Results 141 to 150 of about 70,698 (266)

Ion Channel Dysfunction and Therapeutic Targeting in Salivary Gland Disorders

Oral Diseases, EarlyView.
ABSTRACT Objective Salivary gland hypofunction and xerostomia represent major clinical complications of radiation therapy, autoimmune disorders such as Sjögren's disease, and inherited epithelial ion transport defects. This review integrates current knowledge on ion channel dysfunction as a central mechanistic driver of salivary gland pathology and ...
Tarek Mohamed Abd El‐Aziz, Shankara N. Varadarajan, Viktor Drel, Prakash Arullampalam, Mahmoud I. Shoulkamy, Ahmed Al‐Sabi, Brij B. Singh   +6 more
wiley   +1 more source

In vitro muscle contraction: A technical review on electrical pulse stimulation in C2C12 cells

Experimental Physiology, EarlyView.
Abstract Electrical pulse stimulation (EPS) of skeletal muscle cells is increasingly used to model exercise In vitro. The murine C2C12 myotube system has become a common platform for such studies, yet wide variability in EPS protocols hampers reproducibility and cross‐study comparisons.
Mark R. C. van de Meene, Anita M. van den Hoek, Roeland Hanemaaijer, Lars Verschuren, Jelle C. B. C. de Jong   +4 more
wiley   +1 more source

ADENOVIRAL INFECTION IN SUCKLING ARABIAN FOALS

, 1970
A fatal adenoviral infection was recently recognized in suckling Arabian foals from Colorado, Kansas, Nebraska, and Wyoming. Affected foals had clinical signs of pneumonia accompanied by fever, absolute lymphopenia, and neutropenia.
JJ ENGLAND (17322049), LL STACKHOUSE (17322052), AE MCCHESNEY (17322046), JL ADCOCK (18713356), TL CHOW (17322055)   +4 more
core   +1 more source

Human‐derived cardiac‐neural microtissues reveal catecholaminergic polymorphic ventricular tachycardia is also a disease of the sympathetic neuron

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic diagram illustrating the proposed pathway in which regulatory defects might occur in sympathetic neurons derived from hiPSC in catecholaminergic polymorphic ventricular tachycardia (CPVT). Specifically, enhanced calcium transients appeared to derive from three sources: enhanced membrane excitability (due to loss of ...
Ni Li, Chenchen Zhang, Mengying Xu, YoonYoung Choi, Davi Sidarta‐Oliveira, Ruirui Dong, Xinyu Hu, Enrique M. Toledo, Cesar A. Prada‐Medina, Finbar Argus, Kun Liu, Mingyu Li, Linna Zhou, Hagan Bayley, Corey Smith, Chris Denning, Ana I. Domingos, Guoliang Hao, Dan Li, David J. Paterson   +19 more
wiley   +1 more source

A 13-Year Retrospective Study of Disease Patterns of Adenoviral Keratoconjunctivitis at a Tertiary Hospital in Switzerland (2012-2025). [PDF]

Microorganisms
Jacobi M, Bajka A, Al Karam M, Barthelmes D, Voellmy I, Huber M, Said S, Blaser F.   +7 more
europepmc   +1 more source

Comparison of Wildtype and Recombinant Adeno‐Associated Virus (AAV) Production Reveals Distinct Productivity and Content Ratio Profiles

Biotechnology Journal, Volume 21, Issue 11, November 2026.
Graphical Abstract and Lay Summary Wildtype and recombinant adeno‐associated virus production are compared across infection, transfection, and hybrid systems in suspension HEK293 cells. Wildtype infection achieves markedly higher vector genome titers and content ratios than triple transfection, and adenoviral helper input governs both packaging ...
Sofia Alfieri, Kelvin H. Lee
wiley   +1 more source

Porcine Adenovirus-Based Viral Vectors for Swine Vaccines: A Scoping Review and Future Perspectives. [PDF]

Animals (Basel)
Sthitmatee N, Suanpat K, Sington Y, Muenthaisong A, Sangkakam K, Nambooppha B, Rittipornlertrak A, Apinda N, Koonyosying P, Varinrak T, Kreausukon K.   +10 more
europepmc   +1 more source

High Cell Density Cultivation of HEK293 Cells Using a 2L Membrane‐Stirred Bioreactor

Biotechnology and Bioengineering, Volume 123, Issue 11, Page 3165-3174, November 2026.
ABSTRACT The use of perfusion systems for the continuous cultivation of animal cells at high cell density (HCD) for the production of recombinant proteins, viruses, and viral vectors has many advantages. Besides an enhancement of volumetric productivity and high cell viability, the product quality can be improved through a steady‐state environment ...
Lennart Jacobtorweihe, Yasemin van Heuvel, Kathrina Scheiermann, Patrick Bongartz, Yvonne Genzel, Udo Reichl   +5 more
wiley   +1 more source

Adaptive Immunity in Marsupials

Journal of Experimental Zoology Part A: Ecological and Integrative Physiology, Volume 345, Issue 9, Page 913-932, November 2026.
Comparison of the marsupial and eutherian adaptive immune systems. ABSTRACT Marsupials diverged from eutherian mammals 125–160 million years ago. Although evolutionarily distinct, both groups of mammals can produce complex adaptive immune responses to antigens with several key differences.
Cassandra L. Jol, Hayley J. Stannard, Julie M. Old   +2 more
wiley   +1 more source

Host Barriers to In Vivo HSC Gene Therapy with Helper-Dependent Adenovirus Vectors. [PDF]

Viruses
Anderson AK, Lieber A, Li C.
europepmc   +1 more source