Viruses, 2021 Several human adenoviral (Ad) vectors have been developed for vaccine delivery owing to their numerous advantages, including the feasibility of different vector designs, the robustness of elicited immune responses, safety, and scalability.
Marwa Alhashimi +3 more
doaj +3 more sources
Prolonged effects of adenoviral vector priming on T-cell cytokine production in heterologous adenoviral vector/mRNA COVID-19 vaccination regimens [PDF]
Scientific ReportsmRNA and adenoviral vector vaccine platforms were used for the primary series of COVID-19 vaccines in many countries. However, the distinct immunogenic properties on these platforms remain less understood.
Masanori Isogawa +12 more
doaj +2 more sources
Developing the next-generation of adenoviral vector vaccines [PDF]
Human Vaccines & ImmunotherapeuticsThe COVID-19 pandemic saw the first extensive use of adenoviral vector vaccines, with over 3 billion doses produced during the first year of the pandemic alone and an estimated 6 million lives saved.
Alexander T. Sampson +4 more
doaj +2 more sources
Adenoviral Vector-Based Vaccine Platforms for Developing the Next Generation of Influenza Vaccines
Vaccines, 2020 Ever since the discovery of vaccines, many deadly diseases have been contained worldwide, ultimately culminating in the eradication of smallpox and polio, which represented significant medical achievements in human health.
Ekramy E. Sayedahmed +4 more
doaj +3 more sources
Intranasal Adenoviral Vector Vaccination Induces Durable Antibody and T Cell Responses in the Respiratory Tract [PDF]
VaccinesBackground/Objectives: Respiratory pathogens such as influenza virus and SARS-CoV-2 pose major threats to global public health. Current vaccines provide limited mucosal protection against respiratory infection, while vaccine-induced immunity can wane ...
Woochan Lee +3 more
doaj +2 more sources
Adenoviral Vector-Based Vaccine Expressing Hemagglutinin Stem Region with Autophagy-Inducing Peptide Confers Cross-Protection Against Group 1 and 2 Influenza A Viruses [PDF]
VaccinesBackground/Objectives: An effective universal influenza vaccine is urgently needed to overcome the limitations of current seasonal influenza vaccines, which are ineffective against mismatched strains and unable to protect against pandemic influenza ...
Wen-Chien Wang +7 more
doaj +2 more sources
Enhancement of mucosal innate and adaptive immunity following intranasal immunization of mice with a bovine adenoviral vector [PDF]
Frontiers in Immunology, 2023 IntroductionNonhuman adenoviral (AdV) gene delivery platforms have significant value due to their ability to elude preexisting AdV vector immunity in most individuals.
Ekramy E. Sayedahmed +5 more
doaj +2 more sources
Adenoviral vector oropharyngeal spray immunization elicits mucosal immunity and protects against heterologous SARS-CoV-2 infection [PDF]
npj VaccinesMucosal immunity may be required to prevent the ongoing transmission of SARS-CoV-2 emerging variants of concern. To define the most efficient way to induce protective mucosal immunity, we compared three different forms of mucosal antigen exposure in mRNA
Gerrit Koopman +14 more
doaj +2 more sources
Pandemic-response adenoviral vector and RNA vaccine manufacturing [PDF]
npj Vaccines, 2022 Rapid global COVID-19 pandemic response by mass vaccination is currently limited by the rate of vaccine manufacturing. This study presents a techno-economic feasibility assessment and comparison of three vaccine production platform technologies deployed ...
Zoltán Kis +6 more
doaj +2 more sources
Significance of Preexisting Vector Immunity and Activation of Innate Responses for Adenoviral Vector-Based Therapy [PDF]
Viruses, 2022 Suresh K Mittal +2 more
exaly +2 more sources