Results 21 to 30 of about 1,008,618 (142)

Systemic reactions after first and second dose with mRNA and adenoviral vector vaccines.

, 2022
Systemic reactions after first and second dose with mRNA and adenoviral vector vaccines.
Sara Sariyan (12859459), Vanya Rangelova (12859453), Ani Kevorkyan (12859462), Ralitsa Raycheva (12859456)   +3 more
core   +1 more source

Neonatal Genetic Delivery of Anti-Respiratory Syncytial Virus (RSV) Antibody by Non-Human Primate-Based Adenoviral Vector to Provide Protection against RSV

Vaccines, 2018
Respiratory syncytial virus (RSV) is one of the leading causes of lower respiratory tract infection in infants. Immunoprophylaxis with the anti-RSV monoclonal antibody, palivizumab, reduces the risk for RSV-related hospitalizations, but its use is ...
Rika Gomi, Anurag Sharma, Wenzhu Wu, Stefan Worgall   +3 more
doaj   +1 more source

Enhancement of Mucosal Immunogenicity of Viral Vectored Vaccines by the NKT Cell Agonist Alpha-Galactosylceramide as Adjuvant

Vaccines, 2014
Gene-based vaccination strategies, specifically viral vectors encoding vaccine immunogens are effective at priming strong immune responses. Mucosal routes offer practical advantages for vaccination by ease of needle-free administration, and immunogen ...
Shailbala Singh, Pramod N. Nehete, Guojun Yang, Hong He, Bharti Nehete, Patrick W. Hanley, Michael A. Barry, K. Jagannadha Sastry   +7 more
doaj   +1 more source

Tropism-modification strategies for targeted gene delivery using adenoviral vectors [PDF]

, 2010
Achieving high efficiency, targeted gene delivery with adenoviral vectors is a long-standing goal in the field of clinical gene therapy. To achieve this, platform vectors must combine efficient retargeting strategies with detargeting modifications to ...
Coughlan, L., Raul Alba, Coughlan, Lynda, Mcneish, I.A., Andrew H. Baker, Iain A. McNeish, Alba, R., Lynda Coughlan, Parker, Alan L., Nicklin, Stuart A., Bradshaw, Angela C., Bradshaw, A.C., Nicklin, S., Angela C. Bradshaw, Alan L. Parker, Stuart A. Nicklin, McNeish, Iain A., Baker, Andrew H., Parker, A.L., Alba, Raul, Baker, A.   +20 more
core   +1 more source

17. Biodistribution, Innate Immune Response and Toxicity Following Intravenous Inoculation of Mice with Nonhuman Adenoviral Vectors

Molecular Therapy, 2006
Nonhuman adenoviral (Ad) vectors have shown the potential to overcome the preexisting Ad immunity. In order to assess their utility for in vivo applications, it is important to evaluate biodistribution, induction of innate immune response, and toxicity of these vectors in a suitable animal model.
Bangari, Dinesh S., Sharma, Anurag, Pandey, Aseem, HogenEsch, Harm, Mittal, Suresh K.   +4 more
openaire   +1 more source

What Makes an “Ideal” Cell Line for Recombinant Adeno‐Associated Virus Production?

Biotechnology and Bioengineering, EarlyView.
Several host cell types have been used to produce rAAVs to date. Cell line‐specific traits that are beneficial in the context of rAAV manufacturing are reviewed here, with the goal of developing a consensus on the ‘ideal’ characteristics that an rAAV production host should possess (created with Biorender.com).
James Conheady, Nicholas Donohue, Alexandra Bogdanovic, Sharon Davin, Brian Glennon, Niall Barron, C. Mark Smales   +6 more
wiley   +1 more source

Sustained high-level expression of human factor IX (hFIX) after liver-targeted delivery of recombinant adeno-associated virus encoding the hFIX gene in rhesus macaques [PDF]

, 2002
The feasibility, safety, and efficacy of liver-directed gene transfer was evaluated in 5 male macaques (aged 2.5 to 6.5 years) by using a recombinant adeno-associated viral (rAAV) vector (rAAV-2 CAGG-hFIX) that had previously mediated persistent ...
Hanawa, H, Ng, CYC, Mandrell, TD, Vanin, EF, Nathwani, AC, Hu, Y, Davidoff, AM, Hoffer, FA, Zhou, J, Slaughter, C, Nikanorov, A, Lozier, JN, Nienhuis, AW   +12 more
core  

Animal models of anemia of inflammation: Methodological advances, limitations, and translational applications

Animal Models and Experimental Medicine, Volume 9, Issue 10, Page 1982-2000, October 2026.
Anemia of inflammation is a highly prevalent secondary anemia complicating chronic inflammatory diseases. Current animal models are categorized into sterile inflammation, disease‐specific, and genetically engineered models, with comparative analysis of their modeling principles, characteristic phenotypes, and translational advantages to elucidate core ...
Jiayi Cheng, Xiaodi Zhou, Qian Liu, Zixian Liu, Hao Wu   +4 more
wiley   +1 more source

Clinical Progression, Viral Load Dynamics, and Immune Kinetics of Nipah Virus Infection: Nipah Virus Kinetics Study Protocol

Current Protocols, Volume 6, Issue 10, October 2026.
Abstract Background: Nipah virus (NiV) is a zoonotic pathogen with pandemic potential. Understanding the immune response to this pathogen is important for developing vaccines and therapeutics. This study aims to characterize viral load, host immune kinetics, and biomarker progression throughout NiV infection.
Anika Farzin, Shadman Sakib Choudhury, Wasik Rahman Aquib, Sharmin Sultana, Mintu Chowdhury, Faruq Abdulla, Arifa Nazneen, Kamal Ibne Amin Chowdhury, Tonmoy Sarkar, Dewan Imtiaz Rahman, Mohammad Mamun Alam, Md. Mahfuzur Rahman, Ayesha Siddika, Tahsin Tabassum Anonto, Sinthia Karim, Md. Taufiqur Rahman Bhuiyan, Christina F. Spiropoulou, Michael K. Lo, Trevor Shoemaker, Mohammed Ziaur Rahman, Sayera Banu, Tahmina Shirin, Firdausi Qadri, Joel M. Montgomery, Syed Moinuddin Satter   +24 more
wiley   +1 more source

Mucosal‐Associated Invariant T Cells in Health and Disease

MedComm, Volume 7, Issue 10, October 2026.
The roles of MAIT cells in health and disease and their therapeutic applications. In healthy individuals, riboflavin metabolites secreted by commensal bacteria at mucosal sites are presented by MR1, leading to the activation of MAIT cells. Activated MAIT cells can maintain the barrier integrity of mucosal tissues in a steady state or migrate to the ...
Yu Zhao, Feng‐Mi Ou, Dan Liang, Yang Gao, Qing‐Qing Li, Yi‐Qun Kuang   +5 more
wiley   +1 more source