Results 71 to 80 of about 70,698 (266)

Adenoviral-mediated Interleukin-15 Receptor-α gene therapy of murine breast cancer

, 2006
Interleukin-15 (IL-15) is a critical cytokine involved in the activation, proliferation and survival of natural killer (NK) and CD8+ T cells. The high-affinity IL-15 receptor (IL-15Rα) expressed on monocytes and dendritric cells supplies IL-15 in trans ...
Jason Steel (9837167), P Mannan (9888278), JC Morris (9888269), BJ Morrison (9888287), TA Waldmann (9888284), Y Tagaya (9888377), Y Sakai (6965684)   +6 more
core  

Influence of adenoviral transduction with Adv5-optHGF-RFP on phenotype of hepatic stellate cells

, 2020
Adenoviral transduction of hepatic stellate cells is applicable for short time stimulation of genes expression, safety for phenotype and cells proliferation.
Titova Angelina Andreevna, Zaikina Elvira Ildarovna, Rizvanov Albert Anatolevich, Mavlikeev Mihail Olegovich, Shafigullina Aygul Kasyjmovna, Kiyasov Andrey Pavlovich, Garanina Ekaterina Evgenevna, Gumerova Anisa Azatovna   +7 more
core  

Adenoviral DNA status as a function of mother’s demographics and infant gender.

, 2015
1The 95% confidence interval for the fraction of adenoviral DNA-positive samples was calculated according to the method of Agresti and Coull [19].Adenoviral DNA status as a function of mother’s demographics and infant gender.
Linda R. Gooding (701335), David A. Ornelles (701334), C. Garnett-Benson (701336)   +2 more
core   +1 more source

An Adenoviral‐Vectored Tp0326 Vaccine Elicits Robust Functional Antibodies to Prevent Treponema pallidum Dissemination in a Rabbit Model

Advanced Science, EarlyView.
Vaccination promotes cellular infiltration into primary lesions and effectively inhibits T. pallidum dissemination to distal organs. Notably, transfer of lesion tissue from immunized animals fails to establish infection in naive recipients, confirming specific protective immunity.
Yinbo Jiang, Xinyuan Li, Lixia Huang, Xiangcai Zhang, Wujian Ke   +4 more
wiley   +1 more source

Hepatic Lipid Stress Drives Metabolic Dysfunction‐Associated Steatohepatitis Progression through FTO O‐GlcNAcylation‐Induced m6A Demethylation of HRAS

Advanced Science, EarlyView.
Lipid stress drives O‐GlcNAcylation of the m6A demethylase FTO at Ser195, enhancing its stability and demethylase activity. This modification removes m6A from HRAS mRNA, preventing its degradation and activating PI3K/AKT signaling to promote hepatic steatosis and inflammation.
Jia‐Xin Yin, Yan‐Lai Zhang, Qun Liu, Rui Liu, Hai‐Yang Yuan, Sui‐Dan Chen, Ming‐Hua Zheng, Kai Wang, Ni Tang, Ai‐Long Huang   +9 more
wiley   +1 more source

Generation of a rabbit VH domain antibody polyspecific to c-Met and adenoviral knob protein

, 2006
Several types of bispecific antibodies with affinity to both adenoviral coat proteins and a targeted antigen have been developed with the aim of providing the specific delivery of adenoviral gene therapy vehicle.
윤채옥, 김주항
core   +2 more sources

Targeting Cannabinoid 1 Receptor in Macrophages Alleviates Psoriatic Skin Inflammation Through the AUF1–NLRP3 Axis

Advanced Science, EarlyView.
Macrophage CB1R emerges as a key driver of psoriatic inflammation by suppressing AUF1‐mediated post‐transcriptional control of NLRP3. CB1R inhibition restores AUF1‐dependent NLRP3 mRNA decay, restrains inflammasome activation, and alleviates psoriasis‐like inflammation.
Hongseo Choi, Sukyoung Han, Jinho Kim, Ji Hye Han, Eunsu Kim, Yeonjeong Heo, Minju Lee, Jooyoung Lee, Heerim You, Soyoun Lee, Su‐Hee Han, Ilrok Yoon, Sung Anjeon, Hyerim Kang, Seungyeon Ryu, Hyun‐Ji Park, Eunha Kim, Chul Hwan Bang, Ji Hyun Lee, Josephine M. Egan, Jung‐Woong Kim, Eun Kyung Lee, Wook Kim   +22 more
wiley   +1 more source

THE DEVELOPMENT OF ADENOVIRAL-INDUCED CORNEAL LESIONS IN CYCLOPHOSPHAMIDE TREATED RABBITS.

, 1980
THE DEVELOPMENT OF ADENOVIRAL-INDUCED CORNEAL LESIONS IN CYCLOPHOSPHAMIDE TREATED ...
HAROLD SIDNEY. SCHWARTZ (7993235)
core   +4 more sources

Hepatocyte CBX2 Safeguards Hepatic Lipid Homeostasis by Elevating Ca2+‐CaMKK2‐AMPK Signaling to Counter MASLD

Advanced Science, EarlyView.
In hepatocytes, CBX2 promotes H3K4me3 enrichment at the Orai1 promoter to enhance Orai1 transcriptional activation, thereby increasing intracellular Ca2+ levels. The elevated Ca2+ activates the CaMKK2‐AMPK signaling cascade, resulting in ACC phosphorylation and downstream metabolic regulation. This cascade suppresses de novo lipogenesis (Fasn, Acc, Scd‐
Xiang Wei, Li Lin, Xiuyun Wang, Hui Du, Menglong Zhang, Kechao Tang, Han Gao, Xinrui Xie, Jingya Gao, Xu Wang, Zhenglin Wang, Siwei Huang, Lei Zhang, Fang Gu, Gong‐Hong Wei, Yinliang Qi, Wei Chen, Yongsheng Chang, Huabing Zhang   +18 more
wiley   +1 more source

Prolonged effects of adenoviral vector priming on T-cell cytokine production in heterologous adenoviral vector/mRNA COVID-19 vaccination regimens

Scientific Reports
mRNA and adenoviral vector vaccine platforms were used for the primary series of COVID-19 vaccines in many countries. However, the distinct immunogenic properties on these platforms remain less understood.
Masanori Isogawa, Taishi Onodera, Akira Ainai, Ryutaro Kotaki, Takayuki Kanno, Shinji Saito, Minoru Tobiume, Kenzo Tokunaga, Megumi Hara, Yoshio Hirota, Tadaki Suzuki, Yoshimasa Takahashi, Tomomi Tsuru   +12 more
doaj   +1 more source