Results 41 to 50 of about 2,092 (157)

Aptamer-based multiplexed proteomic technology for biomarker discovery [PDF]

, 2010
Interrogation of the human proteome in a highly multiplexed and efficient manner remains a coveted and challenging goal in biology. We present a new aptamer-based proteomic technology for biomarker discovery capable of simultaneously measuring thousands
Urs Ochsner, Nancy Kim, Steven K. Wolk, Singer Britta, Kraemer Stephan, Eaton Bruce E., Zhang Chi, Halladay Dennis, Schneider Daniel, Wilcox Sheri K., Tad H Koch, Alexey Wolfson, Terese Kaske, Fitzwater Tim, Mehan Mike, Gold Larry, Bruce E Eaton, Nelson Sally K., Pietrasiewicz Steve, Sheela Waugh, Jonathan D. Vaught, Shashi Gupta, Koch Tad H., Keeney Tracy R., Forbes Ashley, Jennifer Bertino, Parker Thomas, Wes Mayfield, Watrobka Mike, Thomas Parker, Lollo Bridget, Dalby Andrew B., Vaught Jonathan D., Brian Hicke, Husar Gregory, Rachel M, Dan Nieuwlandt, Ngan Le, John Rohloff, Suzanne Stratford, Edward N Brody, Katilius Evaldas, Martin Stanton, Gupta Shashi, Thale Jarvis, Sheri K. Wilcox, Rohloff John, Sanders Glenn, Gawande Bharat, Hicke Brian, Matt Otis, Susan Jennings, Jonathan D Vaught, Waugh Sheela, Robert Mehler, Dennis Halladay, Tad Koch, Dan Resnicow, Resnicow Daniel I., Deborah Ayers, Andrew Dalby, Trudi Foreman, Stewart Alex, Daniel I. Resnicow, Mayfield Wes, Dan Nieuwl, Gregory Husar, Andrew B. Dalby, Cate Fowler, Weiss Allison, Nieuwlandt Dan, Bock Ashley, Mike Mehan, Jeffrey J. Walker, Allison Weiss, Le Ngan, Nebojsa Janjic, Lindsey Wes, Stratford Suzanne, Larry Gold, Bock Christopher, Janjic Nebojsa, Otis Matt, Kim Nancy, Magda Gunn, Mike Watrobka, Alex Stewart, Steve Pietrasiewicz, Sheri Wilcox, Virginia Cunningham, Kroiss Luke, Mehler Robert, Heilig Joe, Nikrad Malti, Heil Jim, Vrkljan Mike, Jim Heil, Edward N. Brody, Luke Kroiss, Dan Schneider, Jarvis Thale, Goss Meredith, Chi Zhang, Levine Daniel, Daniel I Resnicow, Walker Jeffrey J., Bharat Gaw, Rachel M Ostroff, Sheri K Wilcox, Steven K Wolk, Evaldas Katilius, Tracy R. Keeney, Ayers Deborah, Bharat Gawande, Malti Nikrad, Sattin Sarah, Fowler Cate, Zichi Dom, Sally K. Nelson, Mike Vrkljan, Joe Heilig, Sarah Sattin, Andrew B Dalby, Stanton Martin, Stephan Kraemer, Wes Lindsey, Michele Nelson, Foreman Trudi, Britta Singer, Jeffrey J Walker, Gunn Magda, Steve Wolk, Bruce E. Eaton, Wolfson Alexey, Tim Fitzwater, Nelson Michele, Steve Pietrasiewicz, Carter Jeff, Tad H. Koch, Dom Zichi, Glenn Sanders, Ashley Bock, Bridget Lollo, Tracy R Keeney, Jeff Carter, Ashley Forbes, Dylan Flather, Brody Edward N., Wolk Steven K., Flather Dylan, Alana Sterkel, Sterkel Alana, Meredith Goss, Jennings Susan, Rachel M. Ostroff, Ostroff Rachel M., Bertino Jennifer, Daniel Schneider, Ochsner Urs, Daniel Levine, Sally K Nelson, Christopher Bock   +161 more
core   +2 more sources

CBS, PHGDH and PSAT1 interactive gene network.

, 2016
The differentially expressed genes CBS, PHGDH and PSAT1 interactive network generated automatically using the STRING database (STRING software 9.1) is shown here.
Indira Hewlett (329203), Santanu Biswas (2181154), Viswanath Ragupathy (656191), Sherwin Lee (656192), Krishnakumar Devadas (196381), Owen Wood (196407), Mohan Haleyurgirisetty (2181152)   +6 more
core   +1 more source

Data_Sheet_2_Prognostic Value of Serum Exosomal AHCY Expression in Hepatitis B-Induced Liver Cirrhosis.PDF

, 2021
Objective: We aimed to investigate serum exosomal adenosylhomocysteinase (AHCY) expression in hepatitis B-induced liver cirrhosis (HBV-LC) patients and to determine the prognostic value of serum exosomal AHCY.Methods: We collected serum samples from 100 ...
Hongmei Wang (190581), Cuilin Yan (11380848), Ling Tong (632992), Jiajia Yang (813640), Ying Wang (11406), Minjie Wang (128852)   +5 more
core   +1 more source

