Results 11 to 20 of about 1,298,087 (175)

Intranasal adenoviral neuraminidase vaccine induces local and systemic immunity and homosubtypic protection against influenza A viruses [PDF]

Frontiers in Immunology
IntroductionThe rapid antigenic drift of influenza A hemagglutinin (HA) limits the effectiveness of current HA-focused vaccines. To address this challenge, we evaluated recombinant human (HAd) and bovine (BAd) adenoviral vectors expressing neuraminidase (
Wen-Chien Wang, Weiping Cao, Amrita Kumar, Wadzanai P. Mboko, Ram Kamal, Ekramy E. Sayedahmed, Suresh K. Mittal   +6 more
doaj   +3 more sources

Dual-route H5N1 vaccination induces systemic and mucosal immunity in murine and bovine models [PDF]

npj Vaccines
Highly pathogenic H5N1 avian influenza (clade 2.3.4.4b) has spread widely among dairy cattle herds since early 2024, causing major economic losses. This zoonotic event emphasizes the urgent need for H5 vaccines eliciting strong, durable, cross-reactive ...
Joshua Wiggins, Adthakorn Madapong, Eric A. Weaver   +2 more
doaj   +4 more sources

Bovine Adenovirus 3-Based Viral Vectors for Veterinary Vaccine Development: Progress, Limitations, and Future Directions [PDF]

Veterinary Sciences
Bovine adenovirus (BAdV)-based vectors, particularly those derived from bovine adenovirus 3 (BAdV-3), are emerging non-human adenoviral platforms for veterinary vaccine development.
Nattawooti Sthitmatee, Thanya Varinrak, Khwanchai Kreausukon   +2 more
doaj   +2 more sources

Ad26.RSV.preF completely protects calves from severe respiratory disease induced by bovine RSV challenge

npj Vaccines
Vaccination with Ad26.RSV.preF, an Adenoviral serotype 26 vector encoding RSV F protein stabilized in its prefusion conformation, has previously shown to be immunogenic and protective in RSV seropositive adults and immunogenic in seropositive infants ...
Leslie van der Fits, Rineke de Jong, Karin Dijkman, Marjolein Heemskerk-van der Meer, Lisanne Tettero, Judith Bonsing, Sophie van Oort, Jan Serroyen, Marianke van Schie, Norbert Stockhofe-Zurwieden, Benoit Callendret, Roland Zahn   +11 more
doaj   +2 more sources

A Multiepitope Intranasal Adenoviral Vaccine Induces Robust Mucosal Immunity and Protection against SARS‑CoV‑2 [PDF]

Journal of Nanobiotechnology
Background Vaccination has been central to mitigating the COVID-19 pandemic; however, the continual emergence of SARS-CoV-2 variants of concern (VOCs) has reduced the effectiveness of current intramuscular vaccines that primarily target the Spike (S ...
Ahmed Elkashif, Muralimanohara S. T. Murala, Carolyn M. Lee, Raksha Suresh, Marwa Alhashimi, Wen-Chien Wang, Vivek Gairola, Andrea Pires dos Santos, Patricia A. Boley, Jennifer Schrock, Scott Kenney, Ekramy E. Sayedahmed, Gourapura J. Renukaradhya, Suresh K. Mittal   +13 more
doaj   +2 more sources

An Adenoviral-Vectored Tp0326 Vaccine Elicits Robust Functional Antibodies to Prevent Treponema pallidum Dissemination in a Rabbit Model. [PDF]

Adv Sci (Weinh)
Vaccination promotes cellular infiltration into primary lesions and effectively inhibits T. pallidum dissemination to distal organs. Notably, transfer of lesion tissue from immunized animals fails to establish infection in naive recipients, confirming specific protective immunity.
Jiang Y, Li X, Huang L, Zhang X, Ke W.
europepmc   +2 more sources

A Confirmatory, Dual Center Nonhuman Primate Study on the Efficacy of Novel Oropharyngeal Spray Immunization With an Adenoviral Vector Vaccine Against RSV-Important Lessons Learned. [PDF]

J Med Primatol
ABSTRACT Background In a randomized, blinded, dual center study across two European primate research facilities, we evaluated the immunogenicity and protective efficacy of a DNA prime—oropharyngeal adenoviral boost vaccination strategy against respiratory syncytial virus (RSV).
Tenbusch M, Koopman G, Mooij P, Roshani B, Irrgang P, Lapuente D, Kondova I, Bogers WM, Remarque EJ, Vestweber R, Merida Ruiz SA, Krüger N, Meyer S, Gefeller O, Stahl-Hennig C, Überla K.   +15 more
europepmc   +2 more sources

Characterisation of a new molecule based on two E2 sequences from bovine viral diarrhoea-mucosal disease virus fused to the human immunoglobulin Fc fragment

Journal of Veterinary Research, 2021
Proper conformational arrangement of the E2 molecules of bovine viral diarrhoea-mucosal disease virus (BVD-MDV) is crucial to obtain an effective recombinant vaccine candidate against the disease.
González Pose Alaín, Montesino Seguí Raquel, Maura Pérez Rafael, Hugues Salazar Florence, Cabezas Ávila Ignacio, Altamirano Gómez Claudia, Sánchez Ramos Oliberto, Roberto Toledo Jorge   +7 more
doaj   +1 more source

Myeloid p38 activation maintains macrophage–liver crosstalk and BAT thermogenesis through IL‐12–FGF21 axis

Hepatology, EarlyView., 2022
Physiological activation of myeloid p38 controls macrophage IL‐12 production and crosstalk to the liver by modulating hepatic FGF21, and subsequently, brown adipose tissue thermogenesis during obesity Abstract Obesity features excessive fat accumulation in several body tissues and induces a state of chronic low‐grade inflammation that contributes to ...
María Crespo, Ivana Nikolic, Alfonso Mora, Elena Rodríguez, Luis Leiva‐Vega, Aránzazu Pintor‐Chocano, Daniel Horrillo, Lourdes Hernández‐Cosido, Jorge L. Torres, Eva Novoa, Rubén Nogueiras, Gema Medina‐Gómez, Miguel Marcos, Magdalena Leiva, Guadalupe Sabio   +14 more
wiley   +1 more source

Novel method for reduction of virus load in blood plasma by sonication

European Journal of Medical Research, 2020
Background Aim of the present study is the evaluation of ultrasound as a physical method for virus inactivation in human plasma products prior to transfusion.
D. Pförringer, K. F. Braun, H. Mühlhofer, J. Schneider, A. Stemberger, E. Seifried, E. Pohlscheidt, M. Seidel, G. Edenharter, D. Duscher, R. Burgkart, A. Obermeier   +11 more
doaj   +1 more source