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Bovine Adenovirus 3-Based Viral Vectors for Veterinary Vaccine Development: Progress, Limitations, and Future Directions [PDF]

Veterinary Sciences
Bovine adenovirus (BAdV)-based vectors, particularly those derived from bovine adenovirus 3 (BAdV-3), are emerging non-human adenoviral platforms for veterinary vaccine development.
Nattawooti Sthitmatee, Thanya Varinrak, Khwanchai Kreausukon   +2 more
doaj   +2 more sources

Adenoviral Vector-Based Vaccine Platforms for Developing the Next Generation of Influenza Vaccines

Vaccines, 2020
Ever since the discovery of vaccines, many deadly diseases have been contained worldwide, ultimately culminating in the eradication of smallpox and polio, which represented significant medical achievements in human health.
Ekramy E. Sayedahmed, Ahmed Elkashif, Marwa Alhashimi, Suryaprakash Sambhara, Suresh K. Mittal   +4 more
doaj   +3 more sources

Nonhuman Adenoviral Vector-Based Platforms and Their Utility in Designing Next Generation of Vaccines for Infectious Diseases

Viruses, 2021
Several human adenoviral (Ad) vectors have been developed for vaccine delivery owing to their numerous advantages, including the feasibility of different vector designs, the robustness of elicited immune responses, safety, and scalability.
Marwa Alhashimi, Ahmed Elkashif, Ekramy E. Sayedahmed, Suresh K. Mittal   +3 more
doaj   +3 more sources

A Bovine Adenoviral Vector-Based H5N1 Influenza -Vaccine Provides Enhanced Immunogenicity and Protection at a Significantly Low Dose

Molecular Therapy: Methods & Clinical Development, 2018
Several human and nonhuman adenovirus (AdV) vectors including bovine AdV type 3 (BAdV-3) were developed as gene delivery vectors to supplement and/or elude human AdV (HAdV)-specific neutralizing antibodies (vector immunity). Here we evaluated the vaccine
Ekramy E. Sayedahmed, Ahmed O. Hassan, Rashmi Kumari, Weiping Cao, Shivaprakash Gangappa, Ian York, Suryaprakash Sambhara, Suresh K. Mittal   +7 more
doaj   +3 more sources

Adenoviral Vectors Meet Gene Editing: A Rising Partnership for the Genomic Engineering of Human Stem Cells and Their Progeny

Cells, 2020
Gene editing permits changing specific DNA sequences within the vast genomes of human cells. Stem cells are particularly attractive targets for gene editing interventions as their self-renewal and differentiation capabilities consent studying cellular ...
Francesca Tasca, Qian Wang, Manuel A.F.V. Gonçalves   +2 more
doaj   +3 more sources

Significance of Preexisting Vector Immunity and Activation of Innate Responses for Adenoviral Vector-Based Therapy

Viruses, 2022
An adenoviral (AdV)-based vector system is a promising platform for vaccine development and gene therapy applications. Administration of an AdV vector elicits robust innate immunity, leading to the development of humoral and cellular immune responses ...
Wen-Chien Wang, Ekramy E. Sayedahmed, Suresh K. Mittal   +2 more
doaj   +3 more sources

Vaccine-Induced Immune Thrombotic Thrombocytopenia (VITT): An Immunopathogenic Model of Dysregulated Vaccine-Triggered Immunity [PDF]

Vaccines
Background/Objectives: Vaccine-induced immune thrombotic thrombocytopenia (VITT) is a rare but severe immune-mediated adverse event associated with adenoviral vector-based SARS-CoV-2 vaccines.
Carmine Siniscalchi, Manuela Basaglia, Antonella Tufano, Egidio Imbalzano, Pierpaolo Di Micco   +4 more
doaj   +2 more sources

Adenoviral vector‐based platforms for developing effective vaccines to combat respiratory viral infections

Clinical & Translational Immunology, 2021
Since the development of the first vaccine against smallpox over two centuries ago, vaccination strategies have been at the forefront of significantly impacting the incidences of infectious diseases globally. However, the increase in the human population,
Ahmed Elkashif, Marwa Alhashimi, Ekramy E Sayedahmed, Suryaprakash Sambhara, Suresh K Mittal   +4 more
doaj   +1 more source

Pre-existing vector immunity does not prevent replication deficient adenovirus from inducing efficient CD8 T-cell memory and recall responses. [PDF]

PLoS ONE, 2012
Adenoviral vectors have shown a great potential for vaccine development due to their inherent ability to induce potent and protective CD8 T-cell responses.
Maria Abildgaard Steffensen, Benjamin Anderschou Holbech Jensen, Peter Johannes Holst, Maria Rosaria Bassi, Jan Pravsgaard Christensen, Allan Randrup Thomsen   +5 more
doaj   +1 more source

Construction and characterization of an adenoviral vector encoding human bone morphogenetic protein-2

Journal of International Medical Research, 2020
Objectives Construction of adenoviral vectors can be complicated and time-consuming. The aim of this study was to construct an adenoviral vector expressing human bone morphogenetic protein 2 (BMP-2).
Liangquan Peng, Kang Chen, Weimin Zhu, Wei Lu, Jian Xu, Yong Huang, Shengzheng Kuai, Zhenhan Deng, Daping Wang   +8 more
doaj   +1 more source