Preparation of a Brucella multiepitope fusion protein based on bioinformatics and its application in serological diagnosis of human brucellosis [PDF]
Scientific ReportsSummary Brucellosis is a zoonotic infectious disease caused by the Brucella spp., and the enhancement of diagnostic techniques is imperative for effective disease control. Currently, the diagnosis of brucellosis predominantly relies on serological tests,
Guangyu Wang +6 more
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The Role of AHCY Expression in Bladder Urothelial Carcinoma: A Bioinformatics and Experimental Analysis [PDF]
Cancer Management and ResearchShaorui Niu,1 Xiaozhe Zheng,1 Yuyang Yao,1 Yue Dong,2 Yupan Hu,3 Zhiyang Xiao,1 Jiaxue Yang,1 Chengli Jiang,1 Xin Zou,4 Zihao Zou,5 Pang Yang1 1Jiangxi Key Laboratory of Cancer Metastasis and Precision Treatment, Central Laboratory, The First Hospital of
Niu S +10 more
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Substrate specificity of S-Adenosylhomocysteinase
BBA - Proteins and Proteomics, 1983 Abstract S-Adenosylhomocysteinase (SAHase) is irreversibly inactivated by 2′-deoxyadenosine (Hirshfield, M.S. (1979) J. Biol. Chem. 254 , 22–25). In the course of this inactivation, 2′dAd becomes tightly bound to the enzyme, i.e., cannot be removed by gel filtration or dialysis.
Hieronim Jakubowski +2 more
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Selection Signal Analysis Reveals Hainan Yellow Cattle Are Being Selectively Bred for Heat Tolerance [PDF]
AnimalsHainan yellow cattle are indigenous Zebu cattle from southern China known for their tolerance of heat and strong resistance to disease. Generations of adaptation to the tropical environment of southern China and decades of artificial breeding have left ...
Liuhao Wang +8 more
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Metabolic profiling stratifies colorectal cancer and reveals adenosylhomocysteinase as a therapeutic target [PDF]
Nature Metabolism, 2023 Abstract The genomic landscape of colorectal cancer (CRC) is shaped by inactivating mutations in tumour suppressors such as APC , and oncogenic mutations such as mutant KRAS .
Johan Vande Voorde +53 more
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Identification of proteins regulated by chlorogenic acid in an ischemic animal model: a proteomic approach [PDF]
Laboratory Animal Research, 2023 Background Cerebral ischemia is a serious neurological disorder that can lead to high morbidity and mortality. Chlorogenic acid is a polyphenol compound with antioxidant that can regulate proteins in cerebral ischemia.
Murad-Ali Shah, Ju-Bin Kang, Phil-Ok Koh
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Comparative Proteomic Analysis Reveals Proteins Putatively Involved in Toxin Biosynthesis in the Marine Dinoflagellate Alexandrium catenella [PDF]
Marine Drugs, 2013 Alexandrium is a neurotoxin-producing dinoflagellate genus resulting in paralytic shellfish poisonings around the world. However, little is known about the toxin biosynthesis mechanism in Alexandrium. This study compared protein profiles of A.
Da-Zhi Wang +3 more
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The long non-coding RNA lncMYOZ2 mediates an AHCY/MYOZ2 axis to promote adipogenic differentiation in porcine preadipocytes [PDF]
BMC Genomics, 2022 Long non-coding RNAs (lncRNAs) play a vital role in regulating adipogenesis. However, the associated regulatory mechanisms have yet to be described in detail in pig.
Yang Yang +11 more
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Functional and Pathological Roles of AHCY [PDF]
Frontiers in Cell and Developmental Biology, 2021 Adenosylhomocysteinase (AHCY) is a unique enzyme and one of the most conserved proteins in living organisms. AHCY catalyzes the reversible break of S-adenosylhomocysteine (SAH), the by-product and a potent inhibitor of methyltransferases activity.
Pedro Vizán +4 more
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SAM transmethylation pathway and adenosine recycling to ATP are essential for systemic regulation and immune response [PDF]
eLifeDuring parasitoid wasp infection, activated immune cells of Drosophila melanogaster larvae release adenosine to conserve nutrients for immune response.
Pavla Nedbalová +4 more
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