Results 51 to 60 of about 1,008,618 (142)

Efficient Gene Transfer and Expression in Islets by an Adenoviral Vector that Lacks All Viral Genes

, 1999
Although adenoviral vector-mediated gene transfer has significant potential for gene therapy, host immune responses to virally expressed proteins and small insert capacity may limit its clinical application.
Deepak Mital, Stephen C. Jensik, Yuanze Hong, James W. Williams, Zhiguang Guo, Ramon Alemany, Wei-Wei Zhong, Jikun Shen   +7 more
core   +1 more source

Short-Term Adverse Effects Following Booster Dose of Inactivated-Virus vs. Adenoviral-Vector COVID-19 Vaccines in Algeria: A Cross-Sectional Study of the General Population

, 2022
COVID-19 booster vaccines have been adopted in almost all countries to enhance the immune response and combat the emergence of new variants. Algeria adopted this strategy in November 2021.
Djihad Bencherit, Abdelhadi, Samir, Salem Belkessa, Samir Abdelhadi, Mohamed Lounis, Aouissi, Hani Amir, Rais, Mohammed Amir, Belkessa, Salem, Hani Amir Aouissi, Lounis, Mohamed, Bencherit, Djihad, Mohammed Amir Rais   +11 more
core   +1 more source

815. Aerosol Delivery of Helper-Dependent Adenoviral Vector into Nonhuman Primate Lungs Results in High Efficiency Pulmonary Transduction with Minimal Toxicity

Molecular Therapy, 2005
Cystic fibrosis is caused by recessive mutations in a membrane chloride channel gene (CFTR) expressed in the airway epithelium and is characterized by persistent, progressive inflammation and infection, eventually leading to lung failure. A major obstacle to CF gene therapy is inefficient pulmonary transduction by viral and nonviral vectors in large ...
openaire   +1 more source

Abstracts

Molecular Oncology, Volume 20, Issue S1, Page 1-692, August 2026.
Abstracts submitted to the ‘EACR 2026 Congress: Innovative Cancer Science’, from 08–11 June 2026 and accepted by the Congress Organising Committee are published in this Supplement of Molecular Oncology, an affiliated journal of the European Association for Cancer Research (EACR).
wiley   +1 more source

Altering the Ad5 packaging domain affects the maturation of the Ad particles [PDF]

, 2011
We have previously described a new family of mutant adenoviruses carrying different combinations of attB/attP sequences from bacteriophage PhiC31 flanking the Ad5 packaging domain.
Alba Fernández, Raúl, Raul Alba, Assumpcio Bosch, Chillon Miguel, Philomena Ostapchuk, Cots Dan, Hearing Patrick, Hearing, P., Alba, R., Ostapchuk Philomena, Bosch i Merino, Assumpció, Ostapchuk, Philomena, Alba Raul, Bosch Assumpcio, Miguel Chillon, Ostapchuk, P., Cots i Rabella, Dan, Cots, D., Chillón Rodríguez, Miguel, Chillon, M., Patrick Hearing, Hearing, Patrick, Bosch, A., Dan Cots   +23 more
core   +2 more sources

904. High Efficiency Hepatic Transduction and Long-Term Transgene Expression by Delivering Helper-Dependent Adenoviral Vectors into the Surgically Isolated Liver of Nonhuman Primates

Molecular Therapy, 2005
Helper-dependent adenoviral vectors (HDAd) are attractive vectors for liver-directed gene therapy because they can mediate long-term, high level transgene expression with no long-term toxicity. However, as a consequence of a threshold effect, high vector doses are required to achieve efficient hepatic transduction by peripheral intravenous injection ...
openaire   +1 more source

Replication-deficient Adenoviral Vector for Gene Transfer Potentiates Airway Neurogenic Inflammation [PDF]

, 1997
Human trials for the treatment of cystic fibrosis lung disease with adenoviral vectors have been complicated by acute inflammatory reactions of unknown etiology.
Boucher, Richard C., McCarty, Douglas, Piedimonte, Giovanni, Pickles, Raymond J., Costa, Daniel L., Lehmann, James R.   +5 more
core   +1 more source

Adenoviral vaccines-Infectious disease

Since the early 2000s, adenoviral vectors have been extensively used for the development of infectious disease vaccines. The first clinical vectors were derived from species C human adenovirus type 5 (HAdV-C5) and induced robust T cell and antibody ...
Douglas, Alexander D., Rollier, Christine S., Montalvo Zurbia-Flores, Gerardo, Bliss, Carly M., Wright, Daniel   +4 more
core   +1 more source

Prolonged effects of adenoviral vector priming on T-cell cytokine production in heterologous adenoviral vector/mRNA COVID-19 vaccination regimens

mRNA and adenoviral vector vaccine platforms were used for the primary series of COVID-19 vaccines in many countries. However, the distinct immunogenic properties on these platforms remain less understood.
Yoshio Hirota, Shinji Saito, Akira Ainai, Taishi Onodera, Masanori Isogawa, Megumi Hara, Yoshimasa Takahashi, Takayuki Kanno, Tadaki Suzuki, Minoru Tobiume, Tomomi Tsuru, Ryutaro Kotaki, Kenzo Tokunaga   +12 more
core   +1 more source

Comparative analysis of human and nonhuman adenoviral vectors for gene delivery

, 2009
Vectors based on nonhuman adenoviruses (Ads) such as porcine Ad serotype 3 (PAd3) and bovine Ad serotype 3 (BAd3) are being developed as alternative to human adenoviral (HAd) vectors to circumvent the problem of preexisting immunity in humans.
Sharma, Anurag
core   +1 more source