Results 1 to 10 of about 2,092 (157)

Bioinformatics identification of adenosylhomocysteinase (AHCY) as a regulator of ferroptosis in nasopharyngeal carcinoma cells via the Hippo-Yes-associated protein (Hippo-YAP) pathway. [PDF]

Transl Cancer Res
Nasopharyngeal carcinoma (NPC) is a widely prevalent malignant tumor with a marked tendency toward metastasis and recurrence. Ferroptosis-related genes (FRGs) are critically involved in the pathogenesis of NPC. This study aims to employ bioinformatics analysis methods to identify key genes influencing the malignant progression of NPC and to investigate
Zheng H, Wang X, Chen Q.
europepmc   +4 more sources

Preparation of a Brucella multiepitope fusion protein based on bioinformatics and its application in serological diagnosis of human brucellosis [PDF]

Scientific Reports
Summary Brucellosis is a zoonotic infectious disease caused by the Brucella spp., and the enhancement of diagnostic techniques is imperative for effective disease control. Currently, the diagnosis of brucellosis predominantly relies on serological tests,
Guangyu Wang, Xinru Qi, Shiqi Zhao, Qichuan Pei, Yixiao Chen, Dehui Yin, Tiansong Zhan   +6 more
doaj   +3 more sources

Substrate specificity of S-Adenosylhomocysteinase

BBA - Proteins and Proteomics, 1983
Abstract S-Adenosylhomocysteinase (SAHase) is irreversibly inactivated by 2′-deoxyadenosine (Hirshfield, M.S. (1979) J. Biol. Chem. 254 , 22–25). In the course of this inactivation, 2′dAd becomes tightly bound to the enzyme, i.e., cannot be removed by gel filtration or dialysis.
Hieronim Jakubowski, Andrzej Guranowski, A Guranowski   +2 more
exaly   +20 more sources

The Role of AHCY Expression in Bladder Urothelial Carcinoma: A Bioinformatics and Experimental Analysis [PDF]

Cancer Management and Research
Shaorui Niu,1 Xiaozhe Zheng,1 Yuyang Yao,1 Yue Dong,2 Yupan Hu,3 Zhiyang Xiao,1 Jiaxue Yang,1 Chengli Jiang,1 Xin Zou,4 Zihao Zou,5 Pang Yang1 1Jiangxi Key Laboratory of Cancer Metastasis and Precision Treatment, Central Laboratory, The First Hospital of
Niu S, Zheng X, Yao Y, Dong Y, Hu Y, Xiao Z, Yang J, Jiang C, Zou X, Zou Z, Yang P   +10 more
doaj   +4 more sources

Identification of proteins regulated by chlorogenic acid in an ischemic animal model: a proteomic approach [PDF]

Laboratory Animal Research, 2023
Background Cerebral ischemia is a serious neurological disorder that can lead to high morbidity and mortality. Chlorogenic acid is a polyphenol compound with antioxidant that can regulate proteins in cerebral ischemia.
Murad-Ali Shah, Ju-Bin Kang, Phil-Ok Koh
doaj   +2 more sources

Functional and Pathological Roles of AHCY

Frontiers in Cell and Developmental Biology, 2021
Adenosylhomocysteinase (AHCY) is a unique enzyme and one of the most conserved proteins in living organisms. AHCY catalyzes the reversible break of S-adenosylhomocysteine (SAH), the by-product and a potent inhibitor of methyltransferases activity.
Pedro Vizán, Luciano Di Croce, Luciano Di Croce, Luciano Di Croce, Sergi Aranda   +4 more
doaj   +2 more sources

Multi-omics characterization identifies AHCY as a prognostic biomarker driving immunometabolic reprogramming in bladder cancer [PDF]

Translational Oncology
Introduction: Bladder cancer (BLCA) is a heterogeneous malignancy with poor prognosis and limited biomarkers for risk stratification and therapy guidance.
Qiao Peng, Mengmei Zhang, Shuyu Zhao, Yadong Guo, Minjue Shan, Baimei Su, Shiyu Mao, Donghui Shi, Ziyou Lin   +8 more
doaj   +2 more sources

SAM transmethylation pathway and adenosine recycling to ATP are essential for systemic regulation and immune response [PDF]

eLife
During parasitoid wasp infection, activated immune cells of Drosophila melanogaster larvae release adenosine to conserve nutrients for immune response.
Pavla Nedbalová, Nikola Kaislerova, Lenka Chodakova, Martin Moos, Tomáš Doležal   +4 more
doaj   +2 more sources

The mechanism of action of S-adenosylhomocysteinase.

Journal of Biological Chemistry, 1979
S-Adenosylhomocysteinase catalyzes the reversible hydrolysis of S-adenosyl-L-homocysteine (AdoHcy) to adenosine and L-homocysteine without added cofactors. A mechanism is proposed which involves oxidation of the 3'-hydroxyl group of AdoHcy by enzyme-bound NAD+.
R H Abeles
exaly   +3 more sources

Computer-assisted screening of mycobacterial growth inhibitors: Exclusion of frequent hitters with the assistance of the multiple target screening method

International Journal of Mycobacteriology, 2021
Background: The emergence of frequent hitters (FHs) remains a challenge in drug discovery. We have previously used in silico structure-based drug screening (SBDS) to identify antimycobacterial candidates.
Kohei Kuriki, Junichi Taira, Masato Kuroki, Hiroshi Sakamoto, Shunsuke Aoki   +4 more
doaj   +1 more source