Results 61 to 70 of about 250,818 (300)

Identification of functionally important residues of the rat P2X4 receptor by alanine scanning mutagenesis of the dorsal fin and left flipper domains. [PDF]

PLoS ONE, 2014
Crystallization of the zebrafish P2X4 receptor in both open and closed states revealed conformational differences in the ectodomain structures, including the dorsal fin and left flipper domains.
Vendula Tvrdonova, Milos B Rokic, Stanko S Stojilkovic, Hana Zemkova   +3 more
doaj   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

A label-free logic gate hairpin aptasensor for sensitive detection of ATP based on graphene oxide and PicoGreen dye

Journal of Analytical Science and Technology, 2021
Background In this paper, a simple, enzyme-free, label-free fluorescence, high sensitivity logic gate hairpin aptasensor was developed for adenosine triphosphate (ATP) detection based on graphene oxide (GO) and PicoGreen dye.
Jingjing Zhang, Handan Xu, Chunhui Li, Yilin Wang, Debing Liu, Shenghe Zhao   +5 more
doaj   +1 more source

Cellular Uptake and Intracellular Phosphorylation of GS-441524: Implications for Its Effectiveness against COVID-19

Viruses, 2021
GS-441524 is an adenosine analog and the parent nucleoside of the prodrug remdesivir, which has received emergency approval for treatment of COVID-19. Recently, GS-441524 has been proposed to be effective in the treatment of COVID-19, perhaps even being ...
Henrik Berg Rasmussen, Gesche Jürgens, Ragnar Thomsen, Olivier Taboureau, Kornelius Zeth, Poul Erik Hansen, Peter Riis Hansen   +6 more
doaj   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Resetting intrinsic purinergic modulation of neural activity: an associative mechanism? [PDF]

, 2002
The purines, ATP and adenosine, control the rundown and termination of swimming in the Xenopus embryo. This intrinsic purinergic modulation, unavoidably present during every swimming episode, could lead to stereotyped inflexible behavior and consequently
Dale, Nicholas, Nicholas Dale
core   +1 more source

The impact of and changes in the oxidative status in the post-injury period following nonpenetrating traumatic brain injuries

Journal of International Medical Research
Objective In the pathogenesis of the post-injury period following nonpenetrating traumatic brain injuries (TBIs; post-TBIs), pathological metabolic changes in the oxidative status are important, as a complete understanding of their interactions can ...
Yevgeniya Lekomtseva, Andrey Belousov, Tkachenko Vitaliy   +2 more
doaj   +1 more source

Extracellular nucleotides mediate viral central nervous system infections: Key alarmins of neuroinflammation and neurodegeneration

Neural Regeneration Research
Recent increases in infectious diseases affecting the central nervous system have raised concerns about their role in neuroinflammation and neurodegeneration.
Raíssa Leite-Aguiar, Elaine Paiva-Pereira, Robson Coutinho-Silva, Cláudia Pinto Figueiredo, Luiz Eduardo Baggio Savio   +4 more
doaj   +1 more source

Diglyceride kinase in human platelets

Journal of Lipid Research, 1973
Human platelets contain diglyceride kinase, an enzyme that catalyzes the phosphorylation of diacylglycerol by adenosine 5′-triphosphate to yield phosphatidic acid.
Frank L. Call, II, Mary Rubert
doaj   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source