Results 31 to 40 of about 160,806 (161)

Identification of functionally important residues of the rat P2X4 receptor by alanine scanning mutagenesis of the dorsal fin and left flipper domains. [PDF]

PLoS ONE, 2014
Crystallization of the zebrafish P2X4 receptor in both open and closed states revealed conformational differences in the ectodomain structures, including the dorsal fin and left flipper domains.
Vendula Tvrdonova, Milos B Rokic, Stanko S Stojilkovic, Hana Zemkova   +3 more
doaj   +1 more source

A label-free logic gate hairpin aptasensor for sensitive detection of ATP based on graphene oxide and PicoGreen dye

Journal of Analytical Science and Technology, 2021
Background In this paper, a simple, enzyme-free, label-free fluorescence, high sensitivity logic gate hairpin aptasensor was developed for adenosine triphosphate (ATP) detection based on graphene oxide (GO) and PicoGreen dye.
Jingjing Zhang, Handan Xu, Chunhui Li, Yilin Wang, Debing Liu, Shenghe Zhao   +5 more
doaj   +1 more source

Cellular Uptake and Intracellular Phosphorylation of GS-441524: Implications for Its Effectiveness against COVID-19

Viruses, 2021
GS-441524 is an adenosine analog and the parent nucleoside of the prodrug remdesivir, which has received emergency approval for treatment of COVID-19. Recently, GS-441524 has been proposed to be effective in the treatment of COVID-19, perhaps even being ...
Henrik Berg Rasmussen, Gesche Jürgens, Ragnar Thomsen, Olivier Taboureau, Kornelius Zeth, Poul Erik Hansen, Peter Riis Hansen   +6 more
doaj   +1 more source

The impact of and changes in the oxidative status in the post-injury period following nonpenetrating traumatic brain injuries

Journal of International Medical Research
Objective In the pathogenesis of the post-injury period following nonpenetrating traumatic brain injuries (TBIs; post-TBIs), pathological metabolic changes in the oxidative status are important, as a complete understanding of their interactions can ...
Yevgeniya Lekomtseva, Andrey Belousov, Tkachenko Vitaliy   +2 more
doaj   +1 more source

Extracellular nucleotides mediate viral central nervous system infections: Key alarmins of neuroinflammation and neurodegeneration

Neural Regeneration Research
Recent increases in infectious diseases affecting the central nervous system have raised concerns about their role in neuroinflammation and neurodegeneration.
Raíssa Leite-Aguiar, Elaine Paiva-Pereira, Robson Coutinho-Silva, Cláudia Pinto Figueiredo, Luiz Eduardo Baggio Savio   +4 more
doaj   +1 more source

Diglyceride kinase in human platelets

Journal of Lipid Research, 1973
Human platelets contain diglyceride kinase, an enzyme that catalyzes the phosphorylation of diacylglycerol by adenosine 5′-triphosphate to yield phosphatidic acid.
Frank L. Call, II, Mary Rubert
doaj   +1 more source

Cyclosporine and methotrexate-related pharmacogenomic predictors of acute graft-versus-host disease

Haematologica, 2015
Effective immunosuppression is mandatory to prevent graft-versus-host disease and to achieve a successful clinical outcome of hematopoietic stem cell transplantation.
Isabelle Laverdière, Chantal Guillemette, Ryad Tamouza, Pascale Loiseau, Regis Peffault de Latour, Marie Robin, Félix Couture, Alain Filion, Marc Lalancette, Alan Tourancheau, Dominique Charron, Gérard Socié, Éric Lévesque   +12 more
doaj   +1 more source

Imaging Adenosine Triphosphate (ATP) [PDF]

The Biological Bulletin, 2016
Adenosine triphosphate (ATP) is a universal mediator of metabolism and signaling across unicellular and multicellular species. There is a fundamental interdependence between the dynamics of ATP and the physiology that occurs inside and outside the cell.
Megha, Rajendran, Eric, Dane, Jason, Conley, Mathew, Tantama   +3 more
openaire   +2 more sources

Baicalin inhibited PANX-1/P2Y6 signaling pathway activation in porcine aortic vascular endothelial cells infected by Glaesserella parasuis

Heliyon
Glaesserella parasuis can induce endothelial barrier damage in piglets, although the mechanism by which this pathogen triggers inflammatory damage remains unclear. Baicalin possesses anti-inflammatory and anti-oxidant activities.
Shulin Fu, Xinyue Tian, Chun Peng, Dan Zhang, Linglu Zhou, Yuzhen Yuan, Jing He, Ling Guo, Yinsheng Qiu, Chun Ye, Yu Liu, Bingbing Zong   +11 more
doaj   +1 more source

Microcystin-LR acute exposure does not alter in vitro and in vivo ATP, ADP and AMP hydrolysis in adult zebrafish (Danio rerio) brain membranes

Journal of Xenobiotics, 2012
Microcystins (MCs) are toxins produced by cyanobacteria during the blooms that could accumulate in aquatic animals and be relocated to higher trophic levels.
Luiza Wilges Kist, Rachel Seemann Fritsch, João Sarkis Yunes, Carla Denise Bonan, Maurício Reis Bogo   +4 more
doaj   +1 more source