Simulation and comparative analysis of binding modes of nucleoside and non-nucleoside agonists at the A2B adenosine receptor [PDF]
, 2013 Diego Dal Ben +4 more
openalex +1 more source
GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy
Advanced Science, EarlyView.Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu +11 more
wiley +1 more source
Unlocking the adenosine receptor mechanism of the tumour immune microenvironment. [PDF]
Front ImmunolHan Y, Dong C, Hu M, Wang X, Wang G.
europepmc +1 more source
Depletion of the RNA‐Editing Enzyme ADAR1 Invigorates the Antitumor Immunity of NK Cells
Advanced Science, EarlyView.ADAR1 is upregulated in NK cells from melanoma patients, impairing their function. Its loss enhances NK cell tumor infiltration and cytotoxicity in vitro and in vivo. Mechanistically, ADAR1 deficiency destabilizes CD38 mRNA to reduce its expression, thereby increasing NK cell mobility and killing, which nominates it as a therapeutic target for NK cell ...
Shuhan Chen +11 more
wiley +1 more source
Cantharidin attenuates the anti-β-adrenergic or anti-histaminergic or anti-serotoninergic effect of A<sub>1</sub>-adenosine receptor stimulation in the isolated human atrium. [PDF]
Naunyn Schmiedebergs Arch PharmacolSchwarz R +4 more
europepmc +1 more source
Upregulation of Adenosine A1 Receptors Facilitates Sinoatrial Node Dysfunction in Chronic Canine Heart Failure by Exacerbating Nodal Conduction Abnormalities Revealed by Novel Dual-Sided Intramural Optical Mapping [PDF]
, 2014 Qing Lou +14 more
openalex +1 more source
Thermally Gated Dual‐Cascade Nanozyme for Enhanced Mild‐Temperature Photothermal Therapy
Advanced Science, EarlyView.A thermo‐responsive cascade nanozyme (Ru‐GOx‐PNN) synergistically enhances mild photothermal therapy by dual suppression of HSP70 through ROS‐induced lipid peroxidation and ATP depletion. This intelligent system effectively overcomes thermotolerance and amplifies apoptosis, offering a safe and precise strategy for tumor treatment.
Shuyu Wang +7 more
wiley +1 more source
Synthesis and Biological Evaluation of 5'-Deoxy-adenosine Derivatives as A<sub>3</sub> Adenosine Receptor Ligands. [PDF]
ACS Med Chem LettKim M +9 more
europepmc +1 more source