Results 31 to 40 of about 2,591 (127)

The cell adhesion molecule "CAR" and sialic acid on human erythrocytes influence adenovirus in vivo biodistribution.

PLoS Pathogens, 2009
Although it has been known for 50 years that adenoviruses (Ads) interact with erythrocytes ex vivo, the molecular and structural basis for this interaction, which has been serendipitously exploited for diagnostic tests, is unknown.
Elena Seiradake, Daniel Henaff, Harald Wodrich, Olivier Billet, Matthieu Perreau, Claire Hippert, Franck Mennechet, Guy Schoehn, Hugues Lortat-Jacob, Hanna Dreja, Sandy Ibanes, Vasiliki Kalatzis, Jennifer P Wang, Robert W Finberg, Stephen Cusack, Eric J Kremer   +15 more
doaj   +1 more source

Proteomic Remodeling in the Failing Left Ventricle Adapting to Dyssynchrony

PROTEOMICS – Clinical Applications, Volume 20, Issue 5, September 2026.
ABSTRACT Purpose In heart failure, dyssynchrony is associated with accelerated cardiac remodeling and a worse prognosis. Both restored with resynchronization. We have previously developed a mouse model of dyssynchrony and resynchronization and here assess changes in protein expression within that model.
Karin Ljung, Nitha Aima Muntu, Ulrika Reistam, Jonathan A. Kirk, Marcus Ståhlberg   +4 more
wiley   +1 more source

Deep Mutational Scanning for the Study and Engineering of Protein Assemblies

Chemistry–Methods, Volume 6, Issue 8, August 2026.
This review explores how deep mutational scanning (DMS) can be used to improve understanding and accelerate engineering of protein assemblies, from natural fibers to engineered nanocages. We discuss various types of protein assemblies and their characterization, provide an introduction to the DMS technique, and then highlight examples in which DMS has ...
Jenna B. Wolfanger, Shoili Banerjee, Carolyn E. Mills   +2 more
wiley   +1 more source

Ca2+‐Activated Cl− Channels: Do Bestrophins and TMEM16A Interact?

Acta Physiologica, Volume 242, Issue 6, June 2026.
ABSTRACT Aim Ca2+‐activated Cl– conductances are present in many cell types and are important for regulating membrane potential as well as other cellular functions. TMEM16A is widely accepted as the principal molecular basis for Ca2+‐activated Cl– conductances, but also members of the bestrophin family may be important for some Ca2+‐activated Cl ...
Christian Aalkjær, Vibeke Secher Dam, Holger Nilsson, Donna B. Boedtkjer, Vladimir Matchkov   +4 more
wiley   +1 more source

Protection of beagle dogs from mucosal challenge with canine oral papillomavirus by immunization with recombinant adenoviruses expressing codon-optimized early genes

Virology, 2005
Replication-deficient adenoviral (rAd5) vaccines containing codon-optimized E1, E2, E4, and E7 genes of canine oral papillomavirus (COPV) were tested singly or in combination to determine which vaccines could protect against mucosal challenge with COPV. In three studies, groups of 4-6 beagle dogs were immunized subcutaneously (s.c.) with 10(11) rAd5 at
Johnston, Kimberly B., Monteiro, Juanita M., Schultz, Loren D., Chen, Ling, Wang, Fubao, Ausensi, Virginia A., Dell, Elayne C., Santos, Elmer B., Moore, Richard A., Palker, Thomas J., Stanley, Margaret A., Jansen, Kathrin U.   +11 more
openaire   +2 more sources

Emerging Roles of Adenosine Metabolism in Astrocytes During Brain Injury

CNS Neuroscience &Therapeutics, Volume 32, Issue 5, May 2026.
Adenosine, as a key metabolic and neurotransmitter in the brain, has become an important therapeutic target for improving the efficacy of immunotherapy for stroke. However, gaps in knowledge about its metabolic pathways have become a key factor limiting its clinical translation.
Shu Zhu, Shanshan Zhong, Xiaoru Lin, Chuansheng Zhao, Yugang Li   +4 more
wiley   +1 more source

Advances in Gene Therapy for Xerostomia: Current Perspectives and Future Directions: A Narrative Review

Health Science Reports, Volume 9, Issue 5, May 2026.
ABSTRACT Background and Aims Xerostomia, or dry mouth, significantly impairs quality of life and oral health, particularly in patients subjected to radiation therapy or suffering from systemic disorders. This narrative review summarizes the current evidence on the efficacy and safety of gene therapy interventions for xerostomia, exploring innovative ...
Muhammad Usman Bilal, Sarah Alvi, Fatima Humayune, Hasan Mujtaba, Shahzad Ahmad, Shazia Iqbal, Muhammad Farooq Umer   +6 more
wiley   +1 more source

A Case of Sepsis Caused by ST80 Multidrug‐Resistant Enterococcus faecium With Concurrent Klebsiella pneumoniae Infection in a Dog

Veterinary Medicine and Science, Volume 12, Issue 3, May 2026.
An 8‐year‐old dog developed acute respiratory distress that progressed to sepsis and death. Multidrug‐resistant Enterococcus faecium ST80 was isolated from the liver and kidney, while Klebsiella pneumoniae was detected in the lung by PCR. Whole‐genome sequencing showed that the ST80 isolates were genetically identical, suggesting hematogenous spread ...
Hyung‐min Seo, Tae‐Min La, Ye‐ram Seo, Dong‐Yeop Lee, Hyun‐Jung Han, Ji‐Yeon Hyeon   +5 more
wiley   +1 more source

Ischaemic dermatopathy associated with multiple vaccinations in a miniature poodle

Veterinary Record Case Reports, Volume 14, Issue 2, May 2026.
Abstract A 10‐year‐old, spayed, female miniature poodle presented with hyperpigmented alopecia. Two months prior, it had received two polyvalent vaccines 2 weeks apart. Erythematous alopecia at the injection sites was initially observed. These rapidly expanded to the ventral neck and thoracic regions after further rabies vaccination.
Daekyung Kim, Sang‐Ik Oh, Jinho Park, Ji‐Seon Yoon   +3 more
wiley   +1 more source

Canine chronic idiopathic rhinitis: management and outcome – a single‐centre retrospective observational study

Journal of Small Animal Practice, Volume 67, Issue 5, Page 460-470, May 2026.
Objectives Canine chronic idiopathic rhinitis is a common cause of nasal disease in dogs but data reporting outcomes following treatment is lacking. The aim was to describe pre‐ and post‐referral management and outcomes of dogs diagnosed with canine chronic idiopathic rhinitis at a single referral centre.
P. M. N. Henry, R. Rizzo, Y. Tan, A. M. Boag, J. Del‐Pozo, G. A. Woods   +5 more
wiley   +1 more source