Results 121 to 130 of about 70,698 (266)

Efficient adenoviral transduction of 3T3-F442A preadipocytes without affecting adipocyte differentiation

, 2005
International audienceThe preadipocyte cell lines 3T3-L1 and 3T3-F442A are widely used to study the cellular mechanisms of preadipocyte differentiation and mature adipocyte functions.
Auclair, Martine, Béréziat, Véronique, Vigouroux, Corinne, Klonjkowski, Bernard, Capeau, Jacqueline, Eloit, Marc, Moritz, Sylviane, Decaudain, Aurélie   +7 more
core   +1 more source

From patient to tumor organoid: Culture protocol choice controls glioblastoma tumor architecture and identity

Brain Pathology, EarlyView.
How glioblastoma organoids are made shapes what they become. Fragment‐based cultures preserve extracellular matrix networks, cellular diversity, and primary tumor identity, whereas dissociation‐based cultures shift toward growth‐adapted states and simplified microenvironments. Abstract Patient‐derived tumor organoids are widely used in cancer research,
Jana Slovackova, Ondrej Bernatik, Katarina Cimborova, Martin Barak, Michal Hendrych, Karolina Kocourkova, Marie Sulcova, Jaroslav Olha, Katerina Amruz Cerna, Zdenek Hodny, Radim Jancalek, Dasa Bohaciakova   +11 more
wiley   +1 more source

Strategies for Modifying Adenoviral Vectors for Gene Therapy

Adenoviral vectors (AdVs) are effective vectors for gene therapy due to their broad tropism, large capacity, and high transduction efficiency, making them widely used as oncolytic vectors and for creating vector-based vaccines. This review also considers
Svetlana Smirnikhina, Muravyeva, Anna, Anna Muravyeva, Smirnikhina, Svetlana   +3 more
core   +1 more source

An intracellular recombinant single‐chain variable antibody fragment as a new class of phosphodiesterase type 5 inhibitors

British Journal of Pharmacology, EarlyView.
Background and Purpose Cyclic guanosine monophosphate (cGMP) is a ubiquitous second messenger involved in human (patho‐)physiology. Phosphodiesterase 5 (PDE5) is a major cGMP hydrolyzing enzyme in many cell types including vascular smooth muscle cells (VSMCs). Several highly selective PDE5 inhibitors are in clinical use. However, there are currently no
Kürsat Kirkgöz, Sophie Sprenger, Olga Schweigert, Sanika Mohagaonkar, Matti Walsdorff, Tanja Zeller, Filip Berisha, Viacheslav O. Nikolaev, Sergei D. Rybalkin   +8 more
wiley   +1 more source

Histological analysis of mice from mild VM model with GFP or SPARC adenoviral overexpression.

, 2019
Histological analysis of mice from mild VM model with GFP or SPARC adenoviral overexpression.
Anna-Pia Papageorgiou (800209), Daniel M. Johnson (449272), Elza Van Deel (6532949), Karin R. Sipido (341950), Paolo Carai (800207), Jolanda Van der Velden (6532952), Sophie Deckx (800206), Marieke Rienks (6532946), Stephane Heymans (169477)   +8 more
core   +1 more source

Therapeutic potential of natural products in cancer immunotherapy: Advances and challenges

British Journal of Pharmacology, EarlyView.
This review systematically outlines the mechanisms underlying tumour immunotherapy resistance and elucidates the role of natural products in enhancing therapeutic efficacy as immunomodulatory adjuvants. Abstract Immunotherapy has emerged as a clinically pivotal approach in cancer treatment, but its application remains limited to a small subset of ...
Rao Hu, Kaibin Dai, Zhensheng Lin, Mingfang Ye, Minfeng Chen, Xiaobo Li, Dongmei Zhang   +6 more
wiley   +1 more source

Atrial natriuretic peptide counteracts aldosterone secretion by preventing acute angiotensin II‐induced cAMP signalling

British Journal of Pharmacology, EarlyView.
Background and Purpose Aldosterone plays a key role in blood pressure and volume regulation. Enhanced aldosterone secretion contributes to cardiovascular and renal diseases. Therefore, inhibitors of aldosterone receptors and synthase are essential drugs for the treatment of hypertension and heart failure.
Sanika Mohagaonkar, Egor B. Skryabin, Bettina M. Buchholz, Michaela Kuhn, Celso E. Gomez‐Sanchez, Stepan Gambaryan, Viacheslav O. Nikolaev   +6 more
wiley   +1 more source

Numbers of respiratory adenoviral isolates collected at National Cheng Kung University Hospital from 2002 to 2011.

, 2013
Numbers of respiratory adenoviral isolates collected at National Cheng Kung University Hospital from 2002 to 2011.
Shih-Min Wang (461256), Chia-Yu Chi (309612), Ih-Jen Su (87501), Huey-Pin Tsai (461255), Pin-Hwa Kuo (461254), Shan-Li Wang (461253), Jen-Ren Wang (198419), Ching-Chuan Liu (461257)   +7 more
core   +1 more source

Long non‐coding RNAs at the crossroads of inflammation, cancer and angiogenesis: Molecular mechanisms and their potential as therapeutic targets

British Journal of Pharmacology, EarlyView.
Long non‐coding RNAs (lncRNAs), a broad class of non‐protein‐coding RNAs, are characterized as new regulators of gene expression at the epigenetic, transcriptional, and post‐transcriptional level. Thus, lncRNAs are involved in the regulation of physiological processes and the development of human diseases and cancer by modulating proinflammatory ...
Charlie Leboff, Pamela Calle‐Mendoza, Maria Hatziapostolou, Christos Polytarchou   +3 more
wiley   +1 more source

Challenges in Gene‐Directed Therapies for Rare Neurodevelopmental Disorders Using HNRNPU as an Exemplar

Clinical Genetics, EarlyView.
Beyond diagnosing rare neurodevelopmental disorders like HNRNPU‐RNDD, developing gene‐directed therapies requires overcoming complex hurdles, including spatial, developmental, and cell‐type constraints. Addressing these requires understanding the molecular effects of dosage and chromatin dynamics to deliver precise, effective treatments.
Daniel Aiyedun, Susan F. Rogers, Doaa M. Taha, Meena Balasubramanian   +3 more
wiley   +1 more source