Results 61 to 70 of about 448,144 (397)
Viruses, 2021 GS-441524 is an adenosine analog and the parent nucleoside of the prodrug remdesivir, which has received emergency approval for treatment of COVID-19. Recently, GS-441524 has been proposed to be effective in the treatment of COVID-19, perhaps even being ...
Henrik Berg Rasmussen +6 more
doaj +1 more source
Enzymatic regeneration of adenosine triphosphate cofactor [PDF]
, 1974 Regenerating adenosine triphosphate (ATP) from adenosine diphosphate (ADP) by enzymatic process which utilizes carbamyl phosphate as phosphoryl donor is technique used to regenerate expensive cofactors.
Marshall, D. L.
core +1 more source
High-Fidelity DNA Sensing by Protein Binding Fluctuations [PDF]
Phys Rev Lett. 2004 Dec 17;93(25):258103, 2010 One of the major functions of RecA protein in the cell is to bind single-stranded DNA exposed upon damage, thereby triggering the SOS repair response.We present fluorescence anisotropy measurements at the binding onset, showing enhanced DNA length discrimination induced by adenosine triphosphate consumption.
arxiv +1 more source
Mapping Hsp104 interactions using cross‐linking mass spectrometry
FEBS Open Bio, EarlyView.This study examines how cross‐linking mass spectrometry can be utilized to analyze ATP‐induced conformational changes in Hsp104 and its interactions with substrates. We developed an analytical pipeline to distinguish between intra‐ and inter‐subunit contacts within the hexameric homo‐oligomer and discovered contacts between Hsp104 and a selected ...
Kinga Westphal +3 more
wiley +1 more source
Microglia modulate the cerebrovascular reactivity through ectonucleotidase CD39
Nature CommunicationsMicroglia and the border-associated macrophages contribute to the modulation of cerebral blood flow, but the mechanisms have remained uncertain.
Zhongxiao Fu +17 more
doaj +1 more source
Altered chemomechanical coupling causes impaired motility of the kinesin-4 motors KIF27 and KIF7. [PDF]
, 2018 Kinesin-4 motors play important roles in cell division, microtubule organization, and signaling. Understanding how motors perform their functions requires an understanding of their mechanochemical and motility properties.
Blasius, T Lynne +7 more
core +2 more sources
Equation-of-motion MLCCSD and CCSD-in-HF oscillator strengths and their application to core excitations [PDF]
arXiv, 2020 We present an implementation of equation-of-motion oscillator strengths for the multilevel CCSD (MLCCSD) model where CCS is used as the lower level method (CCS/CCSD). In this model, the double excitations of the cluster operator are restricted to an active orbital space, whereas the single excitations are unrestricted.
arxiv
Footprint traversal by ATP-dependent chromatin remodeler motor [PDF]
Physical Review E, VOL.85, 041902 (2012), 2011 ATP-dependent chromatin remodeling enzymes (CRE) are bio-molecular motors in eukaryotic cells. These are driven by a chemical fuel, namely, adenosine triphosphate (ATP). CREs actively participate in many cellular processes that require accessibility of specific segments of DNA which are packaged as chromatin. The basic unit of chromatin is a nucleosome
arxiv +1 more source
FEBS Open Bio, EarlyView.Measuring AMP‐activated protein kinase (AMPK) activity in vitro is crucial for testing AMPK activators or inhibitors with therapeutic potential. Here, we report an enzyme‐linked immunosorbent assay (ELISA)‐based AMPK activity assay with simple steps and high sensitivity, which offers a simple, robust, and cost‐effective alternative to traditional ...
Trezze P. Nguyen, Shangze Lyu, Yang Liu
wiley +1 more source
Cyclosporine and methotrexate-related pharmacogenomic predictors of acute graft-versus-host disease
Haematologica, 2015 Effective immunosuppression is mandatory to prevent graft-versus-host disease and to achieve a successful clinical outcome of hematopoietic stem cell transplantation.
Isabelle Laverdière +12 more
doaj +1 more source