Results 141 to 150 of about 314,751 (339)

Partial Reprogramming in Senescent Schwann Cells Enhances Peripheral Nerve Regeneration via Restoration of Stress Granule Homeostasis

Advanced Science, EarlyView.
In this study, it is discovered that pathological accumulation of Runx2+ Schwann cell clusters​ during axonal regeneration is a key factor impairing nerve repair in aging. This pathology is associated with ​dysregulation of stress granule homeostasis.
Peilin Wang, Renyuan Wang, Yilin Huo, Ying Peng, Chuanliang Fu, Yi Hu, Zun Ren, Yersen Mulat, Hao Zhang, Dongsheng Jiang, Haodong Lin   +10 more
wiley   +1 more source

Single Fusion Pore Analysis via Single Cell Amperometry Uncovers Impaired Pore Expansion That Restricts Insulin Exocytosis in Human Type 2 Diabetes

Angewandte Chemie, EarlyView.
The final step in insulin exocytosis from pancreatic beta cells is the formation of the fusion pore. We combined single‐cell amperometry with microsensors and fluorescence microscopy to monitor insulin exocytosis from different perspectives. Our results reveal a link between impaired fusion pore function and diminished insulin secretion, highlighting ...
Amir Hatami, Nikhil R. Gandasi, Haiqiang Dou, Lakshmi Kothegala, Lena Eliasson, Andrew Ewing, Patrik Rorsman   +6 more
wiley   +2 more sources

Severe Adenovirus Pneumonia Masked by Influenza Virus in an 11-Year-Old Child: A Case Report

Infection and Drug Resistance
Yi Shi, Yifan Ren Department of Pediatrics, Shaoxing Keqiao Women and Children’s Hospital, Shaoxing, Zhejiang Province, People’s Republic of ChinaCorrespondence: Yi Shi, Email shiyi111002@163.comBackground: Adenovirus pneumonia progresses rapidly, with a
Shi Y, Ren Y
doaj  

Patchy Amphiphilic Dendrimers Bind Adenovirus and Control Its Host Interactions and in Vivo Distribution

, 2019
The surface of proteins is heterogeneous with sophisticated but precise hydrophobic and hydrophilic patches, which is essential for their diverse biological functions.
Andreozzi, P., Chakrabortty, S., D’Alicarnasso, M., Frank, L., Hammer, B., Kreppel, F., Krol, S., Kuan, S., Landfester, K., Li, L., Liu, W., Müllen, K., Pelliccia, M., Simon, J., Stellacci, F., Wagner, J., Weil, T., Wu, Y.   +17 more
core   +1 more source

Genetic Relatedness Studies with Adenovirus-associated Viruses [PDF]

, 1968
James A. Rose, M D Hoggan, Frank Koczot, Aaron J. Shatkin   +3 more
openalex   +1 more source

PDGFRα+DPP4+ Fibroblasts‐Macrophage Crosstalk Induces Orbital Fibrosis in Treatment‐Resistant Thyroid Eye Disease via the GAS6‐AXL Pathway

Advanced Science, EarlyView.
This study elucidates macrophage‐induced orbital fibrosis in TED via the GAS6‐AXL pathway, a treatment‐resistant disorder lacking non‐surgical therapies. Using a novel patient cell‐derived orthotopic animal model of orbital fibrosis for TED, we repurpose an existing fibrosis therapy, addressing the absence of stable models and offering a potential ...
Lu Cheng, Jinwei Cheng, Guiling Liang, Xiaorui Wang, Yanwen Ge, Jiapei Liu, Luwei Cai, Hui Ying, Fenfen Wang, Jing Hu, Yufan Wang, Philipp E. Scherer, Ben Zhou, Mengle Shao, Fang Zhang   +14 more
wiley   +1 more source

The Crosstalk Between CRL5 and APC/C E3 Ligases Regulates Metastasis and Chemosensitivity of Cancer Cells

Advanced Science, EarlyView.
This study uncovers a previously unknown crosstalk between two major ubiquitin ligases, CRL5 and APC/C. The authors identify APC11 as a binding partner of CUL5, showing that their interaction regulates neddylation, substrate stability, and mitotic progression.
Danrui Cui, Ruirui Qu, Tianqi Li, Linchen Wang, Xiaoyu Chen, Shengpeng Shao, Xue Liang, Jun Xu, Yi Sun, Xiufang Xiong, Yongchao Zhao   +10 more
wiley   +1 more source

Enhanced Deoxyribonucleic Acid Polymerase Activity in Human Embryonic Kidney Cultures Infected with Adenovirus 2 or 12 [PDF]

, 1968
Nada Ledinko
openalex   +1 more source

Arid1a Deficiency Drives Aristolochic Acid‐Induced Liver Tumorigenesis through Ctnnb1 Mutation and Defective Nucleotide Excision Repair

Advanced Science, EarlyView.
ARID1A is frequently mutated in both non‐malignant tissues and cancers, but its role in tumor development after exposure to genotoxic carcinogen remains unclear. It is found that aristolochic acid I accelerated liver tumorigenesis in ARID1A‐deficient context by impairing nucleotide excision repair and enhancing carcinogen bioactivation, revealing key ...
Lan Wang, Shi‐Hao Bai, Shu‐Jin Song, Xiao‐Li Zhang, Xue‐Ying Shang, Zhao‐Ning Lu, Xiao‐Fang Cui, Xin‐Le Zhu, Ze‐Guang Han   +8 more
wiley   +1 more source

Comparative analysis of the epidemiological characteristics of adenovirus, rotavirus A, and coinfection in children during 2014–2023 in Guangzhou, China

Virology Journal
Background Infection is the cause of diarrhoea, and rotaviruses and adenoviruses are important pathogens in children. Methods A retrospective study was conducted on 144,067 children with diarrhoea between 2014 and 2023 in China.
Yuqian Yan, Zhiwei Zeng, Huixin Gao, Shanshui Zeng, Siqin Duan, Jun Jiang, Xiaolan Ai, Lanlan Zeng, Shuwen Yao, Yan Long   +9 more
doaj   +1 more source