Results 41 to 50 of about 125,030 (157)

Proteomic Remodeling in the Failing Left Ventricle Adapting to Dyssynchrony

PROTEOMICS – Clinical Applications, Volume 20, Issue 5, September 2026.
ABSTRACT Purpose In heart failure, dyssynchrony is associated with accelerated cardiac remodeling and a worse prognosis. Both restored with resynchronization. We have previously developed a mouse model of dyssynchrony and resynchronization and here assess changes in protein expression within that model.
Karin Ljung, Nitha Aima Muntu, Ulrika Reistam, Jonathan A. Kirk, Marcus Ståhlberg   +4 more
wiley   +1 more source

Transmission dynamics and prospects for the elimination of canine rabies [PDF]

, 2009
Rabies has been eliminated from domestic dog populations in Western Europe and North America, but continues to kill many thousands of people throughout Africa and Asia every year.
Packer, C., Katie Hampson, Daniel T Haydon, Dobson, A., Magai Kaare, Dobson, Andy, Hampson, K., Packer, Craig, Dobson A., Hampson, Katie, Craig Packer, Packer C., Dushoff, Jonathan, Kaare, M., Dushoff J., Dushoff Jonathan, Haydon, Daniel T., Dobson Andy, Packer Craig, Dushoff, J., Rupprecht, C.E., Cleaveland, S., Jonathan Dushoff, Haydon D.T., Haydon Daniel T, Kaare, Magai, Haydon, D.T, Haydon, D.T., Kaare M., Hampson Katie, Cleaveland S., Cleaveland, Sarah, Sarah Cleaveland, Hampson K., Kaare Magai, Andy Dobson, Cleaveland Sarah   +36 more
core   +1 more source

Protection of beagle dogs from mucosal challenge with canine oral papillomavirus by immunization with recombinant adenoviruses expressing codon-optimized early genes

Virology, 2005
Replication-deficient adenoviral (rAd5) vaccines containing codon-optimized E1, E2, E4, and E7 genes of canine oral papillomavirus (COPV) were tested singly or in combination to determine which vaccines could protect against mucosal challenge with COPV. In three studies, groups of 4-6 beagle dogs were immunized subcutaneously (s.c.) with 10(11) rAd5 at
Johnston, Kimberly B., Monteiro, Juanita M., Schultz, Loren D., Chen, Ling, Wang, Fubao, Ausensi, Virginia A., Dell, Elayne C., Santos, Elmer B., Moore, Richard A., Palker, Thomas J., Stanley, Margaret A., Jansen, Kathrin U.   +11 more
openaire   +2 more sources

Table_1_Detection and Genetic Characterization of Canine Adenoviruses, Circoviruses, and Novel Cycloviruses From Wild Carnivores in Italy.docx

, 2022
Wild carnivores are known to play a role in the epidemiology of several canine viruses, including canine adenoviruses types 1 (CAdV-1) and 2 (CAdV-2), canine circovirus (CanineCV) and canine distemper virus (CDV).
Shadia Berjaoui (12330029), Gianvito Lanave (620178), Francesco Pellegrini (7870409), Linda A. Ndiana (12330017), Nicola Decaro (506185), Violetta Vasinioti (12330020), Giovanni Sgroi (502634), Maria Loredana Colaianni (12330026), Annamaria Pratelli (11034192), Antonio Camarda (331937), Costantina Desario (620177), Vito Martella (331223), Gabriella Elia (506187), Canio Buonavoglia (85490), Camillo Martino (12330023), Francesco Buono (12330032)   +15 more
core   +1 more source

Deep Mutational Scanning for the Study and Engineering of Protein Assemblies

Chemistry–Methods, Volume 6, Issue 8, August 2026.
This review explores how deep mutational scanning (DMS) can be used to improve understanding and accelerate engineering of protein assemblies, from natural fibers to engineered nanocages. We discuss various types of protein assemblies and their characterization, provide an introduction to the DMS technique, and then highlight examples in which DMS has ...
Jenna B. Wolfanger, Shoili Banerjee, Carolyn E. Mills   +2 more
wiley   +1 more source

Clinical outcome, imaging and histopathological findings of liver cirrhosis in dogs

Veterinary Record Case Reports, Volume 14, Issue 3, August 2026.
Abstract Cirrhosis is a severe and irreversible condition resulting from chronic liver injury, characterised by extensive fibrosis and regenerative nodules. This report describes three dogs with cirrhosis. The main clinical findings included ascites, reduced body condition score and inappetence. Anaemia, thrombocytopenia, hypoalbuminaemia, and elevated
Wanderson Feliciano Duarte da Silva, Roger Fernando Neves da Silva, Edson Moleta Colodel, Pedro Eduardo Brandini Nespóli, Valeria Regia Franco Sousa   +4 more
wiley   +1 more source

Ca2+‐Activated Cl− Channels: Do Bestrophins and TMEM16A Interact?

Acta Physiologica, Volume 242, Issue 6, June 2026.
ABSTRACT Aim Ca2+‐activated Cl– conductances are present in many cell types and are important for regulating membrane potential as well as other cellular functions. TMEM16A is widely accepted as the principal molecular basis for Ca2+‐activated Cl– conductances, but also members of the bestrophin family may be important for some Ca2+‐activated Cl ...
Christian Aalkjær, Vibeke Secher Dam, Holger Nilsson, Donna B. Boedtkjer, Vladimir Matchkov   +4 more
wiley   +1 more source

Emerging Roles of Adenosine Metabolism in Astrocytes During Brain Injury

CNS Neuroscience &Therapeutics, Volume 32, Issue 5, May 2026.
Adenosine, as a key metabolic and neurotransmitter in the brain, has become an important therapeutic target for improving the efficacy of immunotherapy for stroke. However, gaps in knowledge about its metabolic pathways have become a key factor limiting its clinical translation.
Shu Zhu, Shanshan Zhong, Xiaoru Lin, Chuansheng Zhao, Yugang Li   +4 more
wiley   +1 more source

Advances in Gene Therapy for Xerostomia: Current Perspectives and Future Directions: A Narrative Review

Health Science Reports, Volume 9, Issue 5, May 2026.
ABSTRACT Background and Aims Xerostomia, or dry mouth, significantly impairs quality of life and oral health, particularly in patients subjected to radiation therapy or suffering from systemic disorders. This narrative review summarizes the current evidence on the efficacy and safety of gene therapy interventions for xerostomia, exploring innovative ...
Muhammad Usman Bilal, Sarah Alvi, Fatima Humayune, Hasan Mujtaba, Shahzad Ahmad, Shazia Iqbal, Muhammad Farooq Umer   +6 more
wiley   +1 more source

The role of autophagy in neoplastic cell response to oncolytic viruses [PDF]

, 2009
Oncolytic conditionally replicating adenoviruses (CRAds) are viral mutants able to selectively replicate in tumour cells. CRAds are considered a promising platform for cancer therapy. dl922-947, bearing a mutation in E1A gene and AdΔΔ, carrying mutations
Botta, Ginevra
core   +1 more source