Results 111 to 120 of about 39,913 (259)

A functional SNP rs12718466 in APOA1 promoter modulates gene expression via interaction with SOX7. [PDF]

J Biol Chem
Aita Y, Takeuchi Y, Masuda Y, Mehrazad Saber Z, Karkoutly S, Tao D, Ye C, Mendsaikhan T, Saikawa R, Kondo Y, Murayama Y, Shikama A, Matsuzaka T, Shimano H, Kawakami Y, Yahagi N.   +15 more
europepmc   +1 more source

Precision Medicine in Neurodegeneration with Brain Iron Accumulation (NBIA) Disorders: An Update on Emerging Treatments

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Neurodegeneration with Brain Iron Accumulation (NBIA) is a heterogeneous group of heritable, mostly recessive, progressive neurodegenerative diseases characterized by iron deposition in the basal ganglia and brainstem. There are no solid global epidemiological data on prevalence and incidence of NBIA subtypes, but registry data and ...
Susanne A. Schneider, Divyani Garg, Vassilena Iankova, Thomas Klopstock   +3 more
wiley   +1 more source

Systematic review of point-of-need molecular diagnostics for rotavirus and enteric adenoviruses F40/F41. [PDF]

BMC Infect Dis
Top FK, Diagne CT, Touré CT, Gonfouli JM, Faye O, Dieye Y, Reboud J, Sow A, Cooper JM, Faye M.   +9 more
europepmc   +1 more source

Advances and challenges in experimental models for Epstein–Barr virus research

mLife, EarlyView.
Abstract Epstein–Barr virus (EBV), the first identified human oncovirus, is a ubiquitous γ‐herpesvirus etiologically linked to diverse malignancies, lymphoproliferative disorders, and autoimmune diseases. Experimental models are pivotal for unraveling the infection and pathogenesis mechanisms, life cycle regulation, as well as development and ...
Gulimire Wufuer, Jiabao Tang, Tingdong Li, Shengxiang Ge, Jun Zhang, Ningshao Xia   +5 more
wiley   +1 more source

Surveillance of the antiviral activity and mechanism of action of newly synthesized spirocyclic thio-pyrimidinones against human adenovirus type 40. [PDF]

Virol J
Manie EA, Ragab SS, Sweed AM, Nasser S, Allayeh AK, Elzayat EM.   +5 more
europepmc   +1 more source

Spheroids reveal hypoxia‑driven spatial restriction of adenoviral infection. [PDF]

Sci Rep
Büttner T, Wang X, Krishnacoumar B, Papadamakis A, Cicek S, Schild Y, Winning S, Littwitz-Salomon E, Ehrhardt A, Dittmer U, Bayer W, Fandrey J, Malyshkina A.   +12 more
europepmc   +1 more source

A Multiple‐Model‐Informed Drug‐Development Approach for Optimal Regimen Selection of an Oncolytic Virus in Combination With Pembrolizumab

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 572-582, March 2025.
ABSTRACT The antitumor efficacy of an intratumoral injection of a genetically engineered oncolytic vaccinia virus carrying human IL‐7 and murine IL‐12 genes (hIL‐7/mIL‐12‐VV) was demonstrated in CT26.WT‐bearing mice. In the CT26.WT‐bearing mouse model, the efficacy of the combination of hIL‐7/mIL‐12‐VV plus the anti‐programmed cell death protein (PD)‐1
Akihiro Yamada, Mary P. Choules, Frances A. Brightman, Shigeru Takeshita, Shinsuke Nakao, Nobuaki Amino, Takeshi Nakayama, Masato Takeuchi, Kanji Komatsu, Fernando Ortega, Hitesh Mistry, David Orrell, Christophe Chassagnole, Peter L. Bonate   +13 more
wiley   +1 more source

Desmoglein 2 (DSG2)-knockout human respiratory epithelial cell model to study species B adenovirus receptor usage. [PDF]

Virol Sin
Bahlmann N, Alshawabkeh M, Tsoukas R, Schröer K, Schellhorn S, Sieler M, Dittmar T, Ehrke-Schulz E, Ehrhardt A, Zhang W.   +9 more
europepmc   +1 more source

Cordycepin Alleviates Non Alcoholic Fatty Liver Disease Progression by Stabilizing GCH1 to Inhibit Ferroptosis

Phytotherapy Research, EarlyView.
COR stabilizes GCH1 and inhibits ferroptosis. ABSTRACT To investigate the effects and targets of cordycepin (COR) in alleviating non‐alcoholic fatty liver disease (NAFLD). High‐fat diet was used to induce NAFLD in mice, and after COR gavage administration, changes in liver function, glucose and lipid metabolism, and ferroptosis‐related signaling were ...
Chenyang Han, Jian Sheng, Hongyan Pei, Wenyan Li, Shasha Wu, Yi Yang, Chenxi Cao, Zhiling Tang   +7 more
wiley   +1 more source

Targeting the CD47–SIRPα phagocytic checkpoint in cancer: Biology, translational opportunities, and next‐generation therapeutic strategies

Smart Molecules, EarlyView.
The CD47–SIRPα axis has emerged as a critical innate immune checkpoint that suppresses macrophage‐mediated phagocytosis through a canonical “don't eat me” signal and enables tumor immune evasion. We comprehensively summarize the structural and biological features of CD47 and the molecular mechanisms underlying CD47‐mediated regulation of phagocytosis ...
Ruimei Zhou, Lingjie Jing, Jianping Zhang, Cheng Guo, Quanjun Yang   +4 more
wiley   +1 more source