Effects of maternal dietary omega-3 polyunsaturated fatty acids and methionine during late gestation on fetal growth, DNA methylation, and mRNA relative expression of genes associated with the inflammatory response, lipid metabolism and DNA methylation in placenta and offspring’s liver in sheep

Journal of Animal Science and Biotechnology, 2020
Background Omega-3 PUFA or methionine (Met) supply during gestation alters offspring physiology. However, the effect of both nutrients on fetal development has not been explored.
Milca Rosa Velazquez, Fernanda Batistel, Juan Manuel Pinos Rodriguez, Alejandro Enrique Relling   +3 more
doaj   +1 more source

Table_1_Prognostic Value of Serum Exosomal AHCY Expression in Hepatitis B-Induced Liver Cirrhosis.XLSX

, 2021
Objective: We aimed to investigate serum exosomal adenosylhomocysteinase (AHCY) expression in hepatitis B-induced liver cirrhosis (HBV-LC) patients and to determine the prognostic value of serum exosomal AHCY.Methods: We collected serum samples from 100 ...
Hongmei Wang (190581), Cuilin Yan (11380848), Ling Tong (632992), Jiajia Yang (813640), Ying Wang (11406), Minjie Wang (128852)   +5 more
core   +1 more source

Extracellular Vesicles From Human Fallopian Tubes Enhance IVF Embryo Development and Contain Functional Proteins Including YWHAZ

Journal of Extracellular Vesicles, Volume 15, Issue 7, July 2026.
ABSTRACT Extracellular vesicles (EVs) in the mammalian oviduct constitute a key maternal regulatory system that maintains redox balance during early embryogenesis, yet their molecular cargo and functional relevance in human embryos remain poorly defined.
Yuehan Li, Wenjing Xiong, Limin Gao, Mingwei Lv, Fei Li, Rui Long, Chang Liu, Jianbo Wei, Meng Wang, Chenlu Zhang, Qiuyu Yu, Na Guo, Lei Jin, Cong Sui   +13 more
wiley   +1 more source

SPROUTS_DB: An Implemented Database of Contaminants for Extracellular Vesicle Proteomics Studies

PROTEOMICS, Volume 26, Issue 7, Page 69-83, July 2026.
ABSTRACT Current proteomics techniques allow rapid identification and quantification of proteins within any given biological source. However, LC–MS/MS proteomics is vulnerable to laboratory and sample‐associated contaminants. Therefore, accurate identification and annotation of such contaminants is crucial for development of reliable databases ...
Maria Gaetana Giovanna Pittalà, Loredana Leggio, Greta Paternò, Elena Giusto, Laura Civiero, Vincenzo Cunsolo, Silvia Vivarelli, Antonella Di Francesco, Emanuele Alpi, Nunzio Iraci, Rosaria Saletti   +10 more
wiley   +1 more source

Multi‐Omics Profiling of the Scaphoideus titanus Yeast‐Like Symbiont Guides the Bioinformatic Discovery of Related Fungal Symbioses in Insects

Environmental Microbiology, Volume 28, Issue 7, July 2026.
Genomic, proteomic and phylogenetic analyses of the obligate yeast‐like symbiont (YLS) associated with Scaphoideus titanus revealed retained metabolic flexibility and a monophyletic origin of insect‐associated YLSs within a free‐living fungal lineage. A novel computational pipeline was used to mine NCBI transcriptomic data and identified new candidate ...
Simona Abbà, Marta Vallino, Alessandro Cicerone, Simona Cirrincione, Beatrice Aiuto, Luciana Galetto, Marika Rossi   +6 more
wiley   +1 more source

Study of mechanism of interaction of truncated isoniazid–nicotinamide adenine dinucleotide adduct against multiple enzymes of Mycobacterium tuberculosis by a computational approach

International Journal of Mycobacteriology, 2015
Objective/Background: Isoniazid (INH) is one of the effective antituberculosis (TB) drugs used for TB treatment. However, most of the drug-resistant Mycobacterium tuberculosis (MTB) clinical strains are resistant to INH, a first-line antituberculous drug.
Lingaraja Jena, Shraddha Deshmukh, Pranita Waghmare, Satish Kumar, Bhaskar C Harinath   +4 more
doaj   +1 more source

Mechanism for enzymatic thioether formation. Mechanism of action of S-adenosylhomocysteinase.

Journal of Biological Chemistry, 1976
Homogeneous S-adenosylhomocysteinase contains tightly bound NAD+. This NAD+ is not dissociable under nondenaturing conditions but can be removed by heat or acid denaturation. Addition of adenosine to the enzyme causes an increase in the absorption at 327 nm which we attribute to NADH formation.
J L, Palmer, R H, Abeles
openaire   +2 more sources