Results 71 to 80 of about 3,470 (173)

Increased tumor necrosis factor alpha-converting enzyme activity induces insulin resistance and hepatosteatosis in mice [PDF]

, 2010
Tumor necrosis factor alpha-converting enzyme (TACE, also known as ADAM17) was recently involved in the pathogenesis of insulin resistance. We observed that TACE activity was significantly higher in livers of mice fed a high-fat diet (HFD) for 1 month ...
Cavalera, M, Fabrizi, M, Federici, M, Fiorentino, L, Khokha, R, Lauro, R, Marzano, V, Menghini, R, Menini, S, Pugliese, G, Ronci, M, Urbani, A, Vivanti, A   +12 more
core   +1 more source

Optimization of ultracentrifugation‐based method to enhance the purity and proteomic profiling depth of plasma‐derived extracellular vesicles and particles

Journal of Extracellular Biology, Volume 3, Issue 7, July 2024.
Abstract Circulating extracellular vesicles and particles (EVPs) are being investigated as potential biomarkers for early cancer detection, prognosis, and disease monitoring. However, the suboptimal purity of EVPs isolated from peripheral blood plasma has posed a challenge of in‐depth analysis of the EVP proteome. Here, we compared the effectiveness of
Zurong Wan, Jinghua Gu, Uthra Balaji, Linda Bojmar, Henrik Molina, Søren Heissel, Alexandra E. Pagano, Christopher Peralta, Lee Shaashua, Dorina Ismailgeci, Hope K. Narozniak, Yi Song, William R. Jarnagin, David P. Kelsen, Jaqueline Bromberg, Virginia Pascual, Haiying Zhang   +16 more
wiley   +1 more source

Proteomic Insights into Seminal Plasma and Spermatozoa Proteins of Small-Spotted Catsharks, Scyliorhinus canicula: Implications for Reproductive Conservation in Aquariums

Animals
In the ex situ conservation of chondrichthyan species, successful reproduction in aquaria is essential. However, these species often exhibit reduced reproductive success under human care.
Marta Muñoz-Baquero, Laura Lorenzo-Rebenaque, Ximo García-Domínguez, Jesús Valdés-Hernández, Daniel García-Párraga, Clara Marin, Francisco Alberto García-Vázquez, Francisco Marco-Jiménez   +7 more
doaj   +1 more source

Genome-wide transcription start site profiling in biofilm-grown Burkholderia cenocepacia J2315 [PDF]

, 2015
Background: Burkholderia cenocepacia is a soil-dwelling Gram-negative Betaproteobacterium with an important role as opportunistic pathogen in humans. Infections with B.
Coenye, Tom, Deforce, Dieter, Förstner, Konrad, Sass, Andrea, Van Acker, Heleen, Van Nieuwerburgh, Filip, Vogel, Jörg   +6 more
core   +2 more sources

Comparative proteomics of a versatile, marine, iron‐oxidizing chemolithoautotroph

Environmental Microbiology, Volume 26, Issue 6, June 2024.
In this study, we identified proteins that were upregulated under iron‐oxidizing conditions. Notably, we highlight a periplasmic di‐heme cytochrome c that is associated with a putative redox complex spanning the inner membrane, periplasm, outer membrane, and extracellular space.
Roman A. Barco, N. Merino, B. Lam, B. Budnik, M. Kaplan, F. Wu, J. P. Amend, K. H. Nealson, D. Emerson   +8 more
wiley   +1 more source

Analysis of barley leaf epidermis and extrahaustorial proteomes during powdery mildew infection reveals that the PR5 thaumatin-like protein TLP5 is required for susceptibility towards Blumeria graminis f. sp. hordei [PDF]

, 2019
Powdery mildews are biotrophic pathogens causing fungal diseases in many economically important crops, including cereals, which are affected by Blumeria graminis.
Aguilar, Ahmed, Ahmed, Bacete, Balakireva, Bindschedler, Bindschedler, Bindschedler, Bindschedler, Both, Both, Bourras, Bozkurt, Breen, Büschges, Caillaud, Chowdhury, Chowdhury, Chowdhury, Coaker, Daudi, Dean, Delprato, Denancé, Dinç, Ellinger, Faulkner, Finni, Frantzeskakis, Gjetting, Godfrey, Gokce, González, Guo, Guo, Howell, Jelenska, Kim, Klemptner, Kong, Kuhn, Kunoh, Kwaaitaal, Li, Liu, Lu, Lu, Lundgren, Mascher, Micali, Miyakawa, Mukhtar, Nowara, Osmond, Park, Parker, Pedersen, Pennington, Pfaffl, Pliego, Pratt, Reimand, Roberts, Rossard, Scheler, Shen, Singh, Spanu, Sun, Sun, Szabo, Takahashi, Takamatsu, Tian, Tufan, van Loon, Vigers, Weßling, Xia, Yadeta, Zhang, Zhang, Zhao, Zierold   +83 more
core   +1 more source

Domestication has altered gene expression and secondary metabolites in pea seed coat

The Plant Journal, Volume 118, Issue 6, Page 2269-2295, June 2024.
Significance Statement This work provides the first comprehensive gene expression, proteomic and metabolomic profiling of pea seed coat development. The comparison of wild and cultivated pea genotypes allowed analysis in relation to seed development, dormancy, and domestication.
Barbora Klčová, Jana Balarynová, Oldřich Trněný, Petra Krejčí, Monika Zajacová Cechová, Tatiana Leonova, Daria Gorbach, Nadezhda Frolova, Elana Kysil, Anastasia Orlova, Сhristian Ihling, Andrej Frolov, Petr Bednář, Petr Smýkal   +13 more
wiley   +1 more source

Secretoma de Beauveria bassiana relacionado à infecção no carrapato bovino Rhipicephalus microplus [PDF]

, 2016
O controle biológico é considerado uma ferramenta natural e alternativa ecológica para superar os problemas causados pela utilização de métodos químicos no controle de pragas.
Klein, Lisete Aparecida Silva
core  

Acid Sphingomyelinase Regulates the Localization and Trafficking of Palmitoylated Proteins [PDF]

, 2019
In human, loss of Acid Sphingomeylinase (ASM/SMPD1) causes Niemann-Pick Disease, type A. ASM hydrolyzes sphingomyelins to produce ceramides but protein targets of ASM remain largely unclear. ...
Kim, Yongsoon, Lee, Chia-Fang, Li, Wenjing, Sun, Hong, Xiong, Xiahui, Yu, Jiekai, Zhang, Hul, Zhu, Linyu   +7 more
core   +2 more sources

Age-related thermal response: the cellular resilience of juveniles [PDF]

, 2015
Understanding species’ responses to environmental challenges is key to predicting future biodiversity. However, there is currently little data on how developmental stages affect responses and also whether universal gene biomarkers to environmental stress
Burns, G., Clark, M.S., Peck, L.S., Thorne, M.A.S.   +3 more
core   +1 more source