Results 321 to 330 of about 2,712,589 (407)

A2A adenosine receptor protects tumors from antitumor T cells

Proceedings of the National Academy of Sciences of the United States of America, 2006
A. Ohta, E. Gorelik, Simon J. Prasad, F. Ronchese, D. Lukashev, M. Wong, Xiaojun Huang, Sheila A. Caldwell, Kebin Liu, Patrick T. Smith, Jiang-fan Chen, E. Jackson, S. Apasov, S. Abrams, M. Sitkovsky   +14 more
semanticscholar   +1 more source

Engineering antibodies with cancer‐associated binding sites

BMEMat, EarlyView.
This review describes antibodies that perform direct/indirect roles in cancer treatment by binding to effective targets and discusses how antibodies kill tumors and modulate tumor microenvironment through these targets. The classification of expression systems for antibody production is summarized to guide appropriate selection based on different ...
Yinqi Tian, Yumeng Pan, Yingchun Zhang, Fangling Wang, Zejun Wang   +4 more
wiley   +1 more source

A novel A2a adenosine receptor inhibitor effectively mitigates hepatic fibrosis in a metabolic dysfunction-associated steatohepatitis mouse model. [PDF]

Int J Biol Sci
Park S, Hwang S, Sun J, Jeon KH, Sheen N, Shin S, Kim TH, Lee YS, Seo W, Ryu JS, Kwon Y.   +10 more
europepmc   +1 more source

Unveiling the complexity of cellular senescence in cancers: From mechanism to therapeutic opportunities

BMEMat, EarlyView.
This review highlights the complex roles of cellular senescence in cancer progression and suppression, discusses the mechanisms and regulatory pathways involved, and evaluates the efficacy of the “One‐Two punch” sequential treatment approach while addressing emerging challenges in this novel therapeutic strategy.
Qiuming Pan, Ye Zhu, Zhi Ye, Huayang Zhang, Junxi Wang, Guozhong Yi, Zhiyong Li, Rongyang Xu, Luyao Wang, Zhenzhen Wu, Songtao Qi, Guanglong Huang, Shanqiang Qu   +12 more
wiley   +1 more source

Adenosine A2A receptor blockade reverts hippocampal stress-induced deficits and restores corticosterone circadian oscillation

Molecular Psychiatry, 2013
S. Tolu, S. Tolu, Raphaël Eddine, F. Marti, V. David, Michael Graupner, S. Pons, S. Pons, Mathieu Baudonnat, Marianne Husson, M. Besson, M. Besson, C. Repérant, J. Zemdegs, C. Pagès, Y. A. Hay, B. Lambolez, J. Caboche, B. Gutkin, A. Gardier, J. Changeux, J. Changeux, P. Faure, U. Maskos, U. Maskos   +24 more
semanticscholar   +1 more source

Deciphering the skeletal interoceptive circuitry to control bone homeostasis

BMEMat, EarlyView.
This review introduces the skeletal interoceptive circuitry, covering the ascending signals from bone tissues to the brain (sensors), the central neural circuits that integrate this information and dispatch commands (CPU), and the descending pathways that regulate bone homeostasis (effectors).
Yefeng Wu, Jiusi Guo, Zhen Chen, Fengwei Zhang, Billy Kwok Chong Chow, Zhuofan Chen, Kelvin Wai‐Kwok Yeung, Wei Qiao   +7 more
wiley   +1 more source

Effects of KW-3902, a Novel Adenosine A1-Receptor Antagonist, on Cephaloridine-Induced Acute Renal Failure in Rats

, 1994
Ken Nagashima, Hideaki Kusaka, Kiyoshi Sato, Akira Karasawa   +3 more
openalex   +1 more source

Ecto-5′-Nucleotidase (CD73)-Mediated Formation of Adenosine Is Critical for the Striatal Adenosine A2A Receptor Functions

Journal of Neuroscience, 2013
E. Augusto, Marco Matos, J. Sévigny, A. El-Tayeb, M. Bynoe, C. Müller, R. Cunha, Jiang-fan Chen   +7 more
semanticscholar   +1 more source

Enhancing antitumor immunity through the combination of cholesterolized TLR7 agonist liposomes and radiotherapy: a role for IL‐1β and the inflammasome pathway

Cancer Communications, EarlyView.
Abstract Background Radiotherapy (RT) is a key treatment modality in cancer therapy, utilizing high‐energy radiation to directly kill tumor cells. Recent research has increasingly highlighted RT's potential to indirectly enhance antitumor immunity. However, this immune activation alone often fails to generate sustained systemic antitumor responses.
Xuejiao Han, Yuan Cheng, Dandan Wan, Aqu Alu, Ziqi Zhang, Zhenfei Bi, Manni Wang, Yan Tang, Weiqi Hong, Siyuan Chen, Li Chen, Yuquan Wei   +11 more
wiley   +1 more source

Recent developments in adenosine receptor ligands and their potential as novel drugs.

Biochimica et Biophysica Acta, 2011
C. Müller, K. Jacobson
semanticscholar   +1 more source