Results 31 to 40 of about 1,008,618 (142)

Retardation of atherosclerosis in immunocompetent apolipoprotein (apo) E-deficient mice followingliver-directed administration of a [E1-, E3-,polymerase-] adenovirus vector containing the elongation factor-1a promoter driving expression of human apoE cDNA [PDF]

, 2005
Although gene transfer of human apolipoprotein E (apoE), a 34-kDa circulating glycoprotein, to the liver of apoEdeficient(apoE-/-) mice using recombinant adenoviral vectors (rAd) is antiatherogenic, its full therapeutic potentialhas yet to be realized ...
Stannard, AK, Amalfitano, A, Owen, JS, Dickson, G, Schepelmann, S, Graham, IR, Harris, JD   +6 more
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A zoonotic adenoviral human pathogen emerged through genomic recombination among human and nonhuman simian hosts

, 2019
Genomics analysis of a historically intriguing and predicted emergent human adenovirus (HAdV) pathogen, which caused pneumonia and death, provides insight into a novel molecular evolution pathway involving “ping-pong” zoonosis and anthroponosis.
Shoaleh Dehghan (14621531), Ramana Madupu (2834), Morris Saffold Jones (16784919), Elizabeth B. Liu (16780326), Ashrafali Mohamed Ismail (16784916), Jason Seto (329604), James C. Chodosh (16780332), Albert Heim (238424), David W. Dyer (13759138), Donald Seto (3729)   +9 more
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Kidney Transplant Recipients Develop Nasal Mucosal Antibodies to SARS‐CoV‐2 With ACE2‐Inhibiting Activity Following mRNA Vaccination

Transplant Infectious Disease, Volume 28, Issue 4, July/August 2026.
Kidney transplant recipients develop nasal mucosal antibodies after systemic COVID‐19 vaccination, which are able to inhibit binding of SARS‐CoV‐2 to the ACE2 receptor, but at a lower concentration than the general population. ABSTRACT Background Less than 60% of kidney transplant recipients (KTRs) become IgG seropositive for the viral spike (S ...
Vera J. C. H. Koomen, Christa E. van der Gaast‐deJongh, Fred van Opzeeland, Ria Philipsen, Marije C. Baas, A. Lianne Messchendorp, Frederike J. Bemelman, Marcia M. L. Kho, Carla C. Baan, Debbie van Baarle, Jan‐Stephan F. Sanders, Rob van Binnendijk, Gerco den Hartog, Ron T. Gansevoort, Renate G. van der Molen, Luuk B. Hilbrands, Dimitri A. Diavatopoulos   +16 more
wiley   +1 more source

Respiratory Syncytial Virus Under the Lens of Structure: From Prefusion Stabilization to Next‐Generation Immunotherapies

iNew Medicine, Volume 2, Issue 2, June 2026.
This illustration integrates key concepts covered in the review, including high‐risk populations, viral structure, host entry factors, the replication cycle, and licensed antibody‐based prevention strategies. ABSTRACT Respiratory syncytial virus (RSV) is a negative‐sense RNA virus belonging to the genus Orthopneumovirus within the family Pneumoviridae.
Zekai Cheng, Qianqian Wang, Jiachen Zhang, Sandra Chiu   +3 more
wiley   +1 more source

Intensive pharmacological immunosuppression allows for repetitive liver gene transfer with recombinant adenovirus in nonhuman primates [PDF]

, 2009
Repeated administration of gene therapies is hampered by host immunity toward vectors and transgenes. Attempts to circumvent antivector immunity include pharmacological immunosuppression or alternating different vectors and vector serotypes with the same
Dubrot, J. (Juan), Smerdou, C. (Cristian), Alfaro, C. (Carlos), Unzu, C. (Carmen), Palazon, A. (Asís), Mancheño, U. (Uxua), Mauleon, I. (Itsaso), Prieto, J. (Jesús), Benito-Boilos, A. (Alberto), Peñuelas-Sanchez, I. (Ivan), Sampedro, A. (Ana), Collantes, M. (María), Fontanellas-Romá, A. (Antonio), Hervas-Stubbs, S. (Sandra), Melero, I. (Ignacio)   +14 more
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Organoids: From Bench to Bedside Applications

MedComm, Volume 7, Issue 6, June 2026.
Organoids, as a groundbreaking biomedical research platform, utilize adult stem cells (ASCs), embryonic stem cells (ESCs), and induced pluripotent stem cells (iPSCs) as sources. By integrating specific growth and differentiation signals within an extracellular matrix (e.g., Matrigel), organoids guide cells to self‐assemble into three‐dimensional ...
Kelin Li, Rui Cao, Maochen Li, Zichao Tian, Huahao Fan, Bixia Hong, Xiaojuan Liu   +6 more
wiley   +1 more source

Sodium butyrate ameliorates renal tubular lipid accumulation through a protein phosphatase 2A/transcription factor EB axis in diabetic nephropathy

British Journal of Pharmacology, Volume 183, Issue 9, Page 1901-1919, May 2026.
Abstract Background and Purpose Extensive evidence indicates that lipid accumulation causes renal tubular injury, which further contributes to diabetic nephropathy (DN) progression. Short‐chain fatty acids (SCFAs) play an important role in the maintenance of cellular metabolic health.
Jiayin Tao, Sinan Ai, Yaoxian Wang, Yuning Liu, Jingwei Zhou, Qingqing Liu, Xu Wang, Danting Li, Xin Li, Lin Wang, Jinyi Hou, Liang Peng, Zhen Wang   +12 more
wiley   +1 more source

Delivery of human apolipoprotein (apo) E to liver by an [E1(-), E3(-), polymerase(-), pTP(-)] adenovirus vector containing a liver-specific promoter inhibits atherogenesis in immunocompetent apoE-deficient mice [PDF]

, 2006
Recombinant adenovirus (rAd)-mediated apoE gene transfer to the liver of apoE(-/-) mice is anti-atherogenic. However, first generation rAd vectors were associated with immune clearance of transduced hepatocytes, while an improved [E1(-), E3(-) polymerase(
Amalfitano, A, Owen, JS, Dickson, G, Graham, IR, Harris, JD   +4 more
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Modification of liposomal concentration in liposome/adenoviral complexes allows significant protection of adenoviral vectors from neutralising antibody, in vitro

, 2005
Adenoviral vectors have been commonly used in gene therapy protocols, however the success of their use is often limited by the induction of host immunity to the vector.
Kalle, Wouter H.J., Dingwall, Daniel J., Cavanagh, Heather M. A., Burton, Mark A., Steel, Jason C.   +4 more
core   +1 more source

Design and characterization of nonhuman adenoviral vectors

, 2005
The goal of this research was to examine the feasibility of designing gene delivery vectors based on nonpathogenic bovine adenovirus serotype 3 (BAd3) and porcine adenovirus serotype 3 (PAd3).
Singh, Dinesh Bangari
core   +1 more source