Results 21 to 30 of about 39,421 (210)
Journal of Experimental & Clinical Cancer Research, 2010 Background Non-small cell lung cancer (NSCLC) is the leading cause of cancer related mortality, any improvements in therapeutic strategies are urgently required.
Ren Peng-Kang +7 more
doaj +1 more source
Journal of Medical Case Reports, 2022 Background Incidence of myocarditis following messenger RNA coronavirus disease 2019 vaccination has been widely described, but this clinical scenario after adenoviral vector coronavirus disease 2019 vaccination has only been rarely reported. In addition,
Apichai Marsukjai +5 more
doaj +1 more source
Hepatology, EarlyView., 2022 Mesenchymal stem cells subset, educated by TNF‐α, are involved to generate inflammatory microenvironment and promote hepatocarcinogenesis Abstract Background and Aims Increasing evidence suggests that mesenchymal stem cells (MSCs) home to injured local tissues and the tumor microenvironment in the liver.
Chen Zong +9 more
wiley +1 more source
Ocular localization and transduction by adenoviral vectors are serotype-dependent and can be modified by inclusion of RGD fiber modifications. [PDF]
PLoS ONE, 2014 To evaluate localization and transgene expression from adenoviral vector of serotypes 5, 35, and 28, ± an RGD motif in the fiber following intravitreal or subretinal administration.Ocular transduction by adenoviral vector serotypes ± RGD was studied in ...
Kazuhiro Ueyama +7 more
doaj +1 more source
Helper-dependent adenoviral vectors [PDF]
Journal of Genetic Syndromes & Gene Therapy, 2010 Helper-dependent adenoviral vectors are devoid of all viral coding sequences, possess a large cloning capacity, and can efficiently transduce a wide variety of cell types from various species independent of the cell cycle to mediate long-term transgene expression without chronic toxicity.
Nicola Brunetti-Pierri, Philip Ng
openaire +3 more sources
Sheep lung segmental delivery strategy demonstrates adenovirus priming of local lung responses to bacterial LPS and the role of elafin as a response modulator. [PDF]
PLoS ONE, 2014 Viral lung infections increase susceptibility to subsequent bacterial infection. We questioned whether local lung administration of recombinant adenoviral vectors in the sheep would alter the susceptibility of the lung to subsequent challenge with ...
Thomas I Brown +4 more
doaj +1 more source
Molecular Therapy: Nucleic Acids, 2016 Helper-dependent adenoviral vectors mediate high efficiency gene editing in induced pluripotent stem cells without needing a designer nuclease thereby avoiding off-target cleavage.
Donna J Palmer +6 more
doaj +1 more source
PLoS ONE, 2020 Adenoviruses cause upper respiratory infections, conjunctivitis, keratitis, and gastrointestinal illness. These can be fatal in immunocompromised individuals.
Alice Liu +4 more
doaj +1 more source
JBMR Plus, 2021 Bromodomain (BRD) proteins are histone code interpreters that recognize acetylated lysines and link the dynamic state of chromatin with the transcriptional machinery.
Christopher R Paradise +6 more
doaj +1 more source
Adenoviral Vectors in Gene Therapy [PDF]
Klinicka onkologie, 2015 This review is focused on gene therapy, especially adenovirus vectors and their relationship with the immune system response. Adenovirus vectors belong to the most used gene delivery vehicles in gene therapy, study of gene expression or immunotherapy. One of the most important questions concerning their use is their influence on organism in vivo. Study
M, Pjechová +4 more
openaire +2 more sources