Results 21 to 30 of about 35,510 (163)

Inhibitors of metalloprotease, γ-sectretase, protein kinase C and Rho kinase inhibit wild-type adenoviral replication.

PLoS ONE, 2020
Adenoviruses cause upper respiratory infections, conjunctivitis, keratitis, and gastrointestinal illness. These can be fatal in immunocompromised individuals.
Alice Liu, Cristhian J Ildefonso, Wesley S Bond, Mary Y Hurwitz, Richard L Hurwitz   +4 more
doaj   +1 more source

Response Type and Host Species may be Sufficient to Predict Dose-Response Curve Shape for Adenoviral Vector Vaccines

Vaccines, 2020
Vaccine dose-response curves can follow both saturating and peaking shapes. Dose-response curves for adenoviral vector vaccines have not been systematically described.
John Benest, Sophie Rhodes, Sara Afrough, Thomas Evans, Richard White   +4 more
doaj   +1 more source

A Confirmatory, Dual Center Nonhuman Primate Study on the Efficacy of Novel Oropharyngeal Spray Immunization With an Adenoviral Vector Vaccine Against RSV-Important Lessons Learned. [PDF]

J Med Primatol
ABSTRACT Background In a randomized, blinded, dual center study across two European primate research facilities, we evaluated the immunogenicity and protective efficacy of a DNA prime—oropharyngeal adenoviral boost vaccination strategy against respiratory syncytial virus (RSV).
Tenbusch M, Koopman G, Mooij P, Roshani B, Irrgang P, Lapuente D, Kondova I, Bogers WM, Remarque EJ, Vestweber R, Merida Ruiz SA, Krüger N, Meyer S, Gefeller O, Stahl-Hennig C, Überla K.   +15 more
europepmc   +2 more sources

Pre-clinical characterization of GMP grade CCL21-gene modified dendritic cells for application in a phase I trial in Non-Small Cell Lung Cancer

Journal of Translational Medicine, 2008
Background Our previous studies have demonstrated that transduction of human dendritic cells (DC) with adenovirus encoding secondary lymphoid chemokine, CCL21, led to secretion of biologically active CCL21 without altering DC phenotype or viability.
Sharma Sherven, Batra Raj K, Zeng Gang, Kurimoto Pam S, Luo Jie, Peebles Katherine, Hazra Saswati, Takedatsu Hiroko, Baratelli Felicita, Dubinett Steven M, Lee Jay M   +10 more
doaj   +1 more source

Development of novel vaccine vectors: Chimpanzee adenoviral vectors

Human Vaccines & Immunotherapeutics, 2018
Adenoviral vector has been employed as one of the most efficient means against infectious diseases and cancer. It can be genetically modified and armed with foreign antigens to elicit specific antibody responses and T cell responses in hosts as well as ...
Jingao Guo, Moumita Mondal, Dongming Zhou   +2 more
doaj   +1 more source

Co-Targeting Prostate Cancer Epithelium and Bone Stroma by Human Osteonectin-Promoter-Mediated Suicide Gene Therapy Effectively Inhibits Androgen-Independent Prostate Cancer Growth. [PDF]

PLoS ONE, 2016
Stromal-epithelial interaction has been shown to promote local tumor growth and distant metastasis. We sought to create a promising gene therapy approach that co-targets cancer and its supporting stromal cells for combating castration-resistant prostate ...
Shian-Ying Sung, Junn-Liang Chang, Kuan-Chou Chen, Shauh-Der Yeh, Yun-Ru Liu, Yen-Hao Su, Chia-Yen Hsueh, Leland W K Chung, Chia-Ling Hsieh   +8 more
doaj   +1 more source

A novel and simple method for rapid generation of recombinant porcine adenoviral vectors for transgene expression. [PDF]

PLoS ONE, 2015
Many human (different serotypes) and nonhuman adenovirus vectors are being used for gene delivery. However, the current system for isolating recombinant adenoviral vectors is either time-consuming or expensive, especially for the generation of ...
Peng Zhang, Enqi Du, Jing Ma, Wenbin Wang, Lu Zhang, Suresh K Tikoo, Zengqi Yang   +6 more
doaj   +1 more source

Adenoviral Vector-Based Vaccine Expressing Hemagglutinin Stem Region with Autophagy-Inducing Peptide Confers Cross-Protection Against Group 1 and 2 Influenza A Viruses

Vaccines
Background/Objectives: An effective universal influenza vaccine is urgently needed to overcome the limitations of current seasonal influenza vaccines, which are ineffective against mismatched strains and unable to protect against pandemic influenza ...
Wen-Chien Wang, Ekramy E. Sayedahmed, Marwa Alhashimi, Ahmed Elkashif, Vivek Gairola, Muralimanohara S. T. Murala, Suryaprakash Sambhara, Suresh K. Mittal   +7 more
doaj   +1 more source

Intranasal adenoviral neuraminidase vaccine induces local and systemic immunity and homosubtypic protection against influenza A viruses

Frontiers in Immunology
IntroductionThe rapid antigenic drift of influenza A hemagglutinin (HA) limits the effectiveness of current HA-focused vaccines. To address this challenge, we evaluated recombinant human (HAd) and bovine (BAd) adenoviral vectors expressing neuraminidase (
Wen-Chien Wang, Weiping Cao, Amrita Kumar, Wadzanai P. Mboko, Ram Kamal, Ekramy E. Sayedahmed, Suresh K. Mittal   +6 more
doaj   +1 more source

Adenoviral vaccines promote protective tissue-resident memory T cell populations against cancer

Journal for ImmunoTherapy of Cancer, 2020
Background Adenoviral vectors emerged as important platforms for cancer immunotherapy. Vaccination with adenoviral vectors is promising in this respect, however, their specific mechanisms of action are not fully understood.
Paul Klenerman, Suzanne van Duikeren, Ramon Arens, Frits Koning, Hideo Yagita, Esmé TI van der Gracht, Mark JA Schoonderwoerd, Ayse N Yilmaz, Felix M Behr, Julia M Colston, Lian N Lee, Klaas PJM van Gisbergen, Lukas JAC Hawinkels   +12 more
doaj   +1 more source