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Nonhuman Adenoviral Vector-Based Platforms and Their Utility in Designing Next Generation of Vaccines for Infectious Diseases [PDF]

Viruses, 2021
Several human adenoviral (Ad) vectors have been developed for vaccine delivery owing to their numerous advantages, including the feasibility of different vector designs, the robustness of elicited immune responses, safety, and scalability.
Marwa Alhashimi, Ahmed Elkashif, Ekramy E. Sayedahmed, Suresh K. Mittal   +3 more
doaj   +8 more sources

Circumventing Antivector Immunity: Potential Use of Nonhuman Adenoviral Vectors [PDF]

Human Gene Therapy, 2014
Adenoviruses are efficient gene delivery vectors based on their ability to transduce a wide variety of cell types and drive high-level transient transgene expression. While there have been advances in modifying human adenoviral (HAdV) vectors to increase their safety profile, there are still pitfalls that need to be further addressed.
Ramon Alemany, Iva I Podgorski
exaly   +10 more sources

Significance of Preexisting Vector Immunity and Activation of Innate Responses for Adenoviral Vector-Based Therapy

Viruses, 2022
An adenoviral (AdV)-based vector system is a promising platform for vaccine development and gene therapy applications. Administration of an AdV vector elicits robust innate immunity, leading to the development of humoral and cellular immune responses ...
Wen-Chien Wang, Ekramy E. Sayedahmed, Suresh K. Mittal   +2 more
doaj   +4 more sources

A Bovine Adenoviral Vector-Based H5N1 Influenza -Vaccine Provides Enhanced Immunogenicity and Protection at a Significantly Low Dose

Molecular Therapy: Methods & Clinical Development, 2018
Several human and nonhuman adenovirus (AdV) vectors including bovine AdV type 3 (BAdV-3) were developed as gene delivery vectors to supplement and/or elude human AdV (HAdV)-specific neutralizing antibodies (vector immunity). Here we evaluated the vaccine
Ekramy E. Sayedahmed, Ahmed O. Hassan, Rashmi Kumari, Weiping Cao, Shivaprakash Gangappa, Ian York, Suryaprakash Sambhara, Suresh K. Mittal   +7 more
doaj   +4 more sources

Bovine Adenoviral Vector-Based Platform for Vaccine Development [PDF]

Vaccines
Adenoviral (AdV) vector-based vaccines employing the human AdV (HAdV) and chimpanzee AdV (ChAdV) vector platforms played a crucial role in combating the COVID-19 pandemic.
Ekramy E. Sayedahmed, Vivek Gairola, Muralimanohara S. T. Murala, Suresh K. Mittal   +3 more
doaj   +4 more sources

Adenoviral Vector-Based Vaccine Platforms for Developing the Next Generation of Influenza Vaccines

Vaccines, 2020
Ever since the discovery of vaccines, many deadly diseases have been contained worldwide, ultimately culminating in the eradication of smallpox and polio, which represented significant medical achievements in human health.
Ekramy E. Sayedahmed, Ahmed Elkashif, Marwa Alhashimi, Suryaprakash Sambhara, Suresh K. Mittal   +4 more
doaj   +3 more sources

Adenoviral vector‐based platforms for developing effective vaccines to combat respiratory viral infections

Clinical & Translational Immunology, 2021
Since the development of the first vaccine against smallpox over two centuries ago, vaccination strategies have been at the forefront of significantly impacting the incidences of infectious diseases globally. However, the increase in the human population,
Ahmed Elkashif, Marwa Alhashimi, Ekramy E Sayedahmed, Suryaprakash Sambhara, Suresh K Mittal   +4 more
doaj   +2 more sources

Persistence and the State of Bovine and Porcine Adenoviral Vector Genomes in Human and Nonhuman Cell Lines [PDF]

Virus Research, 2011
The state of vector genome in transduced cells influences the duration of transgene expression and can be a safety concern if it gets integrated randomly into the host genome. Although human adenovirus (Ad) serotype 5 (HAd5) mainly persists in a linear episomal form, information regarding the state of bovine Ad serotype 3 (BAd3) and porcine Ad serotype
Suresh K Mittal, Dinesh S Bangari
exaly   +3 more sources

Adenoviral vector type 26 encoding Zika virus (ZIKV) M-Env antigen induces humoral and cellular immune responses and protects mice and nonhuman primates against ZIKV challenge. [PDF]

PLoS ONE, 2018
In 2015, there was a large outbreak of Zika virus (ZIKV) in Brazil. Despite its relatively mild impact on healthy adults, ZIKV infection during pregnancy has been associated with severe birth defects.
Freek Cox, Leslie van der Fits, Peter Abbink, Rafael A Larocca, Ella van Huizen, Eirikur Saeland, Janneke Verhagen, Rebecca Peterson, Jeroen Tolboom, Baerbel Kaufmann, Hanneke Schuitemaker, Dan H Barouch, Roland Zahn   +12 more
doaj   +4 more sources

Transgene Expression Up to 7 Years in Nonhuman Primates Following Hepatic Transduction With Helper-Dependent Adenoviral Vectors [PDF]

Human Gene Therapy, 2013
Helper-dependent adenoviral vectors (HDAd) have been shown to mediate a considerably longer duration of transgene expression than first-generation adenoviral vectors. We have previously shown that transgene expression from HDAd-transduced hepatocytes can persist at high levels for up to 2.6 years in nonhuman primates following a single-vector ...
Thomas S C Ng, Nicola Brunetti-Pierri, Mark A. Law   +2 more
exaly   +4 more sources