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Frontiers in Immunology, 2023 IntroductionNonhuman adenoviral (AdV) gene delivery platforms have significant value due to their ability to elude preexisting AdV vector immunity in most individuals.
Ekramy E. Sayedahmed +5 more
doaj +6 more sources
A Bovine Adenoviral Vector-Based H5N1 Influenza -Vaccine Provides Enhanced Immunogenicity and Protection at a Significantly Low Dose [PDF]
Molecular Therapy: Methods & Clinical Development, 2018 Several human and nonhuman adenovirus (AdV) vectors including bovine AdV type 3 (BAdV-3) were developed as gene delivery vectors to supplement and/or elude human AdV (HAdV)-specific neutralizing antibodies (vector immunity). Here we evaluated the vaccine
Ekramy E. Sayedahmed +7 more
doaj +6 more sources
Bovine Adenoviral Vector-Based Platform for Vaccine Development
VaccinesAdenoviral (AdV) vector-based vaccines employing the human AdV (HAdV) and chimpanzee AdV (ChAdV) vector platforms played a crucial role in combating the COVID-19 pandemic.
Ekramy E. Sayedahmed +3 more
doaj +6 more sources
Evaluation of Innate Immunity and Vector Toxicity Following Inoculation of Bovine, Porcine or Human Adenoviral Vectors in a Mouse Model [PDF]
Virus Research, 2010 Nonhuman adenovirus (Ad) vectors derived from bovine Ad serotype 3 (BAd3) or porcine Ad serotype 3 (PAd3) can circumvent pre-existing immunity against human Ad (HAd). We have previously reported differential transduction of human and nonhuman cells by these Ad vectors, and their distinct receptor usage and biodistribution.
Suresh K Mittal +2 more
exaly +4 more sources
Persistence and the State of Bovine and Porcine Adenoviral Vector Genomes in Human and Nonhuman Cell Lines [PDF]
Virus Research, 2011 The state of vector genome in transduced cells influences the duration of transgene expression and can be a safety concern if it gets integrated randomly into the host genome. Although human adenovirus (Ad) serotype 5 (HAd5) mainly persists in a linear episomal form, information regarding the state of bovine Ad serotype 3 (BAd3) and porcine Ad serotype
Suresh K Mittal, Dinesh S Bangari
exaly +4 more sources
PathogensBovine coronavirus (BCoV) is distributed globally and mainly causes different clinical manifestations: enteric diarrhea in calves, winter dysentery in adults, and respiratory symptoms in cattle of all ages.
Annamaria Pratelli +8 more
doaj +5 more sources
Virology, 2009 Nonhuman adenoviruses including bovine adenovirus serotype 3 (BAd3) and porcine adenovirus serotype 3 (PAd3) can circumvent pre-existing immunity against human adenovirus serotype 5 (HAd5) and are being developed as alternative vectors for gene delivery.
Suresh K Mittal +2 more
exaly +4 more sources
VaccinesBackground/Objectives: An effective universal influenza vaccine is urgently needed to overcome the limitations of current seasonal influenza vaccines, which are ineffective against mismatched strains and unable to protect against pandemic influenza ...
Wen-Chien Wang +7 more
doaj +4 more sources
Molecular Therapy - Nucleic AcidsCurrent seasonal influenza vaccines offer strain-specific protection and, thus, are less effective against mismatched strains. A broadly protective influenza vaccine is desirable to provide comprehensive protection against a wide range of influenza viruses for seasonal and pandemic influenza preparedness. Here, we evaluated the vaccine candidates based
Suresh K Mittal +2 more
exaly +4 more sources
Molecular Therapy, 2008 Because of the high prevalence of adenovirus (Ad) infections in humans, it is believed that pre-existing Ad-neutralizing antibodies (vector immunity) may negatively impact the immune response to vaccine antigens when delivered by human Ad (HAd) vectors.
Singh, Neetu +3 more
openaire +3 more sources