Results 341 to 350 of about 2,712,589 (407)

Harnessing Organometallic Gold(III) Complexes as Precision Scaffolds for Next‐Generation Therapeutic and Imaging Agents

ChemBioChem, Accepted Article.
Gold(III) organometallic complexes, particularly cyclometalated Au(III) compounds, have emerged as powerful tools in catalysis and bioinorganic chemistry, offering unique reactivity distinct from their Au(I) counterparts. Among their most interesting transformations, C–S cross‐coupling reactions have become a selective strategy for cysteine arylation ...
Sophie R Thomas, Riccardo Bonsignore
wiley   +1 more source

Repeated caffeine intake suppresses cerebral grey matter responses to chronic sleep restriction in an A₁ adenosine receptor-dependent manner: a double-blind randomized controlled study with PET-MRI. [PDF]

Sci Rep
Lin YS, Lange D, Baur DM, Foerges A, Chu C, Li C, Elmenhorst EM, Neumaier B, Bauer A, Aeschbach D, Landolt HP, Elmenhorst D.   +11 more
europepmc   +1 more source

Fractional Flow Reserve Directed Percutaneous Coronary Intervention Optimization Using High‐Definition Intravascular Ultrasound in Non‐ST‐Segment Elevation Acute Coronary Syndrome Versus Chronic Coronary Syndrome

Catheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT Background Intravascular ultrasound (IVUS)‐guided optimization of suboptimal fractional flow reserve (FFR) following percutaneous coronary intervention (PCI) results in a significant increase in both post‐PCI FFR and minimal lumen and stent areas (MLA and MSA, respectively).
Frederik T. W. Groenland, Tara Neleman, Annemieke C. Ziedses des Plantes, Alessandra Scoccia, Isabella Kardys, Wijnand K. den Dekker, Jeroen M. Wilschut, Roberto Diletti, Nicolas M. Van Mieghem, Joost Daemen   +9 more
wiley   +1 more source

Correction to "Structure-Activity Relationship of Truncated 2,8-Disubstituted-Adenosine Derivatives as Dual A_2A/A₃ Adenosine Receptor Antagonists and Their Cancer Immunotherapeutic Activity". [PDF]

J Med Chem
Kim G, Hou X, Byun WS, Kim G, Jarhad DB, Lee G, Hyun YE, Yu J, Lee CS, Qu S, Warnick E, Gao ZG, Kim JY, Ji S, Shin H, Choi JR, Jacobson KA, Lee HW, Lee SK, Jeong LS.   +19 more
europepmc   +1 more source

The Impact of Hydrostatic Pressure on Fractional Flow Reserve in Saphenous Vein Grafts

Catheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT Background The relationship between height differences related to graft anatomy and physiological pressure indices in coronary bypass grafts has not been studied. We sought to study the impact of hydrostatic pressure on fractional flow reserve (FFR) in saphenous vein grafts (SVGs).
Roel Hoek, Sina Porouchani, Ruben W. de Winter, Yvemarie B. O. Somsen, Pepijn A. van Diemen, Ruurt A. Jukema, Jos W. Twisk, Adriaan Wilgenhof, Alexander W. den Hartog, Niels J. Verouden, Nils R. Planken, Ibrahim Danad, Alexander Nap, Paul Knaapen   +13 more
wiley   +1 more source

Correction: A2B adenosine receptor antagonists rescue lymphocyte activity in adenosine-producing patient-derived cancer models. [PDF]

J Immunother Cancer
europepmc   +1 more source

Diagnostic Accuracy of Angiography‐Derived Murray Law‐Based Quantitative Flow Ratio (μQFR) Versus Pressure‐Derived Fractional Flow Reserve (FFR) in Moderate to Severe Calcified Coronary Lesions—The DIAMOND Study

Catheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT Background Murray law‐based Quantitative Flow Ratio (μQFR) is an innovative AI‐driven method for evaluating coronary lesions using contrast flow velocity estimates. Unlike traditional approaches, μQFR does not require pressure wires or hyperemia induction.
Wesley Bennar, Diego Arroyo, Charline Oppé, Dorian Garin, Laure Allemann, Thaïs Pittet, Pascal Meier, Serban Puricel, Mario Togni, Stephane Cook   +9 more
wiley   +1 more source

PLK4: Master Regulator of Centriole Duplication and Its Therapeutic Potential

Cytoskeleton, EarlyView.
ABSTRACT Centrosomes catalyze the assembly of a microtubule‐based bipolar spindle, essential for the precise chromosome segregation during cell division. At the center of this process lies Polo‐Like Kinase 4 (PLK4), the master regulator that controls the duplication of the centriolar core to ensure the correct balance of two centrosomes per dividing ...
Muhammad Hamzah, Franz Meitinger, Midori Ohta   +2 more
wiley   +1 more source

Risk of colorectal cancer and cancer‐related mortality in type 2 diabetes patients treated with metformin, SGLT‐2 inhibitors, or their combination

Cancer Communications, EarlyView.
Xianhua Mao, Ka‐Shing Cheung, Jing‐Tong Tan, Lung‐Yi Mak, Chi‐Ho Lee, Ho Ming Cheng, Rex Wan‐Hin Hui, Esther Wai Yin Chan, Philip Leung‐Ho Yu, Man‐Fung Yuen, Wai K Leung, Wai‐Kay Seto   +11 more
wiley   +1 more source

First Phosphonic‐Type Inhibitors and Activity‐Based Probes Specific to the O'nyong‐nyong Virus Capsid Protease

ChemMedChem, EarlyView.
The serine capsid protease (CP) catalyzes a crucial process of the alphaviral replication cycle; therefore, it constitutes an interesting therapy target. Herein, the O'nyong‐nyong virus CP profile activity with a specific fluorogenic substrate is analyzed and examines the inhibitory activity of a new series of phosphonic analogs of tryptophan and ...
Karolina Torzyk‐Jurowska, Agnieszka Łupicka‐Słowik, Renata Grzywa, Yuliya Chykunova, Krzysztof Pyrć, Marcin Sieńczyk   +5 more
wiley   +1 more source