Results 51 to 60 of about 250,818 (300)

Visual and Plasmon Resonance Absorption Sensor for Adenosine Triphosphate Based on the High Affinity between Phosphate and Zr(IV)

Sensors, 2016
Zr(IV) can form phosphate and Zr(IV) (–PO32−–Zr4+–) complex owing to the high affinity between Zr(IV) with phosphate. Zr(IV) can induce the aggregation of gold nanoparticles (AuNPs), while adenosine triphosphate(ATP) can prevent Zr(IV)-induced ...
Wenjing Qi, Zhongyuan Liu, Wei Zhang, Mohamed Ibrahim Halawa, Guobao Xu   +4 more
doaj   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Microglia modulate the cerebrovascular reactivity through ectonucleotidase CD39

Nature Communications
Microglia and the border-associated macrophages contribute to the modulation of cerebral blood flow, but the mechanisms have remained uncertain.
Zhongxiao Fu, Mallikarjunarao Ganesana, Philip Hwang, Xiao Tan, Melissa Marie Kinkaid, Yu-Yo Sun, Emily Bian, Aden Weybright, Hong-Ru Chen, Katia Sol-Church, Ukpong B. Eyo, Clare Pridans, Francisco J. Quintana, Simon C. Robson, Pankaj Kumar, B. Jill Venton, Anne Schaefer, Chia-Yi Kuan   +17 more
doaj   +1 more source

Cobra neurotoxin produces central analgesic and hyperalgesic actions via adenosine A and A receptors

Molecular Pain, 2017
Cobra neurotoxin, a short-chain peptide isolated from snake venom of Naja naja atra , showed both a central analgesic effect and a hyperalgesic effect in mice tests.
Chuang Zhao, Jun Zhao, Qian Yang, Yong Ye   +3 more
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Phosphorylation of Myosin by Adenosine Triphosphate [PDF]

Nature, 1948
THE study of the interaction between actomyosin and adenosine triphosphate has hitherto given evidence of physical changes in the protein and of its enzymic activity. Very little was known, however, of chemical changes in the protein molecule accompanying the physical effects.
FRITZ BUCHTHAL, ADAM DEUTSCH, GUSTAV G. KNAPPEIS, AGNETE MUNCH-PETERSEN   +3 more
openaire   +2 more sources

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

The yin and yang functions of extracellular ATP and adenosine in tumor immunity

Cancer Cell International, 2020
Extracellular adenosine triphosphate (eATP) and its main metabolite adenosine (ADO) constitute an intrinsic part of immunological network in tumor immunity.
Li-li Feng, Yi-qing Cai, Ming-chen Zhu, Li-jie Xing, Xin Wang   +4 more
doaj   +1 more source

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source