Results 61 to 70 of about 2,006 (160)

ASIP Variants in Livestock: It's Not Black and White

Animal Genetics, Volume 57, Issue 3, June 2026.
ABSTRACT Fur and feather pigmentation play an important role in the survival and reproduction of many species, as well as in selective breeding and agriculture. The synthesis of pigment molecules, eumelanin and pheomelanin, is partially regulated by the agouti signalling protein (ASIP) encoded by the ASIP gene.
Isabella M. Brown, Kylie A. Munyard
wiley   +1 more source

Methionine cycle. [PDF]

, 2020
Differential brain concentrations of metabolites and differential gene expression of enzymatic regulators are observed in the methionine cycle in AD. Lower concentration of choline and higher concentration of SAM are observed in AD in the ITG.
Olga Pletnikova (225888), Chad T. Blackshear (8356251), Cristina Legido-Quigley (718909), Richard O’Brien (3850429), Uma V. Mahajan (8356245), Anup M. Oommen (4797435), Juan C. Troncoso (225906), Sudhir Varma (56982), Vijay R. Varma (4797432), Madhav Thambisetty (133912), Michael E. Griswold (8356248), Yang An (326217), Timothy J. Hohman (8356254)   +12 more
core   +1 more source

Study of mechanism of interaction of truncated isoniazid–nicotinamide adenine dinucleotide adduct against multiple enzymes of Mycobacterium tuberculosis by a computational approach

International Journal of Mycobacteriology, 2015
Objective/Background: Isoniazid (INH) is one of the effective antituberculosis (TB) drugs used for TB treatment. However, most of the drug-resistant Mycobacterium tuberculosis (MTB) clinical strains are resistant to INH, a first-line antituberculous drug.
Lingaraja Jena, Shraddha Deshmukh, Pranita Waghmare, Satish Kumar, Bhaskar C Harinath   +4 more
doaj   +1 more source

Colorectal Precancerous Lesions: Molecular Mechanisms, Research Tools, and Natural Product‐Based Clinical Translation

MedComm – Oncology, Volume 5, Issue 2, June 2026.
This article systematically elucidates the molecular mechanisms of colorectal precancerous lesions, introduces cutting‐edge research tools like multi‐omics and organoids, and highlights the potential and prospects of natural products such as berberine, resveratrol, and curcumin in preventing and intervening in colorectal carcinogenesis by modulating ...
Shunji Liu, Chujuan Cui, Lingdong Kong, Qiang Xu, Haibo Cheng, Lisha Zhou, Yang Sun   +6 more
wiley   +1 more source

Chemical modification of arginine residues of rat liver S-adenosylhomocysteinase.

Journal of Biological Chemistry, 1983
Rat liver S-adenosylhomocysteinase (EC 3.3.1.1) is inactivated by phenylglyoxal following pseudo-first order kinetics. The dependence of the apparent first order rate constant for inactivation on the phenylglyoxal concentration shows that the inactivation is second order in reagent. This fact together with the reversibility of inactivation upon removal
Y, Takata, M, Fujioka
openaire   +2 more sources

A Meta‐Analysis of the Effects of Acute Sleep Deprivation on the Cortical Transcriptome in Rodent Models

Journal of Sleep Research, Volume 35, Issue 3, June 2026.
How does sleep deprivation affect the brain? We performed a meta‐analysis of publicly available transcriptional profiling datasets characterising the effects of sleep deprivation on cortical gene expression (n = 293 mice, 16,290 genes) and validated our results in an independent sample (n = 222 mice).
Cosette A. Rhoads, Megan H. Hagenauer, Jinglin Xiong, Erin Hernandez, Duy Manh Nguyen, Annaka Saffron, Elizabeth Flandreau, Stanley Watson Jr., Huda Akil   +8 more
wiley   +1 more source

