Results 31 to 40 of about 2,006 (160)

Excess S-adenosylmethionine inhibits methylation via catabolism to adenine

open access: yesCommunications Biology, 2022
S-adenosylmethionine (SAM) is a widely available dietary supplement. Exogenous SAM is catabolized to adenine, an inhibitor of adenosylhomocysteinase, leading to widespread methylation inhibition and disruption of circadian rhythms in vitro and in mice.
Kazuki Fukumoto   +9 more
doaj   +1 more source

Prognostic Value of Serum Exosomal AHCY Expression in Hepatitis B-Induced Liver Cirrhosis

open access: yesFrontiers in Medicine, 2021
Objective: We aimed to investigate serum exosomal adenosylhomocysteinase (AHCY) expression in hepatitis B-induced liver cirrhosis (HBV-LC) patients and to determine the prognostic value of serum exosomal AHCY.Methods: We collected serum samples from 100 ...
Ling Tong   +5 more
doaj   +1 more source

Zika virus remodelled ER membranes contain proviral factors involved in redox and methylation pathways

open access: yesNature Communications, 2023
Zika virus (ZIKV) has emerged as a global health issue, yet neither antiviral therapy nor a vaccine are available. ZIKV is an enveloped RNA virus, replicating in the cytoplasm in close association with ER membranes.
Solène Denolly   +8 more
doaj   +1 more source

Narrow SNP-level intervals of differentiation indicate potential targets of natural selection from the 1900s-focused scan. [PDF]

open access: yes, 2023
PBE for each SNP is plotted across selected top outlier regions that showed narrow peaks of differentiation. These peaks occurred in or near: (A) Adenosylhomocysteinase (Ahcy, or Ahcy13) in region B2, (B) retinal degeneration B (rdgB) in region B8, (C ...
Marcus C. Stensmyr (11722865)   +4 more
core   +1 more source

ITRAQ Proteomic Analysis of Yellow and Black Skin in Jinbian Carp (Cyprinus carpio)

open access: yesLife, 2020
Colors are important phenotypic traits for fitness under natural conditions in vertebrates. Previous studies have reported several functional genes and genetic variations of pigmentation, but the formation mechanisms of various skin coloration remained ...
Xiangchen Ye   +10 more
doaj   +1 more source

Proteomic Investigation of Human Dental Pulp to Identify Individuals Who Are Pregnant. [PDF]

open access: yesProteomics Clin Appl
ABSTRACT Biomolecules preserved in dental pulp are increasingly being used to identify individuals in the context of forensics and archaeology. Despite the vast amount of research into host and pathogen DNA, the potential use of physiologically informative proteins preserved in dental pulp has rarely been studied.
Tsutaya T   +9 more
europepmc   +2 more sources

Differential expression of AHCY in colorectal cancer. [PDF]

open access: yes, 2023
Cancer is a leading cause of death and colorectal cancer is among the most lethal cancers (1, 2). We mined public and published microarray datasets (3, 4) to determine in an unbiased fashion and at the level of the transcriptome genes most ...
Shahan Mamoor
core   +1 more source

AHCY is differentially expressed in central nervous system metastasis in human breast cancer. [PDF]

open access: yes, 2023
Metastasis to the brain occurs in a significant fraction of patients with breast cancer (1-3). We mined published RNA-sequencing and microarray data (4, 5) to compare primary and metastatic tumor transcriptomes for the discovery of genes associated with ...
Shahan Mamoor
core   +1 more source

In Silico Discovery of Candidate Drugs against Covid-19

open access: yesViruses, 2020
Previous studies reported that Angiotensin converting enzyme 2 (ACE2) is the main cell receptor of SARS-CoV and SARS-CoV-2. It plays a key role in the access of the virus into the cell to produce the final infection.
Claudia Cava   +2 more
doaj   +1 more source

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