Results 11 to 20 of about 35,510 (163)

Adenoviral vector vaccine platforms in the SARS-CoV-2 pandemic

npj Vaccines, 2021
Adenoviral vectors have been explored as vaccine agents for a range of infectious diseases, and their ability to induce a potent and balanced immune response made them logical candidates to apply to the COVID-19 pandemic.
Samir Andrade Mendonça, Reka Lorincz, Paul Boucher, David T. Curiel   +3 more
doaj   +1 more source

Enhancement of mucosal innate and adaptive immunity following intranasal immunization of mice with a bovine adenoviral vector

Frontiers in Immunology, 2023
IntroductionNonhuman adenoviral (AdV) gene delivery platforms have significant value due to their ability to elude preexisting AdV vector immunity in most individuals.
Ekramy E. Sayedahmed, Nelly O. Elshafie, GuangJun Zhang, Sulma I. Mohammed, Suryaprakash Sambhara, Suresh K. Mittal   +5 more
doaj   +1 more source

Construction of recombinant adenovirus-5 vector to prevent replication-competent adenovirus occurrence

Acta Virologica, 2023
Human adenovirus-5 (hAd5) is an important gene delivery vector, which has been widely used in various fields of biomedicine, such as gene therapy, cancer therapy, and vaccine development.
Wenbo Xie, Yifei Yuan, Bo Liu, Min Liang, Min Liang   +4 more
doaj   +1 more source

Immunological Study of Reconstructed Common Ancestral Sequence of Adenovirus Hexon Protein

Frontiers in Microbiology, 2021
Aim: To reconstruct the ancestral sequence of human adenoviral hexon protein by combining sequence variations and structural information. And to provide a candidate hexon protein for developing new adenoviral vector capable of escaping the pre-existing ...
Yingchen Wang, Zhe Zhang, Lei Shang, Hong Gao, Xiqiao Du, Xiqiao Du, Falong Li, Ya Gao, Guiyun Qi, Weiyuan Guo, Zhangyi Qu, Zhangyi Qu, Tuo Dong   +12 more
doaj   +1 more source

Potent anti-tumor activity of telomerase-dependent and HSV-TK armed oncolytic adenovirus for non-small cell lung cancer in vitro and in vivo

Journal of Experimental & Clinical Cancer Research, 2010
Background Non-small cell lung cancer (NSCLC) is the leading cause of cancer related mortality, any improvements in therapeutic strategies are urgently required.
Ren Peng-Kang, Qiu Wei, Li Hui-Ming, Wang Hui-Ping, Wei Fang, Zhang Ju-Feng, Chen Xia-Fang, Huang Qian   +7 more
doaj   +1 more source

Brd4 Inactivation Increases Adenoviral Delivery of BMP2 for Paracrine Stimulation of Osteogenic Differentiation as a Gene Therapeutic Concept to Enhance Bone Healing

JBMR Plus, 2021
Bromodomain (BRD) proteins are histone code interpreters that recognize acetylated lysines and link the dynamic state of chromatin with the transcriptional machinery.
Christopher R Paradise, Rodolfo E De La Vega, M Lizeth Galvan, Margarita E Carrasco, Roman Thaler, Andre J vanWijnen, Amel Dudakovic   +6 more
doaj   +1 more source

Construction and application of adenoviral vectors

Molecular Therapy: Nucleic Acids, 2023
Adenoviral vectors have been widely used as vaccine candidates or potential vaccine candidates against infectious diseases due to the convenience of genome manipulation, their ability to accommodate large exogenous gene fragments, easy access of ...
Hongbo Zhang, Hongdan Wang, Youcai An, Ze Chen   +3 more
doaj   +1 more source

Adenoviral delivery of the EMX2 gene suppresses growth in human gastric cancer.

PLoS ONE, 2012
BackgroundEMX2 is a human orthologue of the Drosophila empty spiracles homeobox gene that has been implicated in embryogenesis. Recent studies suggest possible involvement of EMX2 in human cancers; however, the role of EMX2 in carcinogenesis needs ...
Jie Li, Minli Mo, Zhao Chen, Zhe Chen, Qing Sheng, Hang Mu, Fang Zhang, Yi Zhang, Xiu-Yi Zhi, Hui Li, Biao He, Hai-Meng Zhou   +11 more
doaj   +1 more source

Myeloid p38 activation maintains macrophage–liver crosstalk and BAT thermogenesis through IL‐12–FGF21 axis

Hepatology, EarlyView., 2022
Physiological activation of myeloid p38 controls macrophage IL‐12 production and crosstalk to the liver by modulating hepatic FGF21, and subsequently, brown adipose tissue thermogenesis during obesity Abstract Obesity features excessive fat accumulation in several body tissues and induces a state of chronic low‐grade inflammation that contributes to ...
María Crespo, Ivana Nikolic, Alfonso Mora, Elena Rodríguez, Luis Leiva‐Vega, Aránzazu Pintor‐Chocano, Daniel Horrillo, Lourdes Hernández‐Cosido, Jorge L. Torres, Eva Novoa, Rubén Nogueiras, Gema Medina‐Gómez, Miguel Marcos, Magdalena Leiva, Guadalupe Sabio   +14 more
wiley   +1 more source

AIF1+CSF1R+ MSCs, induced by TNF‐α, act to generate an inflammatory microenvironment and promote hepatocarcinogenesis

Hepatology, EarlyView., 2022
Mesenchymal stem cells subset, educated by TNF‐α, are involved to generate inflammatory microenvironment and promote hepatocarcinogenesis Abstract Background and Aims Increasing evidence suggests that mesenchymal stem cells (MSCs) home to injured local tissues and the tumor microenvironment in the liver.
Chen Zong, Yan Meng, Fei Ye, Xue Yang, Rong Li, Jinghua Jiang, Qiudong Zhao, Lu Gao, Zhipeng Han, Lixin Wei   +9 more
wiley   +1 more source