Results 41 to 50 of about 1,008,618 (142)

Evaluation of ocular distribution and local inflammatory response after a subconjunctival injection of adenoviral vector in the rats.

, 2016
Evaluation of ocular distribution and local inflammatory response after a subconjunctival injection of adenoviral vector in the rats.
Jia Hui Lee (834278), Pei-Jhen Tsai (834279), Shwu-Jiuan Sheu (834280), Gregory J. Dusting (406741), Jiang-Hui Wang (834277), Youn-Shen Bee (834281), Hsiu-Chen Lin (184579), Han-En Tsai (394086), Guei-Sheung Liu (394096), Ming-Hong Tai (394095)   +9 more
core   +1 more source

Toxicological Vulnerabilities and Emerging Safety Signals in Modified mRNA Vaccine Technology: A Narrative Review of the COVID‐19 Experience

Journal of Toxicology, Volume 2026, Issue 1, 2026.
The rapid deployment in early 2021 of modified mRNA (modRNA) as a vaccine platform for the COVID‐19 pandemic sparked a wave of optimism for its potential as a preventive medicine. However, this compacted timeframe may not have fully addressed certain toxicological risks associated with this new technology, which would typically require more extensive ...
Gerry A. Quinn, Philipp Bagus, Antonio Sánchez-Bayón, Ronan Connolly, Clare Craig, Paul Frijters, Steven J. Hatfill, Anton O’Connor, Daniel Santiago, Ricardo F. Savaris, Michaéla C. Schippers, Willie Soon, Demetrios A. Spandidos, Helmut Sterz, Aristidis M. Tsatsakis, Harald Walach, Phuping sucharitakul   +16 more
wiley   +1 more source

Efficacy of Immunostimulatory Adjuvants and Nano‐Adjuvants in Current SARS‐CoV‐2 Vaccines: A Comprehensive Review

Health Science Reports, Volume 8, Issue 11, November 2025.
ABSTRACT Background and Aims SARS‐CoV‐2 continues to pose global challenges, and current vaccines face limitations (variant escape, waning immunity). This review evaluates immunostimulatory adjuvants and nano‐adjuvants to enhance immune responses and optimize SARS‐CoV‐2 vaccine performance.
Peyman Kheirandish Zarandi, Mohammad Reza Zinatizadeh, Mohsen Ghiasi, Mohammad Rezaei Zadeh Rukerd, Hanieh Mirkamali, Ehsan Shokri   +5 more
wiley   +1 more source

Supplementary Fig. S2 from Adenoviral endoplasmic reticulum–targeted mda-7/interleukin-24 vector enhances human cancer cell killing

, 2008
Supplementary Fig. S2 from Adenoviral endoplasmic reticulum–targeted mda-7/interleukin-24 vector enhances human cancer cell ...
Wenxian Hu (184393), Stephen G. Swisher (11409528), Sunil Chada (14872290), Kelly K. Hunt (14886636), Abujiang Pataer (15038277), Lu Xiaolin (15038280), Jack A. Roth (170026)   +6 more
core   +1 more source

Age‐Dependent Histone Deacetylase 3 Regulation by βA3/A1‐Crystallin and Inositol Hexaphosphate in Retinal Pigmented Epithelial Cells Reveals a Novel Pathway in Age‐Related Macular Degeneration

Aging Cell, Volume 24, Issue 9, September 2025.
βA3/A1‐crystallin regulates HDAC3 activity and epigenetic processes in the RPE. (A) The illustration demonstrates that βA3/A1‐crystallin plays a crucial role in maintaining IPMK protein expression, which in turn activates HDAC3. (B) When βA3/A1‐crystallin is absent (Cryba1 KO ), IPMK protein expression decreases, resulting in the deactivation of HDAC3.
Sujan Chatterjee, Sayan Ghosh, Zachary Sin, Vishnu Suresh Babu, Loretta Viera Preval, Emily Davis, Nguyen Tran, Sridhar Bammidi, Pooja Gautam, Stacey Hose, Yuri Sergeev, Miguel Flores‐Bellver, Kevin Ritter, Henning J. Jessen, Issam Al Diri, Debasish Sinha, Prasun Guha   +16 more
wiley   +1 more source

Supplementary Fig. S1 from Adenoviral endoplasmic reticulum–targeted mda-7/interleukin-24 vector enhances human cancer cell killing

, 2008
Supplementary Fig. S1 from Adenoviral endoplasmic reticulum–targeted mda-7/interleukin-24 vector enhances human cancer cell ...
Wenxian Hu (184393), Stephen G. Swisher (11409528), Sunil Chada (14872290), Kelly K. Hunt (14886636), Abujiang Pataer (15038277), Lu Xiaolin (15038280), Jack A. Roth (170026)   +6 more
core   +1 more source

Immune Control of AIDS Progression by an Adenovirus‐Based Therapeutic Vaccination in Acute Simian Immunodeficiency Virus‐Infected Macaques

MedComm, Volume 6, Issue 8, August 2025.
This proof‐of‐concept study confirms that the GM‐CSF‐mediated adenovirus‐based SIV vaccine delivery strategy in combination with ART enhances antiviral immunity during acute infection. This strategy delays viral rebound and disease progression following ART by maintaining specific T cell responses and reducing immune activation.
Yizi He, Chunxiu Wu, Fengling Feng, Zijian Liu, Xugang Zhang, Qing Yang, Zhe Chen, Minjuan Shi, Ziyu Wen, Yichu Liu, Fengyu Hu, Linghua Li, Caijun Sun, Ling Chen, Pingchao Li   +14 more
wiley   +1 more source

Assessment of CAR- or CD46-Dependent Adenoviral Vector-Mediated TRAIL Gene Therapy in Clinical Adenocarcinoma Lung Cancer Cells

, 2009
Adenoviral vector-mediated transfer of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) can be a powerful approach to lung cancer therapy.
Fan, Xiaolong,, Fan, Xiaolong, Bao, Yongyi, Wang, Shizhong, Guan, Naifu, Ma, Lingdi, Ni, Cheng, Lund University., Zhao, Jianzhong, Wang, Yong, Shizhong Wang, Yongyi Bao, Naifu Guan, Xiaolong Fan, Cheng Ni, Jianzhong Zhao, Lingdi Ma, Yong Wang   +17 more
core   +1 more source

Differential integrity of TALE nuclease genes following adenoviral and lentiviral vector gene transfer into human cells [PDF]

, 2013
The array of genome editing strategies based on targeted double-stranded DNA break formation have recently been enriched through the introduction of transcription activator-like type III effector (TALE) nucleases (TALENs).
Holkers, Maarten, Liu J, Janssen, Josephine M., Recchia, A., Maggio, Ignazio, Gonçalves MA, Goncalves, M.A.F.V., Mussolino, C., Holkers, M., Miselli F, Liu, J., Cathomen, Toni, Mussolino, Claudio, Miselli, Francesca, RECCHIA, Alessandra, Cathomen, T., Liu, Jin, Maggio, I., Gonçalves, Manuel A. F. V., Mussolino C, Miselli, F., Holkers M, Maggio I, Janssen JM, Janssen, J.M., Cathomen T   +25 more
core   +1 more source

Why acute inflammatory response can happen after Adenoviral Vector Vaccines; Is the interleukin 6 the secret and how circumvent that, Is by adding polyethylene glycol (PEG)?

, 2021
Adenoviral vector vaccines induce an acute immunogenic response that varies according to the immune status of the individuals injected. The excipient used in the vaccine injection can either increase or decrease the severity of this acute immune response.
Amr Kamel Khalil Ahmed
core   +1 more source