Results 71 to 80 of about 17,634 (253)

Myofibre Density Reveals a Critical Threshold Around Age 6 in Steroid‐Naïve Duchenne Muscular Dystrophy: A Retrospective Observational Study

Neuropathology and Applied Neurobiology, Volume 52, Issue 2, April 2026.
We analysed archival muscle biopsies of steroid‐naïve patients with Duchenne muscular dystrophy (DMD), proposing a novel, simple metric: myofibre density (MFD). MFD sharply declines until age 6, identifying a critical threshold around this age. MFD provides a sensitive, reproducible biomarker for early disease progression, highlighting a potential ...
Tetsuhiro Yamakado, Yuka Ishikawa, Koki Ise, Lei Wang, Yoshitaka Oda, Masumi Tsuda, Taichi Kimura, Masayoshi Nagao, Manabu Ito, Shinya Tanaka, Zen‐ichi Tanei   +10 more
wiley   +1 more source

Inflammation in Idiopathic Intracranial Hypertension: An Immunometabolic Mechanistic Framework and Clinical Implications

CNS Neuroscience &Therapeutics, Volume 32, Issue 3, March 2026.
Systemic metabolic dysfunction and comorbidities may act as upstream modulators converging on inflammatory activation, which is closely intertwined with excessive CSF production and impaired clearance, potentially contributing to sustained ICP elevation.
Guangyu Han, Jiahao Song, Shuling Wan, Xunming Ji, Da Zhou, Ran Meng   +5 more
wiley   +1 more source

1‐Methylcyclopropene Containing‐Paper Enhances the Storability of Anxi Persimmon by Regulating Energy Metabolism

Future Postharvest and Food, Volume 3, Issue 1, Page 16-26, March 2026.
1‐Methylcyclopropene (1‐MCP) containing‐paper delayed the color change and maintained higher rate of commercially acceptable fruit in Anxi persimmons during storage were attributed to the increased activities of H+‐ATPase, Ca2+‐ATPase, and Mg2+‐ATPase and higher levels of ATP content and energy charge (EC).
Lingzhen Zeng, Lili Shi, Yuzhao Lin, Yixiong Lin, Hetong Lin, Hui Wang   +5 more
wiley   +1 more source

A comparison of an ATPase from the archaebacterium Halobacterium saccharovorum with the F1 moiety from the Escherichia coli ATP Synthase [PDF]

A purified ATPase associated with membranes from Halobacterium saccharovorum was compared with the F sub 1 moiety from the Escherichia coli ATP Synthase.
Hochstein, Lawrence I., Stan-Lotter, Helga   +1 more
core   +1 more source

Assessment of the level of muscular strength and volume in physically active English adults [PDF]

, 2012
The aim of this study is to describe the muscular volume and strength of different body segments from a sample of 19 English male participants, with a mean age of 43.84 (±11.62).
Leyton Román, Marta, Luis del Campo, Vicente, Morenas Martín, Jesús, Roldán Romero, Alba   +3 more
core   +3 more sources

Biomarkers for the estimation of isoproterenol‐induced myocardial infarction: A review of key parameters

Journal of Intelligent Medicine, Volume 3, Issue 1, Page 47-68, March 2026.
Abstract The isoproterenol‐induced myocardial infarction model is a well‐established experimental approach for studying cardiac injury and testing potential protective treatments. By overstimulating beta‐adrenergic receptors, this model closely reproduces key features of human heart attacks, including oxidative damage, calcium imbalance, inflammatory ...
Bushra Imran, Tarique Mahmood, Farogh Ahsan, Shahzadi Bano, Vaseem Ahamad Ansari, Mohd Adnan   +5 more
wiley   +1 more source

Chemotherapeutic efficacy of curcumin against plasma and cardio-hepatorenal electrolyte disruption in dichlorvos-challenged rats via augmentation of Na⁺/K⁺-ATPase and Ca²⁺/Mg²⁺-ATPase activities

Journal of Trace Elements and Minerals
Background: Dichlorvos (2,2-dichlorovinyl dimethyl phosphate or DDVP) is an effective organophosphate pesticide extensively employed in various pest management applications. However, it elicits cytotoxicity.
Adio J. Akamo, Boluwatife A. Olagunju, Iyabode A. Kehinde, Naomi M. Akamo, Adetutu O. Ojelabi, Ofem E. Eteng, Ibiyemi O. Opowoye, Adedayo A. Adebisi, Taiwo S. Oguntona, Mushafau A. Akinsanya, Tobi S. Adekunbi, Olufemi M. Ajagun-Ogunleye, Opeyemi E. Popoola, Jacob K. Akintunde, Oluseyi A. Akinloye   +14 more
doaj   +1 more source

The NLRP3 Inflammasome: Mechanisms of Activation, Regulation, and Therapeutic Opportunities

MedComm, Volume 7, Issue 3, March 2026.
Diverse diseases converge on NLRP3. We depict a discovery‐to‐clinic track: high‐throughput/phenotypic screens, structure‐guided design, and modality innovation (allosteric inhibitors, interface blockers, degraders) deliver third‐generation, disease‐tailored NLRP3 control.
Chan Zou, Shilong Jiang, Hui Li, Kai Zhao, Dongshen Cao, Guoping Yang   +5 more
wiley   +1 more source

Proton pump inhibitors (PPIs) impact on tumour cell survival, metastatic potential and chemotherapy resistance, and affect expression of resistance-relevant miRNAs in esophageal cancer [PDF]

, 2014
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work ...
Borchardt, C, Burgers, A, Haier, Jorg, Hummel, Richard, Hussey, Damian James, Lidner, K, Schopp, M, Stock, C   +7 more
core   +1 more source

High‐Throughput Platform for Discovery of Chemical Inhibitors of Heat Shock Protein 70 (Hsp70): Adaptation for the Specialized Bacterial HscA–HscB–IscU Complex

Chemical Biology &Drug Design, Volume 107, Issue 3, March 2026.
The HscA–HscB–IscU system functions in iron–sulfur (Fe‐S) cluster biogenesis in bacteria and fungi, including pathogenic strains. Here, we describe a high‐throughput screen (HTS) to measure inorganic phosphate release from the ATPase HscA within this reconstituted, multi‐protein complex.
Arielle Shkedi, Aneta Grabinska‐Rogala, Jason Hernandez, Rafał Dutkiewicz, Jaroslaw Marszalek, Jason E. Gestwicki   +5 more
wiley   +1 more source