Results 31 to 40 of about 90,117 (254)

Loss of hepatic SMLR1 causes hepatosteatosis and protects against atherosclerosis due to decreased hepatic VLDL secretion

Hepatology, EarlyView., 2022
The role of SMLR1 in lipid metabolism (high fat + cholesterol diet in mice) Abstract Background and Aims The assembly and secretion of VLDL from the liver, a pathway that affects hepatic and plasma lipids, remains incompletely understood. We set out to identify players in the VLDL biogenesis pathway by identifying genes that are co‐expressed with the ...
Willemien van Zwol, Antoine Rimbert, Justina C. Wolters, Marieke Smit, Vincent W. Bloks, Niels J. Kloosterhuis, Nicolette C. A. Huijkman, Mirjam H. Koster, Umesh Tharehalli, Simon M. de Neck, Colin Bournez, Marceline M. Fuh, Jeroen Kuipers, Sujith Rajan, Alain de Bruin, Henry N. Ginsberg, Gerard J. P. van Westen, M. Mahmood Hussain, Ludger Scheja, Joerg Heeren, Philip Zimmerman, Bart van de Sluis, Jan Albert Kuivenhoven   +22 more
wiley   +1 more source

Eight Year Prospective Study of Adenoviruses Infections in Hospitalized Children. Comparison with Other Respiratory Viruses. [PDF]

PLoS ONE, 2015
Human adenovirus (HAdV) cause upper and lower respiratory tract infections. However, there are few large prospective studies focused on HAdVs acute infections requiring hospitalization.
Cristina Calvo, María Luz García-García, Rosa Sanchez-Dehesa, Cristina Román, Ana Tabares, Francisco Pozo, Inmaculada Casas   +6 more
doaj   +1 more source

Development and application of LAMP assays for the detection of enteric adenoviruses in feces

Microbiology Spectrum, 2022
Loop-mediated isothermal amplification (LAMP) is an alternative to PCR that is faster and requires fewer resources. Here, we describe two LAMP assays for the detection of human adenoviruses in the feces of children with acute intestinal infections.
Anna K. Shuryaeva, Tatyana V. Malova, Anna A. Tolokonceva, Sofia A. Karceka, Maria A. Gordukova, Ekaterina E. Davydova, German A. Shipulin   +6 more
doaj   +1 more source

Adeno‐associated virus serotype 2 capsid variants for improved liver‐directed gene therapy

Hepatology, EarlyView., 2022
Abstract Background and Aims Current liver‐directed gene therapies look for adeno‐associated virus (AAV) vectors with improved efficacy. With this background, capsid engineering is explored. Whereas shuffled capsid library screenings have resulted in potent liver targeting variants with one first vector in human clinical trials, modifying natural ...
Nadja Meumann, Marti Cabanes‐Creus, Moritz Ertelt, Renina Gale Navarro, Julie Lucifora, Qinggong Yuan, Karin Nien‐Huber, Ahmed Abdelrahman, Xuan‐Khang Vu, Liang Zhang, Ann‐Christin Franke, Christian Schmithals, Albrecht Piiper, Annabelle Vogt, Maria Gonzalez‐Carmona, Jochen T. Frueh, Evelyn Ullrich, Philip Meuleman, Steven R. Talbot, Margarete Odenthal, Michael Ott, Erhard Seifried, Clara T. Schoeder, Joachim Schwäble, Leszek Lisowski, Hildegard Büning   +25 more
wiley   +1 more source

Clinical and Epidemiological Features of New Polyethiologic Viral Infections

Эпидемиология и вакцинопрофилактика, 2018
The review article summarizes and systematizes scientific data on the pathogens of new respiratory infections discovered in the early XXI century – Human metapneumovirus (HMPV), Human bocavirus (HBoV), Human coronavirus (HCoV).
V. V. Shkarin, O. V. Kovalyshen, R. F. Chanysheva, A. V. Sergeeva, A. A. Rassokhin   +4 more
doaj   +1 more source

Infection of Mouse Liver by Human Adenovirus Type 5

Journal of General Virology, 1978
CBA mice, inoculated intravenously with large doses of adenovirus type 5, showed raised levels of serum aspartate aminotransferase (SAAT; EC 2.6.I.I) and died within a few days from histologically demonstrable hepatic necrosis. After inoculation of I LD50, virus was rapidly taken up by the tissues where infectivity then declined greatly.
S J, Duncan, F C, Gordon, D W, Gregory, J L, McPhie, R, Postlethwaite, R, White, H N, Willcox   +6 more
openaire   +2 more sources

Adenovirus facilitated infection of human cells with ecotropic retrovirus [PDF]

Gene Therapy, 1998
Retroviral infection is restricted by the expression of a viral receptor on the surface of the target cell. Retrovirus-mediated gene transfer is therefore not possible in cells that fail to express sufficient levels of the appropriate receptor, representing one major obstacle to the use of recombinant retroviruses in experimental and clinical ...
T H, Scott-Taylor, H F, Gallardo, B, Gänsbacher, M, Sadelain   +3 more
openaire   +2 more sources

AIF1+CSF1R+ MSCs, induced by TNF‐α, act to generate an inflammatory microenvironment and promote hepatocarcinogenesis

Hepatology, EarlyView., 2022
Mesenchymal stem cells subset, educated by TNF‐α, are involved to generate inflammatory microenvironment and promote hepatocarcinogenesis Abstract Background and Aims Increasing evidence suggests that mesenchymal stem cells (MSCs) home to injured local tissues and the tumor microenvironment in the liver.
Chen Zong, Yan Meng, Fei Ye, Xue Yang, Rong Li, Jinghua Jiang, Qiudong Zhao, Lu Gao, Zhipeng Han, Lixin Wei   +9 more
wiley   +1 more source

Abortive Infection of Human Cell Cultures by a Canine Adenovirus

Experimental Biology and Medicine, 1969
SummaryThe abortive infection of human amnion cells by infectious canine hepatitis virus (ICHV) was studied. Within 48 hr after inoculation, large quantities of complement fixing (CF) antigen were produced, although infectious virus yields were small.
W D, Gehle, K O, Smith
openaire   +2 more sources

Molecular characterization of human adenovirus infection in Thailand, 2009–2012 [PDF]

Virology Journal, 2013
AbstractBackgroundHuman adenovirus (HAdV) can cause a wide spectrum of human diseases worldwide.MethodsUsing PCR and sequence analysis, we investigated HAdV infection prevalence in the Thai population for four years from January 2009 to December 2012.
Punsinee Sriwanna, Thaweesak Chieochansin, Chanpim Vuthitanachot, Viboonsuk Vuthitanachot, Apiradee Theamboonlers, Yong Poovorawan   +5 more
openaire   +2 more sources