Metabolic profiling stratifies colorectal cancer and reveals adenosylhomocysteinase as a therapeutic target [PDF]
Nature Metabolism, 2023 Abstract The genomic landscape of colorectal cancer (CRC) is shaped by inactivating mutations in tumour suppressors such as APC , and oncogenic mutations such as mutant KRAS .
Johan Vande Voorde +53 more
core +6 more sources
Comparative Proteomic Analysis Reveals Proteins Putatively Involved in Toxin Biosynthesis in the Marine Dinoflagellate Alexandrium catenella [PDF]
Marine Drugs, 2013 Alexandrium is a neurotoxin-producing dinoflagellate genus resulting in paralytic shellfish poisonings around the world. However, little is known about the toxin biosynthesis mechanism in Alexandrium. This study compared protein profiles of A.
Da-Zhi Wang +3 more
doaj +3 more sources
In Ovo injection of betaine affects hepatic cholesterol metabolism through epigenetic gene regulation in newly hatched chicks. [PDF]
PLoS ONE, 2015 Betaine is reported to regulate hepatic cholesterol metabolism in mammals. Chicken eggs contain considerable amount of betaine, yet it remains unknown whether and how betaine in the egg affects hepatic cholesterol metabolism in chicks.
Yun Hu +6 more
doaj +2 more sources
RyR2/IRBIT regulates insulin gene transcript, insulin content, and secretion in the insulinoma cell line INS-1 [PDF]
Scientific Reports, 2022 The role of ER Ca2+ release via ryanodine receptors (RyR) in pancreatic β-cell function is not well defined. Deletion of RyR2 from the rat insulinoma INS-1 (RyR2KO) enhanced IP3 receptor activity stimulated by 7.5 mM glucose, coincident with reduced ...
Kyle E. Harvey +8 more
doaj +2 more sources
STIP1 drives Metabolic Reprogramming in Esophageal Squamous Cell Carcinoma via AHCY‐LDHA Axis
ExplorationGlucose metabolism reprogramming has emerged as a hallmark of cancer. We have reported that high temperature food or drink (>65°C) is the key etiological factors contributing to esophageal squamous cell carcinoma (ESCC) progression.
Guoguo Jin +16 more
doaj +2 more sources
Pharmaceutics, 2022 Alzheimer’s disease (AD), the most common cause of dementia, causes irreversible memory loss and cognitive deficits. Current AD drugs do not significantly improve cognitive function or cure the disease.
Olaia Martínez-Iglesias +4 more
doaj +2 more sources
Selection Signal Analysis Reveals Hainan Yellow Cattle Are Being Selectively Bred for Heat Tolerance
AnimalsHainan yellow cattle are indigenous Zebu cattle from southern China known for their tolerance of heat and strong resistance to disease. Generations of adaptation to the tropical environment of southern China and decades of artificial breeding have left ...
Liuhao Wang +8 more
doaj +2 more sources
Thoracic Aortic Dissection in a Patient With Classical Homocystinuria: Implications for Aortic Surveillance. [PDF]
JIMD RepABSTRACT Classical homocystinuria (OMIM #236300), a rare inherited metabolic disorder caused by cystathionine beta‐synthase (CBS) deficiency, is characterized by markedly elevated homocysteine levels and associated multisystem complications. While the role of homocystinuria in venous thromboembolism is well recognized, there is limited evidence of ...
Chard M, Zhang JS, Turner L.
europepmc +2 more sources
An adenosine 3′:5′‐monophosphate adenosine‐binding protein from mouse liver [PDF]
FEBS Letters, 1978 Sæbø, John, Euland, Per Magne
openaire +4 more sources