molecule metabolites distribute between these phases. It is shown here that the partitioning can be robustly obtained from 2D time‐zero heteronuclear single quantum coherence nuclear magnetic resonance spectra recorded on ...
Julie Maibøll Buhl, Sujata Mahapatra, Magnus Kjærgaard, Frans A. A. Mulder   +3 more
wiley   +1 more source

Photocaged Dinucleoside Tetraphosphates for Light‐Mediated Activation of 5′ Cap Interactions and Translation In Vitro

ChemistryEurope, EarlyView.
Photocaged dinucleoside tetraphosphates can be incorporated into mRNA by T7 RNA polymerase. Subsequent irradiation with light activates 5′ cap interactions and translation. These 5′ cap analogs are useful tools to probe the functions of naturally occurring dinucleoside tetraphosphates and their role in bacteria and mammalian cells.
Cedrik Kühling, Wiebke Teich, Bayram Terzi, Helena Schepers, Sabine Hüwel, Andrea Rentmeister   +5 more
wiley   +1 more source

Steric and Geometric Tuning of π‐Conjugated Antennae in Europium(III) Complexes for Selective ADP Recognition

Chemistry – A European Journal, EarlyView.
We present four new macrocyclic Eu(III) complexes and demonstrate how ligand structure and positional tuning of π‐conjugated antennae modulate steric demand and anion binding site geometry. This enables size and shape complementarity for selective ADP recognition in water over competing phosphoanions.
Samantha E. Bodman, Stephen J. Butler
wiley   +1 more source

Discovery and Preclinical Characterization of 6-Chloro-5-[4-(1-hydroxycyclobutyl)phenyl]-1H-indole-3-carboxylic Acid (PF-06409577), a Direct Activator of Adenosine Monophosphate-activated Protein Kinase (AMPK), for the Potential Treatment of Diabetic Nephropathy.

Journal of Medicinal Chemistry, 2016
K. O. Cameron, D. Kung, A. Kalgutkar, R. Kurumbail, Russell Miller, Christopher T. Salatto, J. Ward, J. Withka, S. Bhattacharya, M. Boehm, Kris A. Borzilleri, Janice A. Brown, M. Calabrese, N. Caspers, E. Cokorinos, Edward L. Conn, M. Dowling, David J. Edmonds, H. Eng, D. Fernando, Richard K. Frisbie, D. Hepworth, J. Landro, Yuxia Mao, F. Rajamohan, A. Reyes, Colin R. Rose, Tim F. Ryder, A. Shavnya, Aaron C. Smith, M. Tu, A. Wolford, Jun Xiao   +32 more
semanticscholar   +1 more source

C1′‐Branched Acyclic Nucleoside Phosphonates as Inhibitors of Plasmodium Falciparum 6‐Oxopurine Phosphoribosyltransferase

ChemMedChem, EarlyView.
Novel C1'‐branched acyclic nucleoside phosphonates were synthesized. The compounds are inhibitors of Plasmodium falciparum and human 6‐oxopurine phosphoribosyltransferases with Ki values as low as 0.4 µM and 0.7 µM, respectively. A phosphonodiamidate prodrug exhibited IC50 = 4.3 µM against a drug‐sensitive strain of P.
Jan Frydrych, Dianne T. Keough, Haojun Xia, Lenka Poštová Slavětínská, Martin Dračínský, Michal Česnek, Jye Travis, Marina Chavchich, Michael Edstein, Dana Hocková, Luke W. Guddat, Zlatko Janeba   +11 more
wiley   +1 more source

ADENOSINE TRIPHOSPHATE-ADENOSINE MONOPHOSPHATE TRANSPHOSPHORYLASE (MYOKINASE)

, 1957
Lafayette Noda, Stephen A. Kuby
openalex   +1 more source