Results 51 to 60 of about 2,709 (155)

Adenovirus-based gene therapy approaches for hemophilia B [PDF]

, 2012
Gene therapy can be used to treat devastating inherited diseases, especially diseases and patients that are not suitable for a conventional cure. The blood clotting disorder hemophilia is one of the most extensively studied monogenetic diseases in gene ...
Zhang, Wenli
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Advances in Gene Therapy for Xerostomia: Current Perspectives and Future Directions: A Narrative Review

Health Science Reports, Volume 9, Issue 5, May 2026.
ABSTRACT Background and Aims Xerostomia, or dry mouth, significantly impairs quality of life and oral health, particularly in patients subjected to radiation therapy or suffering from systemic disorders. This narrative review summarizes the current evidence on the efficacy and safety of gene therapy interventions for xerostomia, exploring innovative ...
Muhammad Usman Bilal, Sarah Alvi, Fatima Humayune, Hasan Mujtaba, Shahzad Ahmad, Shazia Iqbal, Muhammad Farooq Umer   +6 more
wiley   +1 more source

Protection of beagle dogs from mucosal challenge with canine oral papillomavirus by immunization with recombinant adenoviruses expressing codon-optimized early genes

Virology, 2005
Replication-deficient adenoviral (rAd5) vaccines containing codon-optimized E1, E2, E4, and E7 genes of canine oral papillomavirus (COPV) were tested singly or in combination to determine which vaccines could protect against mucosal challenge with COPV. In three studies, groups of 4-6 beagle dogs were immunized subcutaneously (s.c.) with 10(11) rAd5 at
Johnston, Kimberly B., Monteiro, Juanita M., Schultz, Loren D., Chen, Ling, Wang, Fubao, Ausensi, Virginia A., Dell, Elayne C., Santos, Elmer B., Moore, Richard A., Palker, Thomas J., Stanley, Margaret A., Jansen, Kathrin U.   +11 more
openaire   +2 more sources

A Case of Sepsis Caused by ST80 Multidrug‐Resistant Enterococcus faecium With Concurrent Klebsiella pneumoniae Infection in a Dog

Veterinary Medicine and Science, Volume 12, Issue 3, May 2026.
An 8‐year‐old dog developed acute respiratory distress that progressed to sepsis and death. Multidrug‐resistant Enterococcus faecium ST80 was isolated from the liver and kidney, while Klebsiella pneumoniae was detected in the lung by PCR. Whole‐genome sequencing showed that the ST80 isolates were genetically identical, suggesting hematogenous spread ...
Hyung‐min Seo, Tae‐Min La, Ye‐ram Seo, Dong‐Yeop Lee, Hyun‐Jung Han, Ji‐Yeon Hyeon   +5 more
wiley   +1 more source

Ischaemic dermatopathy associated with multiple vaccinations in a miniature poodle

Veterinary Record Case Reports, Volume 14, Issue 2, May 2026.
Abstract A 10‐year‐old, spayed, female miniature poodle presented with hyperpigmented alopecia. Two months prior, it had received two polyvalent vaccines 2 weeks apart. Erythematous alopecia at the injection sites was initially observed. These rapidly expanded to the ventral neck and thoracic regions after further rabies vaccination.
Daekyung Kim, Sang‐Ik Oh, Jinho Park, Ji‐Seon Yoon   +3 more
wiley   +1 more source

Canine chronic idiopathic rhinitis: management and outcome – a single‐centre retrospective observational study

Journal of Small Animal Practice, Volume 67, Issue 5, Page 460-470, May 2026.
Objectives Canine chronic idiopathic rhinitis is a common cause of nasal disease in dogs but data reporting outcomes following treatment is lacking. The aim was to describe pre‐ and post‐referral management and outcomes of dogs diagnosed with canine chronic idiopathic rhinitis at a single referral centre.
P. M. N. Henry, R. Rizzo, Y. Tan, A. M. Boag, J. Del‐Pozo, G. A. Woods   +5 more
wiley   +1 more source

Connexin43 Deficiency Leads to Ventricular Arrhythmias by Reprogramming Proline Metabolism

Advanced Science, Volume 13, Issue 19, 2 April 2026.
The study demonstrated that connexin43 (Cx43) knockout caused arrhythmic phenotype and decreased proline content in vitro and in vivo. Mechanistically, Cx43 interacts with the amino acid transporter SNAT2 (sodium‐dependent neutral amino acid transporter), and its deficiency disrupts proline transport and metabolism.
Hangying Ying, Hangping Fan, Yunhe Wang, Ruhong Jiang, Dongsheng Cai, Hui Cheng, Hao Wang, Chenyang Jiang, Ping Liang   +8 more
wiley   +1 more source

Safeguarding a Flagship Species: Integrated Surveillance of Cross‐Species Pathogen Transmission in Giant Panda Ecosystems

Ecology and Evolution, Volume 16, Issue 3, March 2026.
Emerging infectious diseases increasingly threaten giant pandas and cohabiting species. This review analyzes pathogen transmission risks from domestic animals, wildlife, and vectors and proposes an integrated genomic surveillance framework for early warning and biodiversity conservation.
Xiaoli Sun, Yi Peng, Xiaoye Hao, Rong Dong, Zhilin Wang, Le Wang, Chengdong Wang, Xiangdong Wu, Zheng Chen, Wenbo Zhang, Xiaoli Tang   +10 more
wiley   +1 more source

Non‐Canonical Subiculum Circuit Organization and Function

Hippocampus, Volume 36, Issue 2, March 2026.
ABSTRACT The subiculum is highly interconnected with the hippocampus, sub‐regions of the thalamus, and the entorhinal and retrosplenial cortices. Together, these regions form a distributed network that plays critical roles in spatial cognition and learning and memory.
Pan Gao, Wenhao Cao, Douglas A. Nitz, Xiangmin Xu   +3 more
wiley   +1 more source

Genomic Variation in the Canine Adenoviruses [PDF]

, 1989
Considerable differences exist in the pathogenicity of wild-type and vaccine strains of canine adenovirus. An analysis of their genome structure was undertaken in orrder to investigate the molecular basis of their differing pathogenicities.
Cavanagh, Heather Margaret Ann
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