PECULIARITIES OF THE COURSE OF THE ADENOVIRAL OPHTALMOINFECTION IN PATIENTS WITH SYSTEMIC ALLERGY
Медицинский совет, 2016 The clinical course of the adenoviral ophthalmic infection is sufficiently variable. The gravity of clinical manifestations depends on many factors: the strain of the causative agent, dosage of the penetrated agent, the state of the local and systemic ...
E. V. YANI, K. E. SELIVERSTOVA
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Construction of Adenoviral vectors for cancer gene therapy and evaluation of toxic effects of adenoviral infection on Adrenocortical cells [PDF]
, 2008 Aims of the work were construction and evaluation of recombinant adenoviral vectors for gene therapy of esophageal, hepatocellular and adrenocortical carcinomas in vitro and in vivo. Since adenoviruses have tropism for adrenal gland, human adrenocortical
Matkovic, Urska
core
Structure-based design and optimization of potent inhibitors of the adenoviral protease
, 2015 Adenoviral infections are associated with a wide range of acute diseases, among which ocular viral conjunctivits (EKC) and disseminated disease in immunocompromised patients. To date, no approved specific anti-adenoviral drug is available, but there is a
Bernardi, Anna +22 more
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, 2020 Disseminated adenoviral disease in immunocompetent adults supported with extracorporeal membrane ...
Chang, G +5 more
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Engineering Biology Beyond Single Genes: Advances and Challenges in Multiplex Genome Editing
Animal Research and One Health, EarlyView.Multiplex genome editing is transforming genome engineering from single‐gene perturbation to network‐level control, yet its broader application remains limited by challenges in gRNA array engineering, delivery technologies, and safety management. Emerging AI‐driven approaches are accelerating guide RNA design and CRISPR effector optimization for ...
Linli Wang, Yongbin Liu, Hongbing Han
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Bilateral disciform keratitis of presumed adenoviral etiology
, 2018 Adenoviral conjunctivitis may lead to subepithelial corneal infiltrates as a late complication. Herein, we aim to present a 19-year-old healthy female, who developed bilateral disciform keratitis three weeks after suffering adenoviral conjunctivitis. She
Serkan Poyraz, Rana Altan-Yaycioglu
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MDL‐800‐induced SIRT6 activation decreases age‐associated osteoarthritis in mice
Arthritis &Rheumatology, Accepted Article.Objective SIRT6 is a nuclear‐localized histone deacetylase that regulates multiple pathways associated with aging. This study aimed to determine whether systemic administration of a small molecule activator of SIRT6, MDL‐800, decreases the severity of age‐associated osteoarthritis (OA) in mice.
Matheus Moreira Perez +13 more
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What Makes an “Ideal” Cell Line for Recombinant Adeno‐Associated Virus Production?
Biotechnology and Bioengineering, EarlyView.Several host cell types have been used to produce rAAVs to date. Cell line‐specific traits that are beneficial in the context of rAAV manufacturing are reviewed here, with the goal of developing a consensus on the ‘ideal’ characteristics that an rAAV production host should possess (created with Biorender.com).
James Conheady +6 more
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The Effects Of Povidone İodine (Ph 4.2) On Patients With Adenoviral Conjunctivitis
, 2016 Conclusion: A new treatment protocol of povidone-iodine was used safely in patients with adenoviral conjunctivitis.
Sakarya Üniversitesi/Tıp Fakültesi/Temel Tıp Bilimleri Bölümü +2 more
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E2A, VA RNA I, and L4-22k adenoviral helper genes are sufficient for AAV production in HEK293 cells
Molecular Therapy: Methods & Clinical DevelopmentThe replication-defective adeno-associated virus (AAV) is extensively utilized as a research tool or vector for gene therapy. The production process of AAV remains intricate, expensive, and mechanistically underexplored.
Jiten Doshi +4 more
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