Results 351 to 360 of about 2,801,899 (401)

Adenosine and adenosine receptors in colorectal cancer

International Immunopharmacology, 2020
CD39 (nucleoside triphosphate diphosphohydrolase) and Ecto-5-nucleotidase (CD73) have been recognized as important factors mediating various pathological and physiological responses in the tumor microenvironment. Elevated expression of CD73 and CD39 is correlated with the over-production of adenosine in the tumor region.
Farnaz, Hajizadeh, Ali, Masjedi, Sima, Heydarzedeh Asl, Fariba, Karoon Kiani, Makwan, Peydaveisi, Ghasem, Ghalamfarsa, Farhad, Jadidi-Niaragh, Andrey, Sevbitov   +7 more
openaire   +2 more sources

Adenosine Receptors and Inflammation

2009
Extracellular adenosine is produced in a coordinated manner from cells following cellular challenge or tissue injury. Once produced, it serves as an autocrine- and paracrine-signaling molecule through its interactions with seven-membrane-spanning G-protein-coupled adenosine receptors.
Michael R, Blackburn, Constance O, Vance, Eva, Morschl, Constance N, Wilson   +3 more
openaire   +2 more sources

Multi-Objective Evolutionary Design of Adenosine Receptor Ligands

Journal of Chemical Information and Modeling, 2012
A novel multiobjective evolutionary algorithm (MOEA) for de novo design was developed and applied to the discovery of new adenosine receptor antagonists. This method consists of several iterative cycles of structure generation, evaluation, and selection.
E. V. D. Horst, P. Marqués-Gallego, T. Mulder-Krieger, J. V. Veldhoven, J. Kruisselbrink, Alexander Aleman, M. Emmerich, J. Brussee, A. Bender, A. IJzerman   +9 more
semanticscholar   +1 more source

Selective adenosine A2A receptor antagonists

Il Farmaco, 2001
In the early 1990s it became clear that the A2A adenosine receptor had characteristics that made it distinct from the other A1, A2B and A3 adenosine receptors. Great progress has been made with the discovery of selective A2A receptor antagonists. A variety of synthetic substitutions on the xanthine moiety led the chemists of Kyowa-Hakko to discover ...
BARALDI, Pier Giovanni, MONOPOLI A, CACCIARI, Barbara, BARALDI PG   +3 more
openaire   +2 more sources

Adenosine Receptors on Human Lymphocytes

1986
Evidence is accumulating that adenosine functions as an important immunoregulatory autacoid (1,2). Adenosine inhibits the mitotic response of human lymphocytes (3,4), lymphocyte-mediated cytolysis (5), superoxide anion generation by neutrophils (6), platelet aggregation (7) and mediator release from human basophils (8-10). The nucleoside has been shown
MARONE, GIANNI, R. PETRACCA, S. VIGORITA, M. PLAUT   +3 more
openaire   +4 more sources

Adenosine receptors

Neuropharmacology, 1995
T M, Palmer, G L, Stiles
openaire   +2 more sources

Adenosine and ATP Receptors

2007
Adenosine and ATP, via P1 and P2 receptors respectively, can modulate pain transmission under physiological, inflammatory, and neuropathic pain conditions. Such influences reflect peripheral and central actions and effects on neurons as well as other cell types.
openaire   +2 more sources

Adenosine A2B Receptors

Pharmacological Reviews, 1997
I, Feoktistov, I, Biaggioni
openaire   +2 more sources

A3 Adenosine Receptor Antagonists

Mini-Reviews in Medicinal Chemistry, 2001
During the past years a number of potent and selective antagonists for the human A(3) adenosine receptor (AR) have been developed, including tricyclic compounds, such as triazoloquinazoline, pyrazolo-triazolopyridine, imidazopurinone, triazoloquinoxaline and pyrazoloquinoline derivatives.
openaire   +2 more sources

Systemic therapy for hormone receptor‐positive/human epidermal growth factor receptor 2‐negative early stage and metastatic breast cancer

Ca-A Cancer Journal for Clinicians, 2023
Laura A Huppert, Hope S Rugo
exaly