An atlas of plant selenium metabolism

New Phytologist, Volume 250, Issue 4, Page 2041-2060, May 2026.
Summary Selenium (Se) is not only a rare and toxic element but also an essential micronutrient for humans and animals that is often in short supply. Terrestrial plants do not require Se, but it can have growth‐promoting or negative effects, depending on the exposure level.
Jeroen van der Woude, Mark G. M. Aarts, Michela Schiavon, Antony van der Ent   +3 more
wiley   +1 more source

Improved red blood cell storage quality of blood from donors carrying the hypermorphic PIMT I120 variant

HemaSphere, Volume 10, Issue 4, April 2026.
Abstract Protein‐l‐isoaspartate O‐methyltransferase (PIMT), encoded by PCMT1, is a repair enzyme that corrects isoaspartyl lesions, preserving protein structure and function. While indispensable for neuronal integrity, its role in red blood cells (RBCs) and transfusion outcomes is incompletely understood.
Shaun Bevers, Aaron V. Issaian, Ariel Hay, Gregory R. Keele, Monika Dzieciatkowska, Julie A. Reisz, Zachary B. Haiman, Travis Nemkov, Daniel Stephenson, Amy L. Moore, Xutao Deng, Mars Stone, Kirk C. Hansen, Steve Kleinman, Philip J. Norris, Michael P. Busch, Bernhard O. Palsson, Nareg H. Roubinian, John Janetzko, Beat Vӧgeli, Grier P. Page, David N. Jones, Morkos A. Henen, Elan Z. Eisenmesser, James C. Zimring, Angelo D'Alessandro   +25 more
wiley   +1 more source

Attenuation of SARS‐CoV‐2 replication and associated inflammation by concomitant targeting of viral and host cap 2'‐O‐ribose methyltransferases [PDF]

, 2022
The SARS‐CoV‐2 infection cycle is a multistage process that relies on functional interactions between the host and the pathogen. Here, we repurposed antiviral drugs against both viral and host enzymes to pharmaceutically block methylation of the viral ...
Vincent Grass, Yiqi Huang, Kümmerer, Beate M, Stukalov, Alexey, Shintaro Yamada, Antonio Piras, Madlen Oelsner, Mühlhofer, Maria‐Teresa, Valter Bergant, Yuriko Tomita, Yamada, Shintaro, Tomita, Yuriko, vom Hemdt, Anja, Stefan Krebs, Kato, Hiroki, Armin Ensser, Hemdt, Anja vom, Shutoku Matsuyama, Manabu Igarashi, Anja vom Hemdt, Matsuyama, Shutoku, Igarashi, Manabu, Wittmann, Sabine, Yuta Tsukamoto, Hirokawa, Takatsugu, Krey, Karsten, Carsten B Schmidt‐Weber, Tsukamoto, Yuta, Huang, Yiqi, Oelsner, Madlen, Sabine Wittmann, Thomas Gramberg, Ensser, Armin, Karsten Krey, Hiroki Kato, Jakwerth, Constanze A, Krebs, Stefan, Grass, Vincent, Teresa Lavacca, Pichlmair, Andreas, Helmut Blum, Alexander Graf, Alexey Stukalov, Beate M Kümmerer, Bergant, Valter, Takatsugu Hirokawa, Thieme, Susanne, Blum, Helmut, Schmidt‐Weber, Carsten B, Susanne Thieme, Graf, Alexander, Maria‐Teresa Mühlhofer, Herrmann, Alexandra, Andreas Pichlmair, Constanze A Jakwerth, Gramberg, Thomas, Alexandra Herrmann, Lavacca, Teresa, Piras, Antonio   +58 more
core   +2 more sources

Proteome analysis of Norway maple (Acer platanoides L.) seeds dormancy breaking and germination: influence of abscisic and gibberellic acids

BMC Plant Biology, 2009
Background Seed dormancy is controlled by the physiological or structural properties of a seed and the external conditions. It is induced as part of the genetic program of seed development and maturation. Seeds with deep physiological embryo dormancy can
Pawłowski Tomasz A
doaj   +1 more source