Results 51 to 60 of about 17,634 (253)

Cardiac remodeling and arrhythmia in a mouse model of Depdc5 haploinsufficiency

Epilepsia, EarlyView.
Abstract Objective Some ion channel genes linked to developmental and epileptic encephalopathy (DEE) are also linked to cardiac arrhythmia, leading to the hypothesis that predisposition to cardiac arrhythmias may contribute to the complex disease presentation of DEE and possibly to the mechanism of sudden unexpected death in epilepsy.
Roberto Ramos‐Mondragon, Shuyun Wang, Qinghua Liu, Chunling Chen, Alexander M. Greiner, Abigail M. Marx, Maya Shih, Jack M. Parent, Barry London, Lori L. Isom   +9 more
wiley   +1 more source

Road to Ruin: Targeting Proteins for Degradation in the Endoplasmic Reticulum [PDF]

, 2011
Some nascent proteins that fold within the endoplasmic reticulum (ER) never reach their native state. Misfolded proteins are removed from the folding machinery, dislocated from the ER into the cytosol, and degraded in a series of pathways collectively ...
Ploegh, Hidde, Smith, Melanie H., Weissman, Jonathan S.   +2 more
core   +1 more source

The pharmacokinetics and safety of vonoprazan in adolescents and children with gastroesophageal reflux disease

Journal of Pediatric Gastroenterology and Nutrition, EarlyView.
Abstract Objectives Vonoprazan, a potassium‐competitive acid blocker, provides more rapid, potent, and durable elevations in gastric pH than proton pump inhibitors in adults and may be a treatment option for adolescents and children with gastroesophageal reflux disease (GERD).
Darcy J. Mulford, David A. Gremse, Yu‐Ming Chang, Eckhard Leifke, Thomas Wagner, Axel Facius, Galen Witt   +6 more
wiley   +1 more source

Red blood cell membrane proteome as a reporter of disease severity, transfusion impact and genetic background in transfusion‐dependent β‐thalassaemia

British Journal of Haematology, EarlyView.
Summary Omics technologies have transformed research in haemoglobinopathies, yet the proteome of RBCs remains largely unexplored in transfusion‐dependent thalassaemia (TDT). In this proteomic analysis, Red blood cell (RBC) membranes from 48 adults with TDT were compared with healthy controls.
Konstantina Theocharaki, Sophia Delicou, Aikaterini Ntzoura‐Kani, Nikolaos Simantiris, Marianna Politou, Veroniki Komninaka, Martina Samiotaki, Jerome Zoidakis, Marianna H. Antonelou   +8 more
wiley   +1 more source

Sirt1 carboxyl-domain is an ATP-repressible domain that is transferrable to other proteins [PDF]

, 2017
Sirt1 is an NAD(+)-dependent protein deacetylase that regulates many physiological functions, including stress resistance, adipogenesis, cell senescence and energy production.
A Brunet, AJ Lam, AM Davenport, AW Lau, BE Haley, BP Hubbard, C Chang, C Escande, CG Nichols, CP Hsu, D Cao, E Langley, EJ Kim, F Ghisays, F Picard, F Yeung, G Afshar, G Boily, G Lazzarino, H Dai, H Kang, H Kang, H Vaziri, H Zhao, HS Ghosh, IH Lee, J Chen, J Luo, J Yuan, JA Baur, JE Kim, JL Cole, JS Smith, JT Rodgers, K Hasegawa, K Zhao, KM Atkins, L Guarente, LA Gustafson, M Lagouge, M Pan, M Viswanathan, MC Haigis, MC Motta, MI Bak, MI Bak, ML Lindstrom, NC Yang, P Schuck, R Ghirlando, R Mayoral, S Imai, S Nemoto, S Perrod, S Prasad, SD Westerheide, SM Jeon, T Bouras, T Kondo, V Nin, W Zhao, WW Cleland, WY Chen, X Liu, Y Yang   +64 more
core   +1 more source

A Formalin‐Inactivated Vaccine Enhances Survival and Mitigates Horizontal Transmission of Red Sea Bream Iridovirus (RSIV) in Rock Bream (Oplegnathus fasciatus): Insights From Viability Quantitative PCR

Journal of Fish Diseases, EarlyView.
ABSTRACT Formalin‐inactivated vaccines are widely employed as a primary preventive strategy against red sea bream iridoviral disease (RSIVD), which poses a substantial economic threat to the aquaculture of rock bream (Oplegnathus fasciatus). However, conventional quantitative PCR (qPCR) cannot differentiate infectious virions from noninfectious vaccine
Sung‐Bin Moon, Gyoungsik Kang, HyeongJin Roh, Yoonhang Lee, Min‐Jae Kim, Min‐Young Sohn, Ha‐Jeong Son, Chan‐Il Park, Kyung‐Ho Kim   +8 more
wiley   +1 more source

Protein kinase N2 regulates AMP kinase signaling and insulin responsiveness of glucose metabolism in skeletal muscle [PDF]

, 2017
Insulin resistance is central to the development of type 2 diabetes and related metabolic disorders. Because skeletal muscle is responsible for the majority of whole body insulin-stimulated glucose uptake, regulation of glucose metabolism in this tissue ...
Massart, Julie, Riedl, Isabelle, Ruby, Maxwell A, Zierath, Juleen R, Åhlin, Marcus   +4 more
core   +1 more source

Supplementary Figure 3 from Inhibition of the Sodium Potassium Adenosine Triphosphatase Pump Sensitizes Cancer Cells to Anoikis and Prevents Distant Tumor Formation [PDF]

, 2023
Craig D. Simpson, Imtiaz A. Mawji, Kika Anyiwe, Moyo A. Williams, Xiaoming Wang, Amudha L. Venugopal, Marcela Gronda, Rose Hurren, Sonia Cheng, Stefano Serra, Reza Beheshti Zavareh, Alessandro Datti, Jeffrey L. Wrana, Shereen Ezzat, Aaron D. Schimmer   +14 more
openalex   +1 more source

Sympathetic stimulation can compensate for hypocalcaemia‐induced bradycardia in human and rabbit sinoatrial node cells

The Journal of Physiology, EarlyView.
Abstract figure legend AC: adenylyl cyclase, APT: adenosine triphosphate, AMP: adenosine monophosphate, cAMP: cyclic adenosine monophosphate, PDE: phosphodiesterase, PKA: protein kinase A, PPT: protein phosphatase, P: phosphorylation, RyR: ryanodine receptor, SERCA: sarcoplasmic/endoplasmic reticulum Ca2+‐adenosine triphosphatase, SR: sarcoplasmic ...
Moritz Linder, Tomas Stary, Gergő Bitay, Norbert Nagy, Axel Loewe   +4 more
wiley   +1 more source

An electron microscopic study on the red, white and inter­mediate muscle fibers of mouse [PDF]

, 1964
An electon microscopic study on the structural differences among the red, white and intermediate muscle fibers of mice was made and the following results were obtained. 1.
Ogata, Takuro
core   +1 more source