Results 101 to 110 of about 70,698 (266)

Genetic epilepsies with myoclonic seizures: Mechanisms and syndromes

Epilepsia Open, EarlyView.
Abstract Genetic epilepsy with myoclonic seizures encompasses a heterogeneous spectrum of conditions, ranging from benign and self‐limiting forms to severe, progressive disorders. While their causes are diverse, a significant proportion stems from genetic abnormalities.
Antonietta Coppola, Marica Rubino, Antonella Riva, Pasquale Striano   +3 more
wiley   +1 more source

Pulmonary Inflammation Induced by Incomplete or Inactivated Adenoviral Particles [PDF]

, 1995
Overview summary The amount of pulmonary inflammation induced in mice by intratracheal administration of high doses of adenoviral vectors was compared to that induced by viral particles that lack the ability to express the genes that they contain.
Roessler, Blake J., Laing, Timothy J., Huffnagle, Gary B., Janich, Sonia L., McCoy, Ronald D., Simon, Richard H., Davidson, Beverly L.   +6 more
core   +1 more source

Dexpanthenol 5% as part of combined therapy in a patient with adenoviral keratoconjunctivitis associated with a history of keratorefractive surgery (case report) [PDF]

Клиническая офтальмология
Z.V. Surnina, M.N. Narbut, M.A. Makarova M.M. Krasnov Research Institute of Eye Diseases, Moscow, Russian Federation Adenoviral infection is considered to be one of the most common causes of conjunctivitis.
Z.V. Surnina, M.N. Narbut, M.A. Makarova
doaj  

Role of homologous recombination/recombineering on human adenovirus genome engineering: Not the only but the most competent solution

Engineering Microbiology
Adenoviruses typically cause mild illnesses, but severe diseases may occur primarily in immunodeficient individuals, particularly children. Recently, adenoviruses have garnered significant interest as a versatile tool in gene therapy, tumor treatment ...
Lisa-Marie Dawson, Montaha Alshawabkeh, Katrin Schröer, Fatima Arakrak, Anja Ehrhardt, Wenli Zhang   +5 more
doaj   +1 more source

Advanced viral genome in vitro Cas9 editing (AdVICE): an overnight method for traceless and limitless manipulation of adenoviral and vector genomes with large transgenes

Journal of Virology
The size and complexity of large viral genomes limit the technical possibilities for genome manipulations in fundamental research and medical or technological applications. State-of-the-art recombineering in bacteria has partially overcome this limit but
Jean-Baptiste Vergnes, Benoit Roger, Richard Iggo, Harald Wodrich   +3 more
doaj   +1 more source

Proinflammatory Tear Cytokines in Human Adenoviral Keratoconjunctivitis and Clinical Eye Severity [PDF]

Concepción Santacruz Valdés,1 Efrén Raúl Ponce-Rosas,2 Maria C Jimenez-Martinez3,4 1Department of Cornea and Refractive Surgery, Institute of Ophthalmology “Conde de Valenciana”, Mexico City, Mexico; 2Subdivision of Family Medicine, Department of ...
Ponce-Rosas ER, Jimenez-Martinez MC, Santacruz Valdés C   +2 more
core  

GSK3β drives early diabetic tubulopathy via TFEB‐mediated mitochondrial dysfunction

Interdisciplinary Medicine, EarlyView.
Mitochondrial dysfunction, including mitochondrial biogenesis, mitophagy, dynamics and oxidative stress, occurs in the early stages of diabetic tubulopathy, which precede proteinuria and renal histological changes. GSK3β is a potential novel biomarker for the prediction of diabetic tubulopathy.
Lan Yao, Xianhui Liang, Bingyu Li, Bohan Chen, Xiaoyang Wang, Mei Hong, Qi Feng, Yingjin Qiao, Zhangsuo Liu, Kai Wang, Pei Wang   +10 more
wiley   +1 more source

Microbial metabolite indole‐3‐propionic acid preserves astrocytic mitochondrial mitofusin 2 to limit neuroinflammation after traumatic brain injury

Interdisciplinary Medicine, EarlyView.
Following traumatic brain injury, indole‐3‐propionic acid (IPA) directly targets the aryl hydrocarbon receptor on astrocytes in the peri‐lesional cortex; this suppresses interferon regulatory factor 1‐driven transcription of the E3 ubiquitin ligase RFFL (ring finger and FYVE‐like domain containing E3 ubiquitin protein ligase).
Ziwen Zhang, Kai Wang, Liangbo Wang, Wencong Li, Hao Guo, Meng Xu, Tinghao Wang, Jiahui Ren, Ting Zhu, Jiahui Wang, Wenxing Cui, Jinpeng Zhou, Yang Tian, Liying Han, Chengxuan Guo, Shuoyao Ma, Qiang Wang, Zhihong Li, Yaning Cai, Jingyu Dong, Xun Wu, Haixiao Liu, Yan Qu   +22 more
wiley   +1 more source

Endoscopic findings in patients with Shwachman–Diamond syndrome: A report from the North American Shwachman–Diamond syndrome registry

JPGN Reports, EarlyView.
Abstract Objectives Shwachman–Diamond syndrome (SDS) is an inherited bone marrow failure disorder, and its endoscopic phenotype is poorly defined. We sought to characterize endoscopic findings in patients with genetically confirmed SDS. Methods Retrospective registry study of 45 patients with biallelic Shwachman–Bodian–Diamond syndrome mutations and ...
Elizabeth Korn, Jane Koo, Diana Schwarz, Meghan Haney, Juan Putra, Jaeson Kim, Leah Cheng, Sarah Steltz, Lois Schwarz, Sara Loveless, Richard Cooper, Claire Dusa, Kasiani C. Myers, Akiko Shimamura, Andrew Wehrman, Amit S. Grover   +15 more
wiley   +1 more source

Adenoviral Vector-Based Vaccine Expressing Hemagglutinin Stem Region with Autophagy-Inducing Peptide Confers Cross-Protection Against Group 1 and 2 Influenza A Viruses

Vaccines
Background/Objectives: An effective universal influenza vaccine is urgently needed to overcome the limitations of current seasonal influenza vaccines, which are ineffective against mismatched strains and unable to protect against pandemic influenza ...
Wen-Chien Wang, Ekramy E. Sayedahmed, Marwa Alhashimi, Ahmed Elkashif, Vivek Gairola, Muralimanohara S. T. Murala, Suryaprakash Sambhara, Suresh K. Mittal   +7 more
doaj   +1 more source