Results 11 to 20 of about 39,421 (210)
Reporting adverse events of COVID-19 vaccines: The case of Bulgaria.
PLoS ONE, 2022 As a member state of the European Union, where vaccines against COVID-19 are available and affordable, Bulgaria reports the lowest immunization coverage and the most pronounced vaccine distrust. The present study aimed to assess the self-reported adverse
Vanya Rangelova +3 more
doaj +2 more sources
Pre-existing vector immunity does not prevent replication deficient adenovirus from inducing efficient CD8 T-cell memory and recall responses. [PDF]
PLoS ONE, 2012 Adenoviral vectors have shown a great potential for vaccine development due to their inherent ability to induce potent and protective CD8 T-cell responses.
Maria Abildgaard Steffensen +5 more
doaj +1 more source
Clinical & Translational Immunology, 2021 Since the development of the first vaccine against smallpox over two centuries ago, vaccination strategies have been at the forefront of significantly impacting the incidences of infectious diseases globally. However, the increase in the human population,
Ahmed Elkashif +4 more
doaj +1 more source
Journal of International Medical Research, 2020 Objectives Construction of adenoviral vectors can be complicated and time-consuming. The aim of this study was to construct an adenoviral vector expressing human bone morphogenetic protein 2 (BMP-2).
Liangquan Peng +8 more
doaj +1 more source
Adenoviral vector vaccine platforms in the SARS-CoV-2 pandemic
npj Vaccines, 2021 Adenoviral vectors have been explored as vaccine agents for a range of infectious diseases, and their ability to induce a potent and balanced immune response made them logical candidates to apply to the COVID-19 pandemic.
Samir Andrade Mendonça +3 more
doaj +1 more source
A Confirmatory, Dual Center Nonhuman Primate Study on the Efficacy of Novel Oropharyngeal Spray Immunization With an Adenoviral Vector Vaccine Against RSV-Important Lessons Learned. [PDF]
J Med PrimatolABSTRACT Background In a randomized, blinded, dual center study across two European primate research facilities, we evaluated the immunogenicity and protective efficacy of a DNA prime—oropharyngeal adenoviral boost vaccination strategy against respiratory syncytial virus (RSV).
Tenbusch M +15 more
europepmc +2 more sources
Efficient Gene Transfer and Expression in Islets by an Adenoviral Vector that Lacks All Viral Genes
Cell Transplantation, 1999 Although adenoviral vector-mediated gene transfer has significant potential for gene therapy, host immune responses to virally expressed proteins and small insert capacity may limit its clinical application.
Zhiguang Guo +7 more
doaj +1 more source
Vaccine induced thrombotic thrombocytopenia: The shady chapter of a success story
Metabolism Open, 2021 The recognition of the rare but serious and potentially lethal complication of vaccine induced thrombotic thrombocytopenia (VITT) raised concerns regarding the safety of COVID-19 vaccines and led to the reconsideration of vaccination strategies in many ...
Dimitrios Tsilingiris +3 more
doaj +1 more source
Progress in Adenoviral Capsid-Display Vaccines
Biomedicines, 2018 Adenoviral vectored vaccines against infectious diseases are currently in clinical trials due to their capacity to induce potent antigen-specific B- and T-cell immune responses. Heterologous prime-boost vaccination with adenoviral vector and, for example,
Marija Vujadinovic, Jort Vellinga
doaj +1 more source
Hepatology, EarlyView., 2022 Physiological activation of myeloid p38 controls macrophage IL‐12 production and crosstalk to the liver by modulating hepatic FGF21, and subsequently, brown adipose tissue thermogenesis during obesity Abstract Obesity features excessive fat accumulation in several body tissues and induces a state of chronic low‐grade inflammation that contributes to ...
María Crespo +14 more
wiley +1 more source