Results 61 to 70 of about 3,470 (173)

Plasmodium falciparum spermidine synthase inhibition results in unique perturbation-specific effects observed on transcript, protein and metabolite levels [PDF]

, 2010
BACKGROUND: Plasmodium falciparum, the causative agent of severe human malaria, has evolved to become resistant to previously successful antimalarial chemotherapies, most notably chloroquine and the antifolates.
John VW Becker, Linda Mtwisha, Bridget G Crampton, Stoyan Stoychev, Anna C van Brummelen, Shaun Reeksting, Abraham I Louw, Lyn-Marie Birkholtz, Dalu T Mancama   +8 more
core   +1 more source

A cell fractionation and quantitative proteomics pipeline to enable functional analyses of cotton fiber development

The Plant Journal, Volume 121, Issue 4, February 2025.
SUMMARY Cotton fibers are aerial trichoblasts that employ a highly polarized diffuse growth mechanism to emerge from the developing ovule epidermis. After executing a complicated morphogenetic program, the cells reach lengths over 2 cm and serve as the foundation of a multi‐billion‐dollar textile industry.
Youngwoo Lee, Heena Rani, Eileen L. Mallery, Daniel B. Szymanski   +3 more
wiley   +1 more source

The role of charge in the toxicity of polymer-coated cerium oxide nanomaterials to Caenorhabditis elegans [PDF]

, 2017
This study examined the impact of surface functionalization and charge on ceria nanomaterial toxicity to Caenorhabditis elegans. The examined endpoints included mortality, reproduction, protein expression, and protein oxidation profiles.
Arndt, Devrah A., Butterfield, D. Allan, Cai, Jian, Collin, Blanche E., Klein, Jon B., Nass, Richard, Oostveen, Emily K., Starnes, Daniel L., Triplett, Judy, Tsyusko, Olga V., Unrine, Jason M.   +10 more
core   +3 more sources

Xiaoyu Xiezhuo Decoction Improves Diabetic Kidney Disease by Regulating Cysteine and Methionine Metabolism

Journal of Diabetes Research, Volume 2025, Issue 1, 2025.
Background: Diabetic kidney disease (DKD) is a major complication of diabetes mellitus and has emerged as a significant global public health concern. In this study, we aimed to evaluate the therapeutic effects of the traditional Chinese medicine compound formula, Xiaoyu Xiezhuo decoction (XXD), in a DKD mouse model and to explore its underlying ...
Yuancheng Gao, Yue Ji, Xiang Zhang, Qi Liu, Xinnan Jin, Jiawen Qian, Ziyang Wu, Xiangfu Gao, Shouci Hu, Hongbo Chen, Huantian Cui   +10 more
wiley   +1 more source

The implications of frailty in older adults with epilepsy

Epilepsia Open, Volume 9, Issue 6, Page 2128-2143, December 2024.
Abstract Older adults constitute a large proportion of people with epilepsy (PWE) due to the changing demographics worldwide and epilepsy's natural history. Aging‐related pathophysiological changes lower the tolerance and increase our vulnerability to stressors, which manifests as frailty.
Syeda Amrah Hashmi, Seerat Sachdeva, Udeept Sindhu, Carolyn Tsai, Kalyanchakradhar Bonda, Mark Keezer, Ifrah Zawar, Vineet Punia   +7 more
wiley   +1 more source

TMT-Based Quantitative Proteomics Reveal the Metabolic Changes Underlying Growth Superiority in a Novel Gymnocypris Hybrid, Gymnocypris przewalskii ♀ × G. eckloni ♂

Fishes
Hybrid breeding is an effective approach to generate better varieties and prevent variety degradation. The present study investigated the metabolic changes underlying growth superiority in the novel Gymnocypris hybrid (GH), Gymnocypris przewalskii ♀ (GP)
Yanzhen Dong, Junming Zhou, Dayong Xu, Yun Zhao, Dongming Qi   +4 more
doaj   +1 more source

Differential Abundance of Protein Acylation in Mycobacterium tuberculosis Under Exposure to Nitrosative Stress

PROTEOMICS – Clinical Applications, Volume 18, Issue 6, November 2024.
ABSTRACT Background: Human macrophages generate antimicrobial reactive nitrogen species in response to infection by Mycobacterium tuberculosis (Mtb). Exposure to these redox‐reactive compounds induces stress response in Mtb, which can affect posttranslational modifications (PTM). Methods: Here, we present the global analysis of the PTM acylation of Mtb
Alemayehu Godana Birhanu, Tahira Riaz, Mari Støen, Tone Tønjum   +3 more
wiley   +1 more source

Gibberellin-Stimulation of Rhizome Elongation and Differential GA-Responsive Proteomic Changes in Two Grass Species [PDF]

, 2016
Rapid and extensive rhizome development is a desirable trait for perennial grass growth and adaptation to environmental stresses. The objective of this study was to determine proteomic changes and associated metabolic pathways of gibberellin (GA ...
Bingru Huang, Xiqing Ma
core   +1 more source

Interactions of drosophila cryptochrome

Photochemistry and Photobiology, Volume 100, Issue 5, Page 1339-1358, September/October 2024.
Graphical abstract depicts biotin labeling of proteins in proximity of the DmCRY‐TurboID (TID) and DmCRY‐APEX2 fusion proteins in Drosophila S2 cells. Cells are incubated under darkness or light to investigate DmCRY complexes, which are then identified by mass spectrometry.
Gozde Ozcelik, Mehmet Serdar Koca, Buket Sunbul, Fatma Yilmaz‐Atay, Feride Demirhan, Busra Tiryaki, Kevser Cilenk, Saba Selvi, Nuri Ozturk   +8 more
wiley   +1 more source

The functional roles of S‐adenosyl‐methionine and S‐adenosyl‐homocysteine and their involvement in trisomy 21

BioFactors, Volume 50, Issue 4, Page 709-724, July/August 2024.
Methionine‐homocysteine cycle. The functional groups provided by S‐adenosyl‐methionine (SAM) and their usage are showed. SAH, S‐adenosyl‐homocysteine. Abstract The one‐carbon metabolism pathway is involved in critical human cellular functions such as cell proliferation, mitochondrial respiration, and epigenetic regulation.
Maria Caracausi, Giuseppe Ramacieri, Francesca Catapano, Michela Cicilloni, Bassam Lajin, Maria Chiara Pelleri, Allison Piovesan, Lorenza Vitale, Chiara Locatelli, Gian Luca Pirazzoli, Pierluigi Strippoli, Francesca Antonaros, Beatrice Vione   +12 more
wiley   +1 